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最优动态治疗方案的高维A-learningAI 解读

Precision medicine is a medical paradigm that focuses on finding the most effective treatment decision based on individual patient information. For many complex diseases, such as cancer, treatment decisions need to be tailored over time according to patients' responses to previous treatments. Such an adaptive strategy is referred as a dynamic treatment regime. A major challenge in deriving an optimal dynamic treatment regime arises when an extraordinary large number of…

用于亚组识别与样本量计算的变平面分析AI 解读

Ailin Fana, Rui Songa & Wenbin Lua*a Department of Statistics, North Carolina State University, Raleigh, NCCONTACT Wenbin Lu lu@stat.ncsu.edu Department of Statistics, North Carolina State University, Raleigh, NC 27695ABSTRACTWe propose a systematic method for testing and identifying a subgroup with an enhanced treatment effect. We adopts a change-plane technique to first test the existence of a subgroup, and then identify the subgroup if the null hypothesis on nonexistence…