每日简报

缺失数据下纵向随机试验终点胜出概率的秩方法AI 解读

The primary analysis for longitudinal randomized controlled trials (RCTs) often compares treatment groups at the last timepoint, referred to as the landmark time. Assuming data are normally distributed and missing at random, the mixed model for repeated measures (MMRM) is widely used to conduct inference in terms of a mean difference. When outcomes violate normality assumption and/or the mean difference lacks a clear interpretation, we may quantify treatment effects using…

参数与半参数方法下的变量选择与响应误分类AI 解读

While variable selection has received extensive attention in the literature, its exploration in the presence of response measurement error remains underexplored. In this paper, we investigate this important problem within the context of binary classification with error-prone responses. We present valid variable selection procedures to address the complexities of response errors. Leveraging validation data, we introduce both parametric and semiparametric methodologies to…

遗传工具变量下边际处理效应的有效半参数估计AI 解读

Alcohol misuse is a key target of public health strategies aimed at reducing cardiovascular risk. The effect of excessive alcohol consumption on blood pressure may vary systematically with individuals' unobserved propensity to engage in heavy drinking, complicating causal inference with observational data. The marginal treatment effects framework uses an instrumental variable for treatment choice (excessive alcohol consumption) to study how selection into treatment is linked…

主层可忽略性下异质主层效应的估计AI 解读

We study estimation and inference for heterogeneous principal causal effects with binary treatments and binary intermediate variables. Principal causal effects are subgroup effects within strata defined by potential values of an intermediate variable, including effects among compliers. We propose a framework for estimating and forming pointwise confidence intervals for heterogeneous principal causal effects under the principal ignorability assumption. Several estimators are…

实现共同随机数：用于因果有效随机模型的事件键控哈希AI 解读

Agent-based models (ABMs) are widely used to estimate causal treatment effects via paired counterfactual simulation. A standard variance reduction technique is common random numbers (CRNs), which couples replicates across intervention scenarios by sharing the same random inputs. In practice, CRNs are implemented by reusing the same base seed, but this relies on a critical assumption: that the same draw index corresponds to the same modeled event across scenarios. Stateful…

通过风险时间拆分改进筛查项目对后续死亡率影响的估计AI 解读

There is a great need for evaluating screening programs, but analysing data from population screening is often complicated by a delayed screening effect. In cancer screening, only new, not yet clinically diagnosed cases, might benefit from screening through earlier treatment. Hence, mortality data following screening should be analysed based on refined mortality, separating cases based on diagnosis before and after first screening invitation. Historically, refined mortality…

广告个性化中位置追踪的隐私与效用权衡AI 解读

Firms collect vast amounts of behavioral and geographical data on individuals. While behavioral data captures an individual's digital footprint, geographical data reflects their physical footprint. Given the significant privacy risks associated with combining these data sources, it is crucial to understand their respective value and whether they act as complements or substitutes in achieving firms' business objectives. In this paper, we combine economic theory, machine…

异质弹性、聚合与重转换偏差AI 解读

Economists often interpret estimates from linear regressions with log dependent variables as elasticities. However, the coefficients from log-log regressions estimate the elasticity of the geometric mean of $y_i|x_i$, not the arithmetic mean. The unbounded difference between the two is known as retransformation bias and can take either sign. We develop a specification-robust debiased estimator of the average arithmetic elasticity and re-estimate 50 results from top 5 papers…

带子群选择的两阶段自适应设计置信区间AI 解读

We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs allow the enrolled population to be modified at an interim analysis, with subpopulations selected according to preplanned rules. Since these interim decisions are data-dependent, valid statistical inference must account for them. We focus on constructing confidence intervals for the treatment effect…

大规模因果推断中核估计量的快速不确定性量化AI 解读

Kernel methods are widely used in causal inference for tasks such as treatment effect estimation, policy evaluation, and policy learning. The bootstrap is a standard tool for uncertainty quantification because of its broad applicability. As increasingly large datasets become available, such as the 2023 U.S. Natality data from the National Vital Statistics System (NVSS), which includes 3,596,017 registered births, the computational demands of these methods increase…

替代标志物评价中秩方法的贝叶斯批评AI 解读

Surrogate markers are often employed in clinical trials to replace primary outcomes that may be difficult, expensive, or time-consuming to measure directly. These markers can accelerate the evaluation of new treatments, provided they reliably capture the causal relationship between treatment and true clinical benefit. Parast et al. (2024) recently proposed a rank-based approach for evaluating surrogate markers, characterized by its nonparametric nature and minimal…

含随机效应与固定效应的空间面板模型梯度提升AI 解读

Due to the increase in data availability in urban and regional studies, various spatial panel models have emerged to model spatial panel data, which exhibit spatial patterns and spatial dependencies between observations across time. Although estimation is usually based on maximum likelihood or generalized method of moments, these methods may fail to yield unique solutions if researchers are faced with high-dimensional settings. This article proposes a model-based gradient…

