每日简报

用匹配自适应随机化推断重新评估激素替代疗法对心脏病的影响AI 解读

Matching is an appealing way to design observational studies because it mimics the data structure produced by stratified randomized trials, pairing treated individuals with similar controls. After matching, inference is often conducted using methods tailored for stratified randomized trials in which treatments are permuted within matched pairs. However, in observational studies, matched pairs are not predetermined before treatment; instead, they are constructed based on…

通过潜在空间分布匹配进行半监督生成学习AI 解读

We introduce Latent Space Distribution Matching (LSDM), a novel framework for semi-supervised generative modeling of conditional distributions. LSDM operates in two stages: (i) learning a low-dimensional latent space from both paired and unpaired data, and (ii) performing joint distribution matching in this space via the 1-Wasserstein distance, using only paired data. This two-step approach minimizes an upper bound on the 1-Wasserstein distance between joint distributions,…

依赖结构下的聚类后推断AI 解读

Recent work by Gao et al. (2024) has laid the foundations for post-clustering inference, establishing a theoretical framework allowing to test for differences between means of estimated clusters. Additionally, they studied the estimation of unknown parameters while controlling the selective type I error. However, their theory was developed for independent observations identically distributed as p-dimensional Gaussian variables, where the parameter estimation could only be…

MOSAiC：多站点压缩风险函数的一次性聚合AI 解读

Multi-center research has strengthened the generalizability and reproducibility of scientific findings, yet multi-site inference in modern distributed research networks remains constrained by privacy regulations, heterogeneous site characteristics, and the logistical burden of human-in-the-loop, multi-round communication. In this work, we distill these operational constraints into four mathematical requirements for practical distributed inference and introduce MOSAiC, a…

基于偏 Gini 协方差的重尾误差高维线性模型稳健推断AI 解读

This paper introduces a novel robust high-dimensional inference framework based on partial Gini covariance. We specifically address the practically important problem of quantifying how changes in features affect the conditional mean in high-dimensional linear regression when the random noises are heavy-tailed and possibly asymmetric. Conventional high-dimensional regression inference methods suffer from inaccurate type I errors and reduced power in heavy-tailed contexts.…

跨疾病临床治疗指标的关联：基于 SEER-Medicare 的深度神经网络分析AI 解读

In outcomes research, clinical treatment measures are routinely analyzed. Most existing studies focus on individual diseases, and increasing recent evidence suggests that clinical treatment measures of different diseases can be “correlated” (or interconnected). Existing studies on such interconnections are usually limited to a small number of diseases. In this study, for U.S. older patients with common cancers, we complement the existing literature and conduct a pan-disease…

针对协变量完全缺失的增广迁移回归学习AI 解读

Abstract Large-scale population-level datasets, such as the UK Biobank and the All of Us Research Program, often lack covariates needed for a specific analysis, such as genetic or lifestyle measures, while related studies measure them. This creates a cross-population missing-data problem in which covariates are completely unobserved in the target population, rather than partially missing within one dataset. We propose an augmented transfer regression learning method for this…

高维异质中介分析的检验功效增强AI 解读

Mediation models are widely used in many scientific areas to understand how an exposure variable impacts an outcome variable through an intermediate variable. In this article, we develop powerful inferential methods to analyze mediation effects in high-dimensional contexts with intercorrelated potential mediators in models with linear and generalized linear outcomes. We draw attention to heterogeneous mediation, and show that existing testing approaches based on the total…

利用星际边界探测器数据分离带状与全球分布通量的统计方法AI 解读

NASA’s Interstellar Boundary Explorer (IBEX) satellite collects data on energetic neutral atoms (ENAs) that can provide insight into the heliosphere boundary between our solar system and interstellar space. Using these data, scientists can construct maps of the ENA intensities (often, expressed in terms of flux) observed in all directions. The ENA flux observed in these maps is believed to come from at least two distinct sources: one source which manifests as a ribbon of…

平均处理效应局部化：合成控制中的投影方法AI 解读

Many real-world policies and business interventions require assessing short-term effects to inform timely decisions, even though most causal inference methods focus on long-term average treatment effects. In this article, we introduce average treatment effect localization (ATEL), which captures localized, short-term policy impacts in panel data settings with a single treated unit and provides early indicators of policy impact. To accommodate both time-varying and nonlinear…

通过模型平均实现多层网络迁移学习的框架AI 解读

Link prediction in multilayer networks is a key challenge in applications such as recommendation systems and protein-protein interaction prediction. While many techniques have been developed, most rely on assumptions about shared structures and require access to raw auxiliary data, limiting their practicality. To address these issues, we propose a novel transfer learning framework for multilayer networks using a bi-level model averaging method. A $K$-fold cross-validation…

预印本版本摘要 · 查看来源

协变量自适应随机实验中混合效应模型的统计推断AI 解读

Recent clinical studies increasingly involve a long factor with many levels, e.g., investigation sites, resulting in a large number of strata that must be accounted for either through design or subsequent analysis. This complication has prompted concerns from the U.S. Food and Drug Administration (FDA, 2023) regarding the adequacy of standard statistical methods, whose performance may deteriorate, and their properties become unclear when the number of strata is relatively…

