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Financially adaptive clinical trials via option pricing analysis

通过期权定价分析设计财务自适应临床试验

The regulatory approval process for new therapies involves costly clinical trials that can span multiple years. When valuing a candidate therapy from a financial perspective, industry sponsors may terminate a program early if clinical evidence suggests market prospects are not as favorable as originally forecasted. Intuition suggests that clinical trials that can be modified as new data are observed, i.e., adaptive trials, are more valuable than trials without this…

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Econometric measures of connectedness and systemic risk in the finance and insurance sectors

We propose several econometric measures of connectedness based on principal-components analysis and Granger-causality networks, and apply them to the monthly returns of hedge funds, banks, broker/dealers, and insurance companies. We find that all four sectors have become highly interrelated over the past decade, likely increasing the level of systemic risk in the finance and insurance industries through a complex and time-varying network of relationships. These measures can…

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Foundations of Technical Analysis: Computational Algorithms, Statistical Inference, and Empirical Implementation

Technical analysis, also known as “charting,” has been a part of financial practice for many decades, but this discipline has not received the same level of academic scrutiny and acceptance as more traditional approaches such as fundamental analysis. One of the main obstacles is the highly subjective nature of technical analysis—the presence of geometric shapes in historical price charts is often in the eyes of the beholder. In this paper, we propose a systematic and…

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Nonparametric Estimation of State‐Price Densities Implicit in Financial Asset Prices

ABSTRACT Implicit in the prices of traded financial assets are Arrow–Debreu prices or, with continuous states, the state‐price density (SPD). We construct a nonparametric estimator for the SPD implicit in option prices and we derive its asymptotic sampling theory. This estimator provides an arbitrage‐free method of pricing new, complex, or illiquid securities while capturing those features of the data that are most relevant from an asset‐pricing perspective, for example,…

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Long-Term Memory in Stock Market Prices

股票市场价格的长期记忆

A test for long-term memory that is robust to short-range dependence is developed. It is a modification of the R/S statistic, and the relevant asymptotic sampling theory is derived via functional central limit theory. Contrary to previous findings, when applied to daily and monthly stock returns indexes over several time periods this test yields no evidence of long-range dependence once short-range dependence is accounted for. Monte Carlo experiments show that the modified…

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Maximum Likelihood Estimation of Generalized Itô Processes with Discretely Sampled Data

离散观测下广义 Itô 过程的最大似然估计

This paper considers the parametric estimation problem for continuous-time stochastic processes described by first-order nonlinear stochastic differential equations of the generalized Itô type (containing both jump and diffusion components). We derive a particular functional partial differential equation which characterizes the exact likelihood function of a discretely sampled Itô process. In addition, we show by a simple counterexample that the common approach of estimating…

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