每日简报

溢出效应实验中的稳健信号最大化AI 解读

We study the optimal design and analysis of experiments for estimating spillover effects. Assuming a known (e.g., linear) exposure mapping, we characterize the treatment-assignment distribution and regression-based estimator that minimize worst-case asymptotic variance against a broad class of distributions of unobservables. The design problem yields an intuitive solution in which the planner trades off spillover signal strength against diffusion of spillover variation. The…

在电子健康记录表型算法中使用二元银标签AI 解读

Gold-standard phenotype labels are often unavailable at scale in electronic health record (EHR) studies because they require manual chart review. Weakly supervised phenotyping methods instead use silver-standard labels, such as diagnosis-code counts, natural language processing (NLP) mentions, medication indicators, or laboratory thresholds. PheNorm is widely used for this purpose, but its original formulation was designed for count-valued silver labels and relies on log…

面向多模态协变量的平面曲线深度形状回归AI 解读

The shape of a planar curve is the geometric information that remains once translation, rotation, scale and reparametrisation are removed and is of interest in many health applications, e.g. in neuroimaging. We propose a deep shape regression model for open planar curves that admits multimodal and high-dimensional covariates. Representing curves as complex-valued functions, we show that the conditional full Procrustes mean is the leading eigenfunction of the conditional…

重尾预测变量的球协差筛选AI 解读

High-dimensional screening is commonly built on covariance, correlation, or least-squares measures. These summary measures can be unstable or even undefined, when predictors are sparse or have heavy-tailed distributions. Building on our recent work on extended codifference and the idea of Ball-covariance, we develop Ball-codifference for marginal screening in statistical modeling with heavy-tailed predictors and responses. The proposed statistic combines the rank-type…

高维变点检测的椭圆正则化Hotelling检验AI 解读

We propose an elliptical regularized Hotelling (ERHT) procedure for detecting location changes in high-dimensional sequences with heavy-tailed, cross-sectionally dependent observations. ERHT contrasts spatial medians on adjacent segments using a ridge-regularized inverse of the pooled centered spatial-sign covariance matrix, thereby combining robustness to radial variation with dependence-aware weighting. We establish Gaussian-process limits for the single- and…

面向张量响应变量的一致特征筛选方法及其在全基因组面部形状关联中的应用AI 解读

As data collecting technologies advance, data structures are getting more and more complex, from single vectors to multi-dimensional tensors. This article is motivated by a variable selection problem to detect important genes from an ultrahigh dimensional pool that are associated with human facial shape variations. We propose a data-driven trimmed feature screening method based on a tensor ridge regression model (TrimTenRidge) through setting thresholds on the tensor…

超越负岭端点：经负移梯度下降的混合符号谱正则化AI 解读

In overparameterized linear regression, many weak spectral directions act like a ridge penalty on the signal-bearing spectrum; negative ridge is the natural correction, pushing filters above one. The stable negative-ridge endpoint, however, is structurally limited: its pole must stay below the smallest nonzero empirical eigenvalue, and it anti-shrinks smaller eigenvalues more than larger ones. Early-stopped negative-shifted gradient descent escapes this constraint. Its…

情境自适应推断：统计与基础模型的统一视角AI 解读

Modern predictive systems are expected to adapt their behavior to the specific situation they are facing. A clinical model should not treat every patient the same; a retrieval-augmented model should change its answer when given different evidence; a mixture-of-experts model should route different inputs to different experts. We call this capability context-adaptive inference: before predicting, the system uses information about the current context to specialize its…

共享支撑、异质边强度下的多精度矩阵估计AI 解读

Estimating multiple precision matrices in high-dimension presents significant challenges, particularly when distinct datasets share a common conditional dependency structure but exhibit population-specific interaction strengths. We address this problem by introducing the Multiplicative Graphical Lasso (Mglasso), a method for jointly estimating precision matrices across multiple Gaussian graphical models under a shared sparsity constraint. Each precision matrix is decomposed…

核岭回归用于函数矩估计的精确泛化误差曲线AI 解读

Kernel ridge regression is a standard method for functional data analysis, but its exact behavior is less understood. We study tensor-product kernel ridge regression for estimating the $r$-th moment function of a random function based on noisy discrete observations. The formulation includes mean estimation, covariance estimation, and higher-order moment estimation in a single framework. Our main result gives a precise $1+o_{\mathbb{P}}(1)$ expansion for the $L^2$ error at…

多元回归中高维残差协方差矩阵的受限非线性收缩AI 解读

We study estimation of the p*p residual scatter (shape) matrix in a high-dimensional multivariate linear regression, where p and n grow proportionally. When the coefficient matrix obeys a known linear restriction of rank q < d, as in multivariate analysis of variance, growth-curve models, and reduced-rank regression, the restricted fit leaves additional residual degrees of freedom that sharpen estimation of the shape matrix. To accommodate heavy-tailed errors, we work with…

去中心化网络上的分布式卷积秩回归AI 解读

This paper studies convolution rank regression (CRR) over decentralized distributed learning networks. We propose a novel decentralized CRR framework, in which estimators are obtained by solving consensus-constrained optimization with kernel-smoothed rank loss. The developed estimation scheme relies solely on local node data and information shared by neighboring nodes, thereby achieving privacy preservation and high communication efficiency. For heterogeneous network…

