论文检索

化学图谱中核小体定位信号的局部卷积簇模型AI 解读

Nucleosome is the fundamental packing unit of DNA in eukaryotic cells, and its positioning plays a critical role in regulation of gene expression and chromosome functions. Using a recently developed chemical mapping method, nucleosomes can be potentially mapped with an unprecedented single-base-pair resolution. Existence of overlapping nucleosomes due to cell mixture or cell dynamics, however, causes convolution of nucleosome positioning signals. In this paper, we introduce…

Rasch及相关指数响应模型的半参数估计与潜类别分析AI 解读

The Rasch model for item analysis is an important member of the class of exponential response models in which the number of nuisance parameters increases with the number of subjects, leading to the failure of the usual likelihood methodology. Both conditional-likelihood methods and mixture-model techniques have been used to circumvent these problems. In this article, we show that these seemingly unrelated analyses are in fact closely linked to each other, despite dramatic…

摘要暂缺

条件得分函数的若干最优性结果AI 解读

The conditional score function has previously been shown to generate the optimal estimating equation for a parameter of interest when the conditioning statistic is complete and sufficient for the nuisance parameters (Godambe, 1976). The present paper generalizes these results to partial likelihood factorizations and then examines the nature of the problem when the appropriate conditioning statistics depend on the parameter of interest. In this case, globally optimal…

条件得分函数的若干最优性结果AI 解读

The conditional score function has previously been shown to generate the optimal estimating equation for a parameter of interest when the conditioning statistic is complete and sufficient for the nuisance parameters (Godambe, 1976). The present paper generalizes these results to partial likelihood factorizations and then examines the nature of the problem when the appropriate conditioning statistics depend on the parameter of interest. In this case, globally optimal…