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IFAA：微生物组绝对丰度的稳健关联识别与推断AI 解读

The target of inference in microbiome analyses is usually relative abundance (RA) because RA in a sample (e.g., stool) can be considered as an approximation of RA in an entire ecosystem (e.g., gut). However, inference on RA suffers from the fact that RA are calculated by dividing absolute abundances (AAs) over the common denominator (CD), the summation of all AA (i.e., library size). Because of that, perturbation in one taxon will result in a change in the CD and thus cause…

结构性无应答下多层调查数据的域级协方差分析AI 解读

Health care quality surveys in the United States are administered to individual respondents (i.e., hospital patients, health plan members) to evaluate the performance of health care organizations (i.e., hospitals, health plans), which thus constitute estimation domains. For better understanding and more parsimonious reporting of dimensions of quality, we analyze relationships among quality measures at the domain level. Rather than specifying a full parametric model for the…