每日简报

有限流动下双向效应的最优估计AI 解读

We propose an empirical Bayes estimator for two-way effects in linked data sets based on a novel prior that leverages patterns of assortative matching observed in the data. To capture limited mobility we model the bipartite graph associated with the matched data in an asymptotic framework where its Laplacian matrix has small eigenvalues that converge to zero. The prior hyperparameters that control the shrinkage are determined by minimizing an unbiased risk estimate. We show…

密集纵向数据的动态因果中介分析AI 解读

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways between time-varying exposures, time-varying mediators, and a final, distal outcome using such data. Addressing mediation questions in these settings is challenging due to numerous potential exposures, complex mediation pathways, and…

确定性离散线性时不变微分代数系统中的因果发现AI 解读

Discovering pure causes or driver variables in deterministic LTI systems is of vital importance in the data-driven reconstruction of causal networks. A recent work by Kathari and Tangirala, proposed in 2022, formulated the causal discovery method as a constraint identification problem. The constraints are identified using a dynamic iterative PCA (DIPCA)-based approach for dynamical systems corrupted with Gaussian measurement errors. The DIPCA-based method works efficiently…

半竞争风险的贝叶斯非参数方法及心血管健康应用AI 解读

We address causal estimation in semi-competing risks settings, where a non-terminal event may be precluded by one or more terminal events. We define a principal-stratification causal estimand for treatment effects on the non-terminal event, conditional on surviving past a specified landmark time. To estimate joint event-time distributions, we employ both vine-copula constructions and Bayesian nonparametric Enriched Dirichlet-process mixtures (EDPM), enabling inference under…

基于 Transformer 的时空反事实结局估计AI 解读

The real world naturally has dimensions of time and space. Therefore, estimating the counterfactual outcomes with spatial-temporal attributes is a crucial problem. However, previous methods are based on classical statistical models, which still have limitations in performance and generalization. This paper proposes a novel framework for estimating counterfactual outcomes with spatial-temporal attributes using the Transformer, exhibiting stronger estimation ability. Under…

因子模型学习所得潜在结局的因果推断AI 解读

In many fields$\unicode{x2013}$including genomics, epidemiology, natural language processing, social and behavioral sciences, and economics$\unicode{x2013}$it is increasingly important to address causal questions in the context of factor models or representation learning. In this work, we investigate causal effects on $\textit{latent outcomes}$ derived from high-dimensional observed data using nonnegative matrix factorization. To the best of our knowledge, this is the first…

两阶段抽样下结局与处理均有测量误差的高效因果效应估计AI 解读

Measurement error is a common challenge for causal inference studies using electronic health record (EHR) data, where clinical outcomes and treatments are frequently mismeasured. Researchers often address measurement error by conducting manual chart reviews to validate measurements in a subset of the full EHR data -- a form of two-phase sampling. To improve efficiency, phase-two samples are often collected in a biased manner dependent on the patients' initial, error-prone…

暴露与混杂变量不完整时的平均因果效应估计AI 解读

Standard methods for estimating average causal effects require complete observations of the exposure and confounders. In observational studies, however, missing data are ubiquitous. Motivated by a study on the effect of prescription opioids on mortality, we propose methods for estimating average causal effects when exposures and potential confounders may be missing. We consider missingness at random and additionally propose several specific missing not at random (MNAR)…

连续处理下随机对象结局因果效应的双重稳健估计AI 解读

Causal inference is central to statistics and scientific discovery, enabling researchers to identify cause-and-effect relationships beyond associations. While traditionally studied within Euclidean spaces, contemporary applications increasingly involve complex, non-Euclidean data structures that reside in abstract metric spaces, known as random objects, such as images, shapes, networks, and distributions. This paper introduces a novel framework for causal inference with…

连续处理面板数据中的因果推断AI 解读

This paper proposes a framework that incorporates the two-way fixed effects model as a special case to conduct causal inference with a continuous treatment. Treatments are allowed to change over time and potential outcomes are dependent on historical treatments. Regression models on potential outcomes, along with the sequentially conditional independence assumptions (SCIAs) are introduced to identify the treatment effects, which are measured by aggre causal responses. Least…

P-CRE-DML：非线性面板数据因果推断的新方法AI 解读

This paper introduces a novel Proxy-Enhanced Correlated Random Effects Double Machine Learning (P-CRE-DML) framework to estimate causal effects in panel data with non-linearities and unobserved heterogeneity. Combining Double Machine Learning (DML, Chernozhukov et al., 2018), Correlated Random Effects (CRE, Mundlak, 1978), and lagged variables (Arellano & Bond, 1991) and innovating within the CRE-DML framework (Chernozhukov et al., 2022; Clarke & Polselli, 2025; Fuhr &…

网络实验中的设计不确定性与网络抽样不确定性AI 解读

Ordinary least squares (OLS) estimators are widely used in network experiments to estimate spillover effects. We study the causal interpretation of, and inference for the OLS estimator under both design-based uncertainty from random treatment assignment and sampling-based uncertainty in network links. We show that correlations among regressors that capture the exposure to neighbors' treatments can induce contamination bias, preventing OLS from aggregating heterogeneous…

