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半参数核独立性检验及其突变特征应用AI 解读

Cancers arise owing to somatic mutations, and the characteristic combinations of somatic mutations form mutational signatures. Despite many mutational signatures being identified, mutational processes underlying a number of mutational signatures remain unknown, which hinders the identification of interventions that may reduce somatic mutation burdens and prevent the development of cancer. We demonstrate that the unknown cause of a mutational signature can be inferred by the…

Copula 结构的 M4 过程及其在高频金融数据中的应用AI 解读

Statistical applications of classical parametric max-stable processes are still sparse mostly due to lack of (1) efficiency of statistical estimation of many parameters in the processes, (2) flexibility of concurrently modeling asymptotic independence and asymptotic dependence among variables, and (3) capability of fitting real data directly. This paper studies a more flexible model, i.e. a class of copula structured M4 (multivariate maxima and moving maxima) processes, and…

通过嵌套高斯过程实现局部自适应贝叶斯非参数回归AI 解读

We propose a nested Gaussian process (nGP) as a locally adaptive prior for Bayesian nonparametric regression. Specified through a set of stochastic differential equations (SDEs), the nGP imposes a Gaussian process prior for the function’s mth-order derivative. The nesting comes in through including a local instantaneous mean function, which is drawn from another Gaussian process inducing adaptivity to locally varying smoothness. We discuss the support of the nGP prior in…

纵向研究中变化速率函数的半参数随机建模AI 解读

In longitudinal biomedical studies, there is often interest in the rate functions, which describe the functional rates of change of biomarker profiles. This paper proposes a semiparametric approach to model these functions as the realizations of stochastic processes defined by stochastic differential equations. These processes are dependent on the covariates of interest and vary around a specified parametric function. An efficient Markov chain Monte Carlo algorithm is…