每日简报

样本个体数为一时的实验设计AI 解读

N-of-1 trials, or time-series experiments, are widely used in clinical research and online platforms. Yet the theoretically optimal design for estimating many treatment effects remains unclear. We propose a simple Markovian framework for experimental design in which the treatment assignment process is governed by possibly time-varying transition matrices. This formulation encompasses many existing N-of-1 designs and provides a principled way to control temporal dependence in…

分位数回归模型中的双向聚类稳健方差估计AI 解读

We study inference for linear quantile regression with two-way clustered data. Using a separately exchangeable array framework and a projection decomposition of the quantile score, we characterize regime-dependent convergence rates and establish a self-normalized Gaussian approximation. We propose a two-way cluster-robust sandwich variance estimator with a kernel-based density ``bread'' and a projection-matched ``meat'', and prove consistency and validity of inference in…

核工具变量回归的一致推断AI 解读

Instrumental variable regression is a foundational tool for causal analysis across the social and biomedical sciences. Recent advances use kernel methods to estimate nonparametric causal relationships, with general data types, while retaining a simple closed-form expression. Empirical researchers ultimately need reliable inference on causal estimates; however, uniform confidence sets for the method remain unavailable. To fill this gap, we develop valid and sharp confidence…

因果估计中的两层不稳定性AI 解读

There is a precise sense in which drawing causal inferences from observational data is hard, even when identifiability is assumed. In particular, Robins and Ritov (1997) and Robins et al. (2003) showed that causal effects can be discontinuous as a function of the data distribution: two arbitrarily close data distributions might correspond to different causal effects. This is a fact independent of the choice of estimator; however, not all estimators are equally unstable. Our…

忽略面板非线性导致的弱工具变量：Super Learner 控制函数估计AI 解读

A triangular structural panel data model with additive separable individual-specific effects is used to model the causal effect of a covariate on an outcome variable when there are unobservable confounders with some of them time-invariant. In this setup, a linear specification for the reduced-form equation might be problematic when the conditional mean of the endogenous covariate and the instrumental variables is nonlinear in the population. The reason is that ignoring the…

异质性下以百分点表示的平均处理效应估计与推断AI 解读

In semi-logarithmic regressions, treatment coefficients are often interpreted as approximations of an average treatment effect (ATE) in percentage points. This paper highlights the overlooked bias of this approximation under treatment effect heterogeneity, arising from Jensen's inequality. The issue is particularly relevant for difference-in-differences designs with log-transformed outcomes and staggered treatment adoption, where treatment effects may vary across groups and…

断点回归设计中的灵活协变量调整AI 解读

Empirical regression discontinuity (RD) studies often include covariates in their specifications to increase the precision of their estimates. In this paper, we propose a novel class of estimators that use such covariate information more efficiently than existing methods and can accommodate many covariates. Our estimators are simple to implement and involve running a standard RD analysis after subtracting a function of the covariates from the original outcome variable. We…

随机临床试验中协变量调整 g-computation 的偏差减少AI 解读

G-computation is a powerful method for estimating unconditional treatment effects with covariate adjustment in randomized clinical trials. It typically relies on fitting canonical generalized linear models. However, this could be problematic when the sample size or event number is small relative to the number of covariates. Common issues include the underestimation of the variance and the potential nonexistence of maximum likelihood estimators. Bias reduction methods are…

固定簇内重复抽取不同个体以提高纵向估计精度：DISC 设计AI 解读

Background: Longitudinal studies often involve repeated cluster sampling of a population at multiple time points, such as in difference-in-differences (DID) studies. Although cohort designs typically lead to more efficient estimators relative to repeated cross-sectional (RCS) designs, they are often impractical. Methods: We describe the DISC (Different Individuals, Same Clusters) design, a sampling scheme that improves the precision of estimators in these settings. The DISC…