最优治疗规则与个体化干预因果分解的模拟敏感性分析AI 解读

Causal decomposition analysis aims to assess the effect of modifying risk factors on reducing social disparities in outcomes. Recently, this analysis has incorporated individual characteristics when modifying risk factors by utilizing optimal treatment regimes (OTRs). Since the newly defined individualized effects rely on the no omitted confounding assumption, developing sensitivity analyses to account for potential omitted confounding is essential. Moreover, OTRs and…

分离多个变量之间的共同网络依赖AI 解读

When two variables depend on the same or similar underlying network, their shared network dependence structure can lead to spurious associations. While statistical associations between two variables sampled from interconnected subjects are a common inferential goal across various fields, little research has focused on how to disentangle shared dependence for valid statistical inference. We revisit two different approaches from distinct fields that may address shared network…

网络因果效应的自回归双重稳健估计AI 解读

This paper develops new methods for causal inference in observational studies on a single large network of interconnected units, addressing two key challenges: long-range dependence among units and the presence of general interference. We introduce a novel network version of Augmented Inverse Propensity Weighted, which combines propensity score and outcome models defined on the network to achieve doubly robust identification and estimation of both direct and spillover causal…

聚合处理变量的因果推断AI 解读

In this paper, we study causal inference when the treatment variable is an aggregation of multiple sub-treatment variables. Researchers often report marginal causal effects for the aggregated treatment, implicitly assuming that the target parameter corresponds to a well-defined average of sub-treatment effects. We show that, even in an ideal scenario for causal inference such as random assignment, the weights underlying this average have some key undesirable properties: they…

自适应实验中的随时有效推断：协变量调整与功效平衡AI 解读

Adaptive experiments such as multi-armed bandits offer efficiency gains over traditional randomized experiments but pose two major challenges: invalid inference on the Average Treatment Effect (ATE) due to adaptive sampling and low statistical power for sub-optimal treatments. We address both issues by extending the Mixture Adaptive Design framework (arXiv:2311.05794). First, we propose MADCovar, a covariate-adjusted ATE estimator that is unbiased and preserves anytime-valid…

终末事件截断复发事件的主层分析：嵌套贝叶斯非参数方法AI 解读

Recurrent events often serve as key endpoints in clinical studies but may be prematurely truncated by terminal events such as death, creating selection bias and complicating causal inference. To address this challenge, we develop a Bayesian nonparametric framework to address potential selection bias due to truncation by death within the continuous-time principal stratification framework. We introduce causal estimands for recurrent events in the presence of a terminal event…

协同干预的因果分解分析：处理多维社会差距的三重稳健机器学习方法AI 解读

Educational disparities are rooted in and perpetuate social inequalities across multiple dimensions such as race, socioeconomic status, and geography. To reduce disparities, most intervention strategies focus on a single domain and frequently evaluate their effectiveness by using causal decomposition analysis. However, a growing body of research suggests that single-domain interventions may be insufficient for individuals marginalized on multiple fronts. While interventions…

事件时间终点缺失数据的临界点敏感性分析：模型法与经验法AI 解读

Treatment policy estimands are frequently favored by regulators, as they assess the effect of treatment assignment regardless of post-randomization events. Despite best efforts, missing data due to study discontinuation cannot be fully avoided and, for time-to-event endpoints, typically manifests as right censoring. Study discontinuation is often more likely following intercurrent events, particularly when it coincides with treatment discontinuation, raising concerns about…

基于贝叶斯非参数联合模型的连续时间纵向与生存数据因果中介分析AI 解读

Observational cohort data is an important source of information for understanding the causal effects of treatments on survival and the degree to which these effects are mediated through changes in disease-related risk factors. However, these analyses are often complicated by irregular data collection intervals and the presence of longitudinal confounders and mediators. We propose a causal mediation framework that jointly models longitudinal exposures, confounders, mediators,…

通过隐含干预进行因果推断AI 解读

In the context of having an instrumental variable, the standard practice in causal inference begins by targeting an effect of interest and proceeds by formulating assumptions enabling its identification. We turn this around by adhering to the interventions the observational distribution allows to identify, rather than starting with a desired causal estimand and imposing untestable conditions. The randomization of an instrument and its exclusion restriction define a class of…

传统分解与因果分解何时分歧？健康差异研究的实用指南AI 解读

Identifying malleable factors that can reduce social disparities is a central objective among researchers across disciplines. Traditionally, researchers have relied on the difference-in-coefficients and Kitagawa-Oaxaca-Blinder frameworks. More recently, methods grounded in the potential outcomes framework have emerged. While these methods share the same goal of identifying drivers of disparity, they frequently yield divergent results depending on the underlying confounding…

秘鲁矿业米塔制度的持久影响：双重机器学习方法AI 解读

This study examines the long-term economic impact of the colonial Mita system in Peru, building on Melissa Dell's foundational work on the enduring effects of forced labor institutions. The Mita, imposed by the Spanish colonial authorities from 1573 to 1812, required indigenous communities within a designated boundary to supply labor to mines, primarily near Potosi. Dell's original regression discontinuity design (RDD) analysis, leveraging the Mita boundary to estimate the…