SMART-MC: Characterizing the Dynamics of Multiple Sclerosis Therapy Transitions Using a Covariate-Based Markov Model
SMART-MC：基于协变量的多发性硬化治疗转换模型
Treatment switching is a common occurrence in the management of Multiple Sclerosis (MS), where patients transition across various disease-modifying therapies (DMTs) due to heterogeneous treatment responses, differences in disease progression, patient characteristics, and therapy-associated adverse effects. To investigate how patient-level covariates influence the likelihood of treatment transitions among DMTs, we adopt a Markovian framework, Sparse Matrix Estimation with…