The Ames Salmonella /Microsome Mutagenicity Assay: Issues of Inference and Validation
Ames 沙门氏菌／微粒体致突变试验：推断与验证
The importance of chemically induced mutation for human health is discussed briefly, and the biological basis for the primary in vitro assay for mutagenicity, the Ames Salmonella/microsome assay, is reviewed. A previous analysis for Ames test data, based on two mathematical models of the competing risks of mutation and toxicity, is shown to have inflated false-positive rates. A reason for this is the existence of local singularities in the Fisher information matrix. A new…