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生殖与发育实验中联合暴露数据的阈值模型AI 解读

In risk assessment, thresholds are generally believed to exist for toxic reproductive and developmental agents. Therefore, dose combinations exist below the threshold where the response is not distinguishable from background and above the threshold where a dose-response trend results. Because data from combination experiments are more reflective of human exposure to environmental agents, threshold models that incorporate the effect of interactions among these agents are…

相关数据的响应面分析：非线性模型方法AI 解读

Statistical methods for fitting nonlinear functions to data generated by correlated response variates are discussed. Estimation of the model parameters is performed with an iterative two-stage scheme. The estimation procedure accommodates both within-unit and between-unit variability in fitting a response surface. Under regularity conditions the procedure yields asymptotically normal, strongly consistent estimators. If desired a patterned variance-covariance matrix can be…