每日简报

利用大量含噪代理变量进行长期因果推断AI 解读

We propose a method for estimating long-term treatment effects with many short-term proxy outcomes: a central challenge when experimenting on digital platforms. We formalize this challenge as a latent variable problem where observed proxies are noisy measures of a low-dimensional set of unobserved surrogates that mediate treatment effects. Through theoretical analysis and simulations, we demonstrate that regularized regression methods substantially outperform naive proxy…

考虑时间结构的合成控制AI 解读

The synthetic control (SC) framework is widely used for observational causal inference with time-series panel data. SC has been successful in diverse applications, but existing methods typically treat the ordering of pre-intervention time indices interchangeable. This invariance means they may not fully take advantage of temporal structure when strong trends are present. We propose Time-Aware Synthetic Control (TASC), which employs a state-space model with a constant trend…

异质系数面板模型中的经验贝叶斯估计AI 解读

We develop an empirical Bayes (EB) G-modeling framework for short-panel linear models with nonparametric prior for the random intercepts, slopes, dynamics, and non-spherical error variances. We establish identification and consistency of the nonparametric maximum likelihood estimator (NPMLE) under general conditions, and provide low-level sufficient conditions for several models of empirical interest. Conditions for regret consistency of the EB estimators are also…

测量误差下凹分布函数的推断AI 解读

We propose an estimator of a concave cumulative distribution function under the measurement error model, where the non-negative variables of interest are perturbed by additive independent random noise. The estimator is defined as the least concave majorant on the positive half-line of the deconvolution estimator of the distribution function. We show its uniform consistency and its square root convergence in law in $\ell_\infty(\mathbb R)$. To assess the validity of the…

条件函数图模型中识别差异网络的近邻选择方法AI 解读

Estimating how different brain regions communicate with each other using EEG data is valuable both for medical research and clinical diagnosis. This involves quantifying the statistical dependencies among the activities of different brain areas, captured by the time-varying electric field recorded by scalp sensors. These dependencies can vary within and across individuals also in relationship with external factors such as age, mental state, or disease severity. Motivated by…

使用稳健 MAP 先验评估区域处理效应AI 解读

Bayesian dynamic borrowing has become an increasingly important tool for evaluating the consistency of regional treatment effects which is a key requirement for local regulatory approval of a new drug. It helps increase the precision of regional treatment effect estimate when regional and global data are similar, while guarding against potential bias when they differ. In practice, the two-component mixture prior, of which one mixture component utilizes the power prior to…

基于强化学习的高效动态离散选择模型条件选择模拟估计AI 解读

Dynamic discrete choice (DDC) models have found widespread application in marketing. However, estimating these becomes challenging in "big data" settings with high-dimensional state-action spaces. To address this challenge, this paper develops a Reinforcement Learning (RL)-based two-step ("computationally light") Conditional Choice Simulation (CCS) estimation approach that combines the scalability of machine learning with the transparency, explainability, and…

目标试验模拟中的目标估计量AI 解读

The target trial framework enables causal inference from longitudinal observational data by emulating randomized trials initiated at multiple time points. Precision is often improved by pooling information across trials, with standard models typically assuming - among other things - a time-constant treatment effect. However, this obscures interpretation when the true treatment effect varies, which we argue to be likely as a result of relying on noncollapsible estimands. To…

以分位数为目标的有限样本极小极大遗憾处理规则AI 解读

Consider a setup in which a decision maker is informed about the population by a finite sample and based on that sample has to decide whether or not to apply a certain treatment. We work out finite sample minimax regret treatment rules under various sampling schemes when outcomes are restricted onto the unit interval. In contrast to Stoye (2009) where the focus is on maximization of expected utility the focus here is instead on a particular quantile of the outcome…

利用倾向得分加权与分部借用幂先验增强临床试验对照组AI 解读

Borrowing external data can improve estimation efficiency but may introduce bias when populations differ in covariate distributions or outcome variability. A proper balance needs to be maintained between the two datasets to justify the borrowing. We propose a propensity score weighting borrowing-by-parts power prior (PSW-BPP) that integrates causal covariate adjustment through propensity score weighting with a flexible Bayesian borrowing approach to address these challenges…

嵌套病例对照研究加权分析中的纳入概率估计AI 解读

Nested case-control (NCC) studies are a widely adopted design in epidemiology to investigate exposure-disease relationships. This paper examines weighted analyses in NCC studies, focusing on two prominent weighting methods: Kaplan-Meier (KM) weights and Generalized Additive Model (GAM) weights. We consider three target estimands: log-hazard ratios, conditional survival, and associations between exposures. While KM- and GAM-weights are generally robust, we identify specific…

高维双向固定效应回归的岭估计AI 解读

We study a ridge estimator for the high-dimensional two-way fixed effect regression model with a sparse bipartite network. We develop concentration inequalities showing that when the ridge parameters increase as the log of the network size, the bias, and the variance-covariance matrix of the vector of estimated fixed effects converge to deterministic equivalents that depend only on the expected network. We provide simulations and an application using administrative data on…

