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基于汇总数据、消除赢家诅咒的稳健孟德尔随机化AI 解读

In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR analyses, incorporating genetic variants as instrumental variables, are known for their robustness against reverse causation bias and unmeasured confounders. Nevertheless, classical MR analyses using summary data may still produce biased causal effect estimates due to the winner's curse and pleiotropy…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

破解孟德尔随机化中的赢家诅咒：再随机化逆方差加权估计量AI 解读

Developments in genome-wide association studies and the increasing availability of summary genetic association data have made the application of two-sample Mendelian Randomization (MR) with summary data increasingly popular. Conventional two-sample MR methods often employ the same sample for selecting relevant genetic variants and for constructing final causal estimates. Such a practice often leads to biased causal effect estimates due to the well-known “winner’s curse”…

高维检验中渐近独立的U统计量AI 解读

Many high-dimensional hypothesis tests aim to globally examine marginal or low-dimensional features of a high-dimensional joint distribution, such as testing of mean vectors, covariance matrices and regression coefficients. This paper constructs a family of U-statistics as unbiased estimators of the $\ell_{p}$-norms of those features. We show that under the null hypothesis, the U-statistics of different finite orders are asymptotically independent and normally distributed.…