每日简报

混杂变量缺失时的处理效应评估：双重稳健与传统缺失数据方法比较AI 解读

In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed confounder data are often not available in all data sources and therefore missing on a subset of individuals. Multiple imputation (MI) and inverse-probability weighting (IPW) are go-to analytical methods to handle missing data and are dominant in the biomedical literature. Doubly-robust methods,…

机器学习预测的对偶解释AI 解读

Machine learning predictions are typically interpreted as the sum of contributions of predictors. Yet, each out-of-sample prediction can also be expressed as a linear combination of in-sample values of the predicted variable, with weights corresponding to pairwise proximity scores between current and past economic events. While this dual route leads nowhere in some contexts (e.g., large cross-sectional datasets), it provides sparser interpretations in settings with many…

分位数谱估计的样条自回归方法AI 解读

The quantile spectrum was introduced in Li (2012; 2014) as an alternative tool for spectral analysis of time series. It has the capability of providing a richer view of time series data than that offered by the ordinary spectrum especially for nonlinear dynamics such as stochastic volatility. A novel method, called spline autoregression (SAR), is proposed in this paper for estimating the quantile spectrum as a bivaraite function of frequency and quantile level, under the…

好控制变量为何失效：含协变量的双重差分AI 解读

This paper introduces the two-way common causal covariates (CCC) assumption, which is necessary to get an unbiased estimate of the ATT when using time-varying covariates in existing Difference-in-Differences methods. The two-way CCC assumption implies that the effect of the covariates remain the same between groups and across time periods. This assumption has been implied in previous literature, but has not been explicitly addressed. Through theoretical proofs and a Monte…

放松随机效应正态假设的Meta分析模型：系统综述与模拟AI 解读

Random effects meta-analysis is widely used for synthesizing studies under the assumption that underlying effects come from a normal distribution. However