用高斯求积计算因果推断模拟研究中的真实目标值AI 解读

Simulation studies are used to understand the properties of statistical methods. A key luxury in many simulation studies is knowledge of the true value (i.e. the estimand) being targeted. With this oracle knowledge in-hand, the researcher conducting the simulation study can assess across repeated realizations of the data how well a given method recovers the truth. In causal inference simulation studies, the truth is rarely a simple parameter of the statistical model chosen…

存在反馈的事件研究AI 解读

Event studies often conflate direct treatment effects with indirect effects operating through endogenous covariate adjustment. We develop a dynamic panel event study framework that separates these effects. The framework allows for persistent outcomes and treatment effects and for covariates that respond to past outcomes and treatment exposure. Under sequential exogeneity and homogeneous feedback, we establish point identification of common parameters governing outcome and…

利用图卷积自编码器学习并检验干扰的暴露映射AI 解读

Interference or spillover effects arise when an individual's outcome (e.g., health) is influenced not only by their own treatment (e.g., vaccination) but also by the treatment of others, creating challenges for evaluating treatment effects. Exposure mappings provide a framework to study such interference by explicitly modeling how the treatment statuses of contacts within an individual's network affect their outcome. Most existing research relies on a priori exposure…

从分类视角利用自适应 LASSO 估计可解释的最优个体化治疗规则AI 解读

Real-world data (RWD) gains growing interests to provide a representative sample of the population for selecting the optimal treatment options. However, existing complex black box methods for estimating individualized treatment rules (ITR) from RWD have problems in interpretability and convergence. Providing an interpretable and sparse ITR can be used to overcome the limitation of existing methods. We developed an algorithm using Adaptive LASSO to predict optimal…

观察研究中估计个体化治疗规则的降维结局加权学习AI 解读

Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy, interpretability, and real-world applicability. We propose a novel sufficient dimension reduction approach that directly targets the contrast between potential outcomes and identifies a low-dimensional subspace of the covariates capturing…

带连续标记的删失数据因果推断AI 解读

This paper presents a framework for causal inference in the presence of censored data,where the failure time is marked by a continuous variable referred to as a mark.The mark is observed after treatment and is not meaningful when the failure time is censored. In addition, due to the continuous nature of the marks, observations at each given mark are sparse. These facts make the identification and estimation of causality a challenging task. To address these issues, we define…

利用代理变量与工具变量处理 Perturb-seq 中的未观测混杂AI 解读

Emerging single-cell technologies that combine CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, offer unprecedented opportunities to uncover cause-and-effect relationships among genes. Nonetheless, Perturb-seq experiments are subject to unobserved factors that, if not properly handled, can severely bias the inferred causal relationships between genes. These latent factors may arise not only from intrinsic molecular features of the…

从非结构化数据到需求反事实：理论与实践AI 解读

Empirical models of multi-product demand rely on low-dimensional product representations to capture substitution patterns, increasingly using proxies built from unstructured data. When proxies are imperfect, standard workflows yield biased counterfactuals and invalid inference. We develop a practical toolkit to address these issues. Our methods apply to market-level and/or individual data, require minimal additional computation, provide simple standard-error formulas, and…

潜在因子模型中的网络依赖检测：偏误修正 CD 检验AI 解读

In a recent paper Juodis and Reese (2022) (JR) show that the application of the CD test proposed by Pesaran (2004) to residuals from panels with latent factors results in over-rejection. They propose a randomized test statistic to correct for over-rejection, and add a screening component to achieve power. This paper considers the same problem but from a different perspective, and shows that the standard CD test remains valid if the latent factors are weak in the sense the…

无条件分位数效应的敏感性分析AI 解读

This paper proposes a framework to analyze the effects of counterfactual policies on the unconditional quantiles of an outcome variable. For a given counterfactual policy, we obtain identified sets for the effect of both marginal and global changes in the proportion of treated individuals. To conduct a sensitivity analysis, we introduce the quantile breakdown frontier, a curve that (i) indicates whether a sensitivity analysis is possible or not, and (ii) when a sensitivity…

集群随机试验中间接效应与溢出效应的半参数因果中介分析AI 解读

In cluster-randomized trials (CRTs), there is emerging interest in exploring the causal mechanism in which a cluster-level treatment affects the outcome through an intermediate outcome. The majority of existing causal mediation methods are applicable to independent data and only a few exceptions have considered assessing causal mediation in CRTs, all of which heavily depend on parametric assumptions. In this article, we develop a formal semiparametric efficiency theory to…

用于随机试验与外部数据混合研究的实验选择交叉验证 TMLEAI 解读

Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined with external data) with the optimal bias-variance tradeoff, we develop a novel experiment-selector cross-validated targeted maximum likelihood estimator for randomized-external data studies (ES-CVTMLE). This estimator utilizes two estimates of bias to determine whether to integrate external data…