每日简报

分布工具变量方法AI 解读

The instrumental variable (IV) approach is commonly used to infer causal effects in the presence of unmeasured confounding. Existing methods typically aim to estimate the mean causal effects, whereas a few other methods focus on quantile treatment effects. The aim of this work is to estimate the entire interventional distribution. We propose a method called Distributional Instrumental Variable (DIV), which uses generative modelling in a nonlinear IV setting. We establish…

最优因果标注：社会服务个案记录的应用AI 解读

Problem definition: Estimating causal effects of interventions is central to policy and operations, but outcome data are often missing or costly to obtain. LLMs can provide text annotation at scale but may be subject to unknown bias. When ground-truth outcomes require expensive expert labeling or follow-up, budget limits typically allow only a fraction of the data to be labeled. Motivated by collaboration with a nonprofit conducting street outreach in homelessness services,…

异质性治疗效应蒸馏：因果推断中的稳定亚组估计AI 解读

Recent methodological developments have introduced new black-box approaches to better estimate heterogeneous treatment effects; however, these methods fall short of providing interpretable characterizations of the underlying individuals who may be most at risk or benefit most from receiving the treatment, thereby limiting their practical utility. In this work, we introduce causal distillation trees (CDT) to estimate interpretable subgroups. CDT allows researchers to fit any…

结合变分因果推断与细化关系信息预测细胞响应AI 解读

Predicting the responses of a cell under perturbations may bring important benefits to drug discovery and personalized therapeutics. In this work, we propose a novel graph variational Bayesian causal inference framework to predict a cell's gene expressions under counterfactual perturbations (perturbations that this cell did not factually receive), leveraging information representing biological knowledge in the form of gene regulatory networks (GRNs) to aid individualized…

随机试验亚组处理效应的协调估计：外部对照数据的使用AI 解读

Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and eligibility criteria of subsequent confirmatory trials and ultimately influence which subpopulations will receive the treatment after regulatory approval. However, subgroup analyses are often complicated by small sample sizes, which leads to…

局部平均处理效应的随机化置信集合AI 解读

We consider the problem of generating confidence sets in randomized experiments with noncompliance. We show that a refinement of a randomization-based procedure proposed by Imbens and Rosenbaum (2005) has desirable properties. Namely, we show that using a studentized Anderson--Rubin-type statistic as a test statistic yields confidence sets that are finite-sample exact under treatment effect homogeneity, and remain asymptotically valid for the Local Average Treatment Effect…

网络干扰下带聚类的两阶段逐步投放实验设计分析AI 解读

Estimating causal effects under interference is pertinent to many real-world settings. Recent work with low-order potential outcomes models uses a rollout design to obtain unbiased estimators that require no interference network information. However, the required extrapolation can lead to prohibitively high variance. To address this, we propose a two-stage experiment that selects a sub-population in the first stage and restricts treatment rollout to this sub-population in…

利用多个结果变量改进合成控制方法AI 解读

When there are multiple outcome series of interest, Synthetic Control analyses typically proceed by estimating separate weights for each outcome. In this paper, we instead propose estimating a common set of weights across outcomes, by balancing either a vector of all outcomes or an index or average of them. Under a low-rank factor model, we show that these approaches lead to lower bias bounds than separate weights, and that averaging leads to further gains when the number of…

多粒度因果效应的综合机器学习AI 解读

Uncovering causal effects in multiple treatment setting at various levels of granularity provides substantial value to decision makers. Comprehensive machine learning approaches to causal effect estimation allow to use a single causal machine learning approach for estimation and inference of causal mean effects for all levels of granularity. Focusing on selection-on-observables, this paper compares three such approaches, the modified causal forest (mcf), the generalized…

Shapley-PC：受 Shapley 值启发的约束型因果结构学习AI 解读

Causal Structure Learning (CSL), also referred to as causal discovery, amounts to extracting causal relations among variables in data. CSL enables the estimation of causal effects from observational data alone, avoiding the need to perform real life experiments. Constraint-based CSL leverages conditional independence tests to perform causal discovery. We propose Shapley-PC, a novel method to improve constraint-based CSL algorithms by using Shapley values over the possible…

肿瘤试验处理交叉的增强两阶段估计：利用外部数据提高精度AI 解读

Randomized controlled trials (RCTs) in oncology often allow control group participants to crossover to experimental treatments, a practice that, while often ethically necessary, complicates the accurate estimation of long-term treatment effects. When crossover rates are high or sample sizes are limited, commonly used methods for crossover adjustment (such as the rank-preserving structural failure time model, inverse probability of censoring weights, and two-stage estimation…

变分因果推断AI 解读

Estimating an individual's potential outcomes under counterfactual treatments is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, impulse responses, human faces) and covariates are relatively limited. In this case, to construct one's outcome under a counterfactual treatment, it is crucial to leverage individual information contained in its observed factual outcome on top of the…

连续处理匹配观察研究的偏差缓解：卡尺非二分匹配与偏差修正推断AI 解读

In matched observational studies with continuous treatments, individuals with different treatment doses but the same or similar covariate values are paired for causal inference. While inexact covariate matching (i.e., covariate imbalance after matching) is common in practice, previous matched studies with continuous treatments have often overlooked this issue as long as post-matching covariate balance meets certain criteria. Through re-analyzing a matched observational study…

经中介路径传导的因果归因概率AI 解读

We propose a set of causal estimands that we call the "mediated probabilities of causation." These estimands quantify the probabilities that an observed negative outcome was induced via a mediating pathway versus a direct pathway in a stylized setting involving a binary exposure or intervention, a single binary mediator, and a binary outcome. We outline a set of conditions sufficient to identify these effects given observed data, and propose a doubly-robust projection based…

无需平滑参数的多变量根号 n 一致匹配与逆密度加权期望估计AI 解读

Expected values weighted by the inverse of a multivariate density or, equivalently, Lebesgue integrals of regression functions with multivariate regressors occur in various areas of applications, including estimating average treatment effects, nonparametric estimators in random coefficient regression models or deconvolution estimators in Berkson errors-in-variables models. The frequently used nearest-neighbor and matching estimators suffer from bias problems in multiple…

从时间序列因果图的抽象表示识别总效应AI 解读

We study the problem of identifiability of the total effect of an intervention from observational time series in the situation, common in practice, where one only has access to abstractions of the true causal graph. We consider here two abstractions: the extended summary causal graph, which conflates all lagged causal relations but distinguishes between lagged and instantaneous relations, and the summary causal graph which does not give any indication about the lag between…

网络干扰下兼顾估计精度与遗憾的在线实验设计AI 解读

Network interference has attracted significant attention in the field of causal inference, encapsulating various sociological behaviors where the treatment assigned to one individual within a network may affect the outcomes of others, such as their neighbors. A key challenge in this setting is that standard causal inference methods often assume independent treatment effects among individuals, which may not hold in networked environments. To estimate interference-aware causal…

部分观测线性因果模型的参数可识别性AI 解读

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether the edge coefficients can be recovered given the causal structure and partially observed data. Our setting is more general than that of prior research - we allow all variables, including both observed and latent ones, to be flexibly…

高维面板数据模型的稳健估计与推断AI 解读

This paper provides the relevant literature with a complete toolkit for conducting robust estimation and inference about the parameters of interest involved in a high-dimensional panel data framework. Specifically, (1) we allow for non-Gaussian, serially and cross-sectionally correlated and heteroskedastic error processes, (2) we develop an estimation method for high-dimensional long-run covariance matrix using a thresholded estimator, (3) we also allow for the number of…