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Proximal survival analysis to handle dependent right censoring

处理依赖性右删失的近端生存分析

Abstract Many epidemiological and clinical studies aim to analyse a time-to-event endpoint. A common complication is right censoring. In some cases, right censoring occurs when subjects are still surviving after the study terminates or move out of the study area. In such cases, right censoring is typically treated as independent or noninformative. This assumption can be further relaxed to conditional independent censoring by leveraging possibly time-varying covariate…

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Doubly robust estimation under covariate-induced dependent left truncation

协变量诱导的依赖左截断下的双重稳健估计

Summary In prevalent cohort studies with follow-up, the time-to-event outcome is subject to left truncation leading to selection bias. For estimation of the distribution of the time to event, conventional methods adjusting for left truncation tend to rely on the quasi-independence assumption that the truncation time and the event time are independent on the observed region. This assumption is violated when there is dependence between the truncation time and the event time,…

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Proximal causal inference for complex longitudinal studies

复杂纵向研究中的近端因果推断

Abstract A standard assumption for causal inference about the joint effects of time-varying treatment is that one has measured sufficient covariates to ensure that within covariate strata, subjects are exchangeable across observed treatment values, also known as ‘sequential randomization assumption (SRA)’. SRA is often criticized as it requires one to accurately measure all confounders. Realistically, measured covariates can rarely capture all confounders with certainty.…

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