Sequential Randomization Tests Using e-values: Applications for trial monitoring
基于 e 值的序贯随机化检验及试验监测
Sequential monitoring of randomized trials traditionally relies on parametric assumptions or asymptotic approximations. We discuss a family of nonparametric sequential tests - collectively called e-RT - for binary, event-only, and continuous endpoints. All active variants derive validity from the randomization mechanism. Using a betting framework, each test constructs a test martingale by sequentially wagering on randomized assignments or observed event labels before using…