Finding Words with Unexpected Frequencies in Deoxyribonucleic Acid Sequences
识别DNA序列中频率异常的词串
SUMMARY Considering a Markov chain model for deoxyribonucleic acid sequences, this paper proposes two asymptotically normal statistics to test whether the frequency of a given word is concordant with the first-order Markov chain model or not. The problem is to choose estimates μ^(W) of the expectation of the frequency Mw of a word W in the observed sequence such that the asymptotic variance of MW−μ^(W) is easily computable. The first estimator is derived from the frequency…