变分贝叶斯稀疏负二项回归AI 解读

Count data with overdispersion and high-dimensional predictors pose significant challenges in modern applications. While negative binomial regression offers a flexible modeling framework, existing Bayesian approaches rely on computationally expensive MCMC methods that become impractical in high-dimensional settings. This paper develops a variational Bayesian framework for sparse negative binomial regression using horseshoe and continuous spike-and-slab priors. Our proposed…

基于方差的治疗效应异质性检验AI 解读

This paper proposes a robust nonparametric hypothesis test for the existence of heterogeneous treatment effects. We focus on the variance of the Conditional Average Treatment Effect (CATE) as a natural omnibus parameter, where a non-zero variance implies the presence of relevant heterogeneity. Standard inference for this parameter faces a fundamental theoretical challenge. On one hand, evaluating variance components on the same sample leads to null degeneracy, where the…

非平稳时间序列局部化部分和的函数型中心极限定理AI 解读

A localized functional central limit theorem is established for kernel-weighted partial sum processes of piecewise locally stationary time series under geometric decay of the physical dependence measure. The localized process is shown to converge weakly to a centered Gaussian random distribution in $D'(0,1)$, and the limit extends naturally to an isonormal Gaussian process on $L^2([0,1])$. Weak convergence is further derived for processes indexed by totally bounded subsets…

网络元回归模型假设影响的模拟评估AI 解读

Network meta-regression (NMR) extends network meta-analysis (NMA) by synthesizing evidence on multiple treatments while adjusting for potential effect modifiers. By accounting for effect modification, NMR can reduce between-study heterogeneity and improve the validity of relative treatment effects, providing insight regarding characteristics impacting treatment performance. However, choosing between available NMR models is complex, as each model addresses a similar, but…

时变混杂下平均处理效应估计的缺失数据方法比较AI 解读

Missing data and confounding are common in real-world statistical applications, yet few studies have examined how imputation methods perform under time-varying confounding in binary variables, or how missingness mechanism, missing rate, missingness location and sample size jointly affect performance and the underlying identifiability conditions. We generated synthetic data and conducted a simulation study comparing missing data methods across scenarios varying these factors.…

ATLAS：异质环境中不变且可迁移潜在因子的识别AI 解读

This paper considers a multi-environment factor model in which high-dimensional covariates are collected from heterogeneous environments, with auxiliary labels available in a subset of these environments. The joint distribution of the covariates may vary across environments, whereas the latent structure is decomposed into invariant factors with shared loadings and heterogeneous factors with environment-specific loadings. Such a model is motivated by transfer learning and…

向量检索作为最近邻匹配：因果推断中的 RAG 政策学习AI 解读

We propose one-step and two-step methods for policy learning with retrieval-augmented generation (RAG). We formulate RAG-based action selection under the potential outcome framework. In the two-step method, vector search retrieves action-specific neighboring evidence in an embedding space, the generator estimates conditional expected outcomes or their contrasts, and a plug-in rule selects an action. This formulation connects action-specific vector search with…

不规则时间序列的因果发现AI 解读

Causal discovery methods have shown strong performance in temporal systems, but they typically rely on regular and discrete lag structures, limiting their applicability to regularly sampled data. However, many real-world tasks require dealing with irregularly sampled streams of events, such as sensor streams, healthcare data, and financial transactions. In this work, we propose an extension of PCMCI+, a state-of-the-art method for causal discovery on regular multivariate…

SPYCE：结果依赖删失下早期亨廷顿病终点的双重稳健估计AI 解读

Clinical trials for neurodegenerative diseases must identify sensitive endpoints -- outcomes that change rapidly enough to detect treatment effects. In Huntington disease, this requires measuring how outcomes change as participants approach Stage 1. Yet many participants exit studies before reaching this stage, making their time to Stage 1 right-censored. Estimating how outcomes change requires models for both time to Stage 1 and time to study exit. When participants with…

两样本孟德尔随机化的自适应惩罚与自助平滑推断AI 解读

Two-sample Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects from observational data using summary association statistics. However, horizontal pleiotropy can invalidate standard MR estimators and lead to biased causal inference. Pleiotropy-robust methods have been proposed to address this issue, including regularization-based approaches such as MR-Lasso. However, MR-Lasso may fail to identify invalid instruments…

因果治愈模型的贝叶斯方法AI 解读

Time-to-event data often include individuals who will never experience the failure event, and are therefore considered cured. In such settings, frequently encountered in clinical research, a substantial proportion of patients may remain event-free throughout the observation period, leading to the appearance of a survival plateau that is commonly interpreted as evidence of a cured fraction. Analysing such data requires inference on the cure fraction and on the survival…

稠密测量误差下的网络溢出效应估计AI 解读

This paper analyzes spillover effects in spatial (network) models when the neighborhood (adjacency) matrix is contaminated by measurement error from reporting, aggregation, or disclosure imperfections, leading to inconsistent estimation of network effects. We introduce a regularization framework for the latent network that allows for sparse and/or low-rank structure and accommodates potential correlation between measurement errors and outcomes. We propose two estimators: (i)…