Improving operating characteristics of clinical trials by augmenting control arm using propensity score-weighted borrowing-by-parts power prior
利用倾向得分加权与分部借用幂先验增强临床试验对照组
Borrowing external data can improve estimation efficiency but may introduce bias when populations differ in covariate distributions or outcome variability. A proper balance needs to be maintained between the two datasets to justify the borrowing. We propose a propensity score weighting borrowing-by-parts power prior (PSW-BPP) that integrates causal covariate adjustment through propensity score weighting with a flexible Bayesian borrowing approach to address these challenges…