基于分布等价性先检验后合并的数据融合AI 解读

Randomized controlled trials (RCTs) are the gold standard for causal inference, yet practical constraints often limit the size of the concurrent control arm. Borrowing control data from previous trials offers a potential efficiency gain, but naive borrowing can induce bias when historical and current populations differ. Existing test-then-pool (TTP) procedures address this concern by testing for equality of control outcomes between historical and concurrent trials before…

含未观测异质性的策略性网络形成模型的可处理识别方法AI 解读

We develop a tractable identification approach for strategic network formation models with both strategic link interdependence and individual unobserved heterogeneity (fixed effects). The key challenge is that endogenous network statistics (e.g. number of common friends) enter the link formation equation, while the mapping from model primitives to equilibrium network structure is generally intractable. Our approach sidesteps this difficulty using a ``bounding-by-$c$''…

因果基础模型的干预时间序列先验AI 解读

Prior-data fitted networks (PFNs) have emerged as powerful foundation models for tabular causal inference, yet their extension to time series remains limited by the absence of synthetic data generators that provide interventional targets. Existing time series benchmarks generate observational data with ground-truth causal graphs but lack the interventional data required for training causal foundation models. To address this, we propose \textbf{CausalTimePrior}, a principled…

可解释 M 学习器框架下的生存分析异质性中介效应AI 解读

Mediation analysis is a useful tool to evaluate surrogate endpoints in clinical trials. We propose a novel method, the M-survival learner, for estimating heterogeneous indirect treatment effects in the presence of censored outcomes. The proposed approach enables the identification of interpretable patient subgroups characterized by distinct mediation pathways. To distinguish heterogeneous from homogeneous mediation effects, we introduce a new statistical criterion…

复杂处理下采用最优压缩的因果表示学习AI 解读

Estimating Individual Treatment Effects (ITE) in multi-treatment scenarios faces two critical challenges: the Hyperparameter Selection Dilemma for balancing weights and the Curse of Dimensionality in computational scalability. This paper derives a novel multi-treatment generalization bound and proposes a theoretical estimator for the optimal balancing weight $α$, eliminating expensive heuristic tuning. We investigate three balancing strategies: Pairwise, One-vs-All (OVA),…

时变行动下处理复发事件与半竞争事件的新型 g 计算算法AI 解读

Background: A core aspect of epidemiology is determining the impacts of potential public health interventions over time. With long follow-up periods, epidemiologists may need to consider semi-competing events, in which a terminal event, like death, precludes a non-terminal event, like hypertension. Time-varying confounding poses an additional challenge when studying time-varying interventions or actions. Existing methods do not simultaneously address semi- competing events…

利用历史汇总数据支持个体化治疗建议的贝叶斯自适应富集设计AI 解读

Adaptive enrichment trials aim to identify and recruit participants most likely to benefit from treatment based on evolving biomarker evidence, with the goal of informing individualized treatment recommendations. Bayesian methods are well suited to these designs because they allow external information to be incorporated in a principled manner. In practice, prior studies often provide only summary-level information, with subgroup-specific estimates unavailable due to design…

超越均值：持久同调可忽略性下的拓扑因果效应AI 解读

Average treatment effects (ATE) and conditional average treatment effects (CATE) are foundational causal estimands, but they target changes in expected outcomes and can miss treatment-induced changes in the shape of outcome distributions. A canonical failure mode occurs when control outcomes are unimodal, treated outcomes become bimodal, and both distributions have the same mean. In such cases mean-based causal estimands are zero even though the geometry and topology of the…

平稳随机动力系统中因果效应符号的可识别性AI 解读

We study identifiability in continuous-time linear stationary stochastic differential equations with a known causal structure. Unlike existing approaches, we relax the assumption of a known diffusion matrix, thereby respecting the model's intrinsic scale invariance. Therefore, rather than recovering drift coefficients themselves, we introduce edge-sign identifiability: for a given causal structure, we ask whether the sign of a given drift entry is uniquely determined across…

使用非同期对照的平台试验因果生存分析AI 解读

Platform trials allow treatment arms to enter and exit over time while maintaining a shared control arm, yielding concurrent and non-concurrent controls (NCC). Pooling NCC is often motivated as a strategy to improve statistical efficiency, but it is unclear which estimand is targeted, what assumptions justify identification and estimation, and when precision gains are achievable; these questions are further complicated by time-to-event/survival data. Motivated by the…

行政删失下利用短期替代指标半参数估计延迟结果处理效应AI 解读

The multi-site registry studies, such as Stepped-wedge cluster-randomized trials (SW-CRT), staggered-enrollment RCTs, etc., share a structural feature: the primary long-term outcome is administratively censored for a non-negligible fraction of units, with censoring driven by calendar design rather than by the outcome itself. Standard inverse-probability-of-censoring weighting becomes unstable when observation probabilities $g_Δ$ concentrate near zero for late-crossing units,…

具有潜在转移异质性的离散结果事件研究设计AI 解读

We develop an identification strategy for average treatment effects on the treated (ATT) in panel data with discrete outcomes. For such outcomes, the parallel trends assumption underlying difference-in-differences (DiD) fails in three distinct ways: mean reversion generates divergent trends when groups differ at baseline, counterfactual probabilities can leave the unit interval, and no single trend is well defined for multi-category outcomes. We replace parallel trends with…