Descartes’ rule of signs and the identifiability of population demographic models from genomic variation data
笛卡尔符号法则与基因组变异数据中种群历史模型的可识别性
The sample frequency spectrum (SFS) is a widely-used summary statistic of genomic variation in a sample of homologous DNA sequences. It provides a highly efficient dimensional reduction of large-scale population genomic data and its mathematical dependence on the underlying population demography is well understood, thus enabling the development of efficient inference algorithms. However, it has been recently shown that very different population demographies can actually…