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混合表达数据中细胞类型比例估计的统计推断AI 解读

There is a growing interest in cell-type-specific analysis from bulk samples with a mixture of different cell types. A critical first step in such analyses is the accurate estimation of cell-type proportions in a bulk sample. Although many methods have been proposed recently, quantifying the uncertainties associated with the estimated cell-type proportions has not been well studied. Lack of consideration of these uncertainties can lead to missed or false findings in…

高维多元点过程的潜在网络结构学习AI 解读

Learning the latent network structure from large scale multivariate point process data is an important task in a wide range of scientific and business applications. For instance, we might wish to estimate the neuronal functional connectivity network based on spiking times recorded from a collection of neurons. To characterize the complex processes underlying the observed data, we propose a new and flexible class of nonstationary Hawkes processes that allow both excitatory…

利用具有活跃与非活跃状态的聚集点过程学习人类活动模式AI 解读

Modeling event patterns is a central task in a wide range of disciplines. In applications such as studying human activity patterns, events often arrive clustered with sporadic and long periods of inactivity. Such heterogeneity in event patterns poses challenges for existing point process models. In this article, we propose a new class of clustered point processes that alternate between active and inactive states. The proposed model is flexible, highly interpretable, and can…