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We study difference-in-differences designs in which all units are initially untreated and later receive heterogeneous, strictly positive treatment doses. When quasi-untreated units receive doses close to zero, a difference-in-difference estimand using those units as the control group identifies a weighted average treatment effect per unit of treatment, under a parallel-trends assumption. We develop a nonparametric estimator and bias-corrected confidence intervals for this…

Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous…

高维线性模型中基于汇总统计量的遗传力估计的一致性AI 解读

In Genome-Wide Association Studies (GWAS), heritability is defined as the fraction of variance of an outcome explained by a large number of genetic predictors in a high-dimensional polygenic linear model. This work studies the asymptotic properties of the most common estimator of heritability from summary statistics called linkage disequilibrium score (LDSC) regression, together with a simpler and closely related estimator called GWAS heritability (GWASH). These estimators…

时空干扰下用于实验的聚类切换设计AI 解读

We consider experimentation in the presence of non-stationarity, inter-unit (spatial) interference, and carry-over effects (temporal interference), where we wish to estimate the global average treatment effect (GATE), the difference between average outcomes having exposed all units at all times to treatment or to control. We suppose spatial interference is described by a graph, where a unit's outcome depends on its neighborhood's treatments, and that temporal interference is…

We consider the joint estimation of change-point locations and the sparsity pattern of the variance-covariance matrix, which is assumed to evolve in a piecewise constant manner. By applying Group Fused LASSO and LASSO penalties to the squared Frobenius norm, we estimate both the covariance structure and the change points. Adaptive weights are incorporated into the penalty terms to enhance change-point detection and covariance estimation accuracy. We establish the conditions…

This article develops an identification framework for heterogeneous policy effects when individual-level data are available only in the treated jurisdiction. The framework combines outcome changes from repeated cross-sections within that jurisdiction with a population-average effect identified from aggregate panel data. Under conditional relative parallel trends and overlap, this information identifies subgroup effects standardized to the treated jurisdiction's overall…

多元Lévy自适应B样条回归AI 解读

We propose Multivariate Lévy Adaptive B-Spline Regression (MLABS), a Bayesian nonparametric regression model designed to capture nonlinear effects, interactions, and locally varying features of multivariate functions. MLABS represents the regression function as a random sum of low-order tensor-product B-spline basis functions under a finite Lévy random measure prior. The resulting representation adapts to the complexity and local structure of the regression function while…

Schmelzer and Hastie prove that Markowitz's Critical Line Algorithm and the LASSO path trace the same curve. This companion note checks that result numerically with a stock LASSO solver, \texttt{lars\_path} from \texttt{scikit-learn}, and no portfolio software. It covers long--short portfolios under a leverage cap, fixed leverage with varying risk appetite, and the classical long-only, fully invested frontier. Every corner the path returns meets its own optimality conditions…

Understanding associations between paired high-dimensional longitudinal datasets is a fundamental yet challenging problem arising across scientific domains, including longitudinal multi-omic studies. The difficulty stems from the complex, time-varying cross-covariance structure coupled with high dimensionality, which complicates both model formulation and statistical estimation for association discovery. To address these challenges, we propose a new framework called…

从图套索到原子范数：高维模式恢复AI 解读

We study high-dimensional precision-matrix estimation with polyhedral atomic-norm penalties on the off-diagonal entries. This framework covers the graphical lasso, $\ell_\infty$-type penalties, SLOPE/OWL penalties, and penalties motivated by colored graphical models. We define the target pattern through the subdifferential face of the dual ball and derive sufficient conditions for exact pattern recovery from the sample covariance matrix. Our analysis introduces two geometric…

结合 model-X knockoffs 与 p 值的高维线性模型 FDR 控制AI 解读

We propose a novel multiple testing methodology for controlling the false discovery rate (FDR) in high-dimensional linear models that integrates model-X knockoff techniques with debiased penalized regression estimators. At the foundation of our methodology, we construct and study two sets of naturally paired high-dimensional test statistics and the associated $p$-values for evaluating the same null hypotheses. The first set is shown to be asymptotically mutually independent,…

组间不平衡下的风险异质性稳健推断AI 解读

Population-level heterogeneity is ubiquitous in biomedical data, where differences across demographic or clinical subgroups can substantially alter risk patterns. For example, in intensive care unit (ICU) studies, the mortality risk associated with specific admission diagnoses can vary across ethnic groups. Existing approaches for detecting risk heterogeneity are often sensitive to baseline model misspecification and regularization bias, both of which commonly arise in…

利用信息增强自适应 Lasso 选择平稳与非平稳自回归模型AI 解读

We propose a novel approach to elicit the weight of a potentially non-stationary regressor in the consistent and oracle-efficient estimation of autoregressive models using the adaptive Lasso. The enhanced weight builds on a statistic that exploits distinct orders in probability of the OLS estimator in time series regressions when the degree of integration differs. We provide theoretical results on the benefit of our approach for detecting stationarity when a tuning criterion…

We show that the activation knot of a potentially non-stationary regressor on the adaptive Lasso solution path in autoregressions can be leveraged for selection-free inference about a unit root. The resulting test has asymptotic power against local alternatives in $1/T$ neighbourhoods, unlike post-selection inference methods based on consistent model selection. Exploiting the information enrichment principle devised by Reinschlüssel and Arnold (arXiv:2402.16580 [stat.ME]) to…

自适应 Lasso 解路径单位根检验的自助法改进AI 解读

We propose sieve wild bootstrap analogues to the adaptive Lasso solution path unit root tests of Arnold and Reinschlüssel (2024) arXiv:2404.06205 to improve finite sample properties and extend their applicability to a generalised framework, allowing for non-stationary volatility. Numerical evidence shows the bootstrap to improve the tests' precision for error processes that promote spurious rejections of the unit root null, depending on the detrending procedure. The…

PICPIs：预测区间条件预测区间AI 解读

A classical question in statistics is which observable quantities to condition on when drawing inferences about unobservable targets. For conformal prediction in nonparametric uncertainty quantification, standard marginal validity offers limited resolution at the prediction values on which decisions are based, and fully conditional guarantees with respect to the covariates are provably unattainable. We address this gap by introducing a prediction-based conditioning framework…

Motivation: Mediation analysis is an important tool for elucidating causal mechanisms in biomedical research and has recently gained increasing attention in microbiome studies. Motivated by a microbiome study of acute myeloid leukemia (AML) patients, we investigate whether the effect of induction chemotherapy intensity on infection status is mediated through gut microbial taxa. This problem poses substantial methodological challenges due to the high dimensionality, zero…

度量统计视角下的随机集AI 解读

Since the seminal work by Beresteanu and Molinari(2008), the random set theory and related inference methods have been widely applied in partially identified econometric models. Meanwhile, there is an emerging field in statistics for studying random objects in metric spaces, called metric statistics. This paper clarifies a relationship between two fundamental concepts in these literatures, the Aumann and Fréchet means, and presents some applications of metric statistics to…

Bayesian additive regression trees (BART) is a popular Bayesian ensemble model used in regression and classification analysis. Under this modeling framework, the regression function is approximated by an ensemble of decision trees, interpreted as weak learners. In this work, we propose a generalization of the BART model that has two main features: first, it automatically selects the number of decision trees using the given data; second, the model allows clusters of…

观测因果推断中不完全识别下的相对偏差AI 解读

To conduct causal inference in observational settings, researchers must rely on certain identifying assumptions. In practice, these assumptions are unlikely to hold exactly. This paper considers the bias of selection-on-observables, instrumental variables, and proximal inference estimates under violations of their identifying assumptions. We develop bias expressions for IV and proximal inference that show how violations of their respective assumptions are amplified by any…

经验贝叶斯方法的稳健化AI 解读

Two strategies are explored for robustifying classical denoising procedures for the Gaussian sequence model. First, the Hodges and Lehmann (1952) restricted Bayes approach is used to reduce sensitivity to the specification of the initial prior distribution. Second, alternatives to the Gaussian noise assumption are explored. In both cases proposals of Huber (1964) and Mallows (1978) play a crucial role.

估计纵向因果剂量反应关系的贝叶斯框架AI 解读

Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal causal dose-response relationships under continuous exposures. We propose a scalable, nonparametric Bayesian framework for estimating marginal longitudinal causal dose-response functions with repeated outcome measurements. Our approach…

The conditional average treatment effect (CATE) is frequently estimated in clinical studies to refute a homogeneous treatment effect hypothesis. Under this regime, all patients making up the population experience identical benefit from a given treatment relative to a comparator. Uncovering heterogeneous treatment effects through inference about the CATE, however, requires that covariates truly modifying the treatment effect be reliably collected at baseline. CATE-based…

Mendelian randomization (MR) infers causal effects of exposures on outcomes using genetic variants as instrumental variables, but existing methods remain vulnerable to bias and loss of power when instruments are invalid. We hypothesize that closely related outcome traits share a large overlap in their valid instruments for a given exposure, so that borrowing instruments across such traits can yield more robust MR inference. To operationalize this, we introduce a novel…