面向重尾数据的高维切片逆 Kendall 秩相关估计AI 解读

Sufficient dimension reduction is an important branch of statistical learning, which performs an optimal projection of covariates under a supervised learning framework. Most of the existing sufficient dimension reduction algorithms require strict restrictions on the distribution of models, making them sensitive to heavy-tailed predictors and outliers. In this article, we propose a novel method called Sliced Inverse Kendall’s tau Estimation (SIKE) designed for analyzing…

集体家庭消费中的规模经济AI 解读

ABSTRACT Browning et al. (2013) model collective‐household economies of scale in goods consumption by having each good be partly shared, instead of each good being public or private. We modify their model to achieve simple point identification and estimation of the economies of scale of consumption of each good, and we provide a new index of household level economies of scale. Our model has a linear form, permits households of varying composition, including children, and…

用广义加性密度比模型处理正例与未标记数据AI 解读

Abstract This paper focuses on learning from positive and unlabelled (PU) data, where only some positives are labelled and the rest are mixed with negatives. Classical exponential tilting models guarantee identifiability by imposing a linear structure, but they can be severely misspecified when the true relationships are nonlinear. We propose a generalized additive density-ratio framework that retains identifiability while allowing nonlinear and feature-specific effects. The…

离散空间随机场的有向图模型混合AI 解读

Current approaches for modeling discrete-valued outcomes associated with spatially-dependent areal units incur computational and theoretical challenges, especially in the Bayesian setting when full posterior inference is desired. As an alternative, we propose a novel statistical modeling framework for this data setting, namely a mixture of directed graphical models (MDGMs). The components of the mixture, directed graphical models, can be represented by directed acyclic…

预印本版本摘要 · 查看来源

结果选择下用于目标因果推断的协作表征AI 解读

Estimating causal effects with missing outcomes requires learning outcome, exposure, and selection models. Flexible propensity learners can predict treatment or missingness well while worsening target estimation by emphasizing instruments, weak-overlap regions, or variation unrelated to outcome-regression bias. We propose a collaborative representation-based targeted learning method for recovered average treatment effects under outcome selection. The method learns…

基于最优传输的稳定因果估计AI 解读

In observational studies, the overlap assumption, also called positivity, is frequently strained in practice. Limited overlap destabilizes widely used estimators such as inverse propensity weighting (IPW), whose variance depends on density ratios that explode as propensity scores approach zero or one. To address this challenge, we propose the Stable Transport Estimator (STE), an optimal transport-based approach for estimating average causal effects when overlap holds but…

稀疏多面体正则化中Hoffman常数的显式界AI 解读

Hoffman constants quantify the distance to the solution set of a polyhedral system in terms of its residual; they control error bounds, geometric conditioning, the convergence rate of first-order iterative algorithms, and the stability of regression estimators to target perturbations. Despite their importance, explicit values of Hoffman constants are rarely available due to their computational complexity. In this paper, we derive explicit bounds on the Hoffman constant for a…

用循环神经网络预测自回归非因果过程AI 解读

This paper examines the use of recurrent neural networks and their extensions for forecasting autoregressive causal-noncausal processes, characterized by local explosive patterns such as bubbles and spikes. We study the recurrent neural networks (RNN), long short-term memory networks (LSTM), gated recurrent unit (GRU), bidirectional LSTM, and also a simple feed-forward network (FNN) to reveal the difficulty of forecasting extreme values depending on the type of network and…

带自回归误差的线性回归在线变点检测：流式变分贝叶斯方法AI 解读

Large-scale streaming time-series regression requires methods that can detect structural changes while accounting for serially correlated errors and quantifying uncertainty about the current regime. We propose a streaming variational Bayes method for linear regression with autoregressive errors that combines online changepoint detection with sequential posterior inference. The proposed method processes observations in chronological mini-batches and uses a finite-mixture…

基于秩的模型平均估计量用于平均处理效应AI 解读

Model averaging emerges as an attractive ensemble technique that strategically synthesizes all available information from potential candidate models to enhance estimation accuracy. Despite of having been widely practiced in various areas in biostatistics and economics, its application to causal inference is rather limited. We propose to estimate the average treatment effect (ATE) by forming the weighted combination of the robust rank-based estimators obtained from a series…

自适应实验中策略改进价值的推断AI 解读

In this paper, we develop an asymptotically normal estimator for the value of policy improvement (VPI) under adaptively collected data. This value, which is defined as the gap between the value of the best treatment policy in a class and that of a baseline policy, gauges whether or not it is worth deploying a personalized treatment policy. Building an estimator for the VPI is naturally more difficult than estimating the value of a fixed policy. This is because, in addition…

异质性高维分位数回归的全局推断AI 解读

Quantile regression has received considerable attention in high dimensional methodology due to its robustness and ability to accommodate heteroskedasticity. Despite this attention, current inferential methods for high dimensional quantile regression have significant limitations---only testing significance, testing at a single quantile at a time, or assuming homoskedasticity. To generalize the inferences that can be drawn in high dimensional quantile regression, we introduce…