A Unified Semiparametric Framework for Quantitative Trait Loci Analyses, With Application to Spike Phenotypes
数量性状位点分析的统一半参数框架及尖峰型表型应用
This article proposes a general semiparametric model for multiple quantitative trait loci (QTL) analyses of complex phenotypes in backcross and intercross designs. The model provides tests about genetic hypotheses, such as additivity, dominance, and epistasis, that do not require specifying the form of the phenotypic distribution. This contrasts with previous approaches based on transformations to normality and generalized linear models, which require careful consideration…