Optimum designs for two treatments with unequal variances in the presence of covariates
协变量存在时两种异方差处理的最优设计
Optimum designs are described for two treatments with different variances when covariates are included in the model. The designs, a generalization of Neyman allocation, are required in personalized medicine to model the effect of covariates on the choice of treatment. The use of the designs in clinical trials is indicated. D-optimality of the designs is established using results from Kiefer’s general equivalence theorem. The results are obtained with the use of surprisingly…