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基于模板的碱基对分辨率全基因组测序分析模型AI 解读

We consider the problem of estimating the genome-wide distribution of nucleosome positions from paired-end sequencing data. We develop a modeling approach based on nonparametric templates to control for the variability along the sequence of read counts associated with nucleosomal DNA due to enzymatic digestion and other sample preparation steps, and we develop a calibrated Bayesian method to detect local concentrations of nucleosome positions. We also introduce a set of…

利用间接测量估计网络中的潜在过程AI 解读

In a communication network, point-to-point traffic volumes over time are critical for designing protocols that route information efficiently and for maintaining security, whether at the scale of an Internet service provider or within a corporation. While technically feasible, the direct measurement of point-to-point traffic imposes a heavy burden on network performance and is typically not implemented. Instead, indirect aggregate traffic volumes are routinely collected. We…