Testing for Order-Restricted Hypotheses in Longitudinal Data
纵向数据中次序约束假设的检验
Summary In many biomedical studies, we are interested in comparing treatment effects with an inherent ordering. We propose a quadratic score test (QST) based on a quadratic inference function for detecting an order in treatment effects for correlated data. The quadratic inference function is similar to the negative of a log-likelihood, and it provides test statistics in the spirit of a χ2-test for testing nested hypotheses as well as for assessing the goodness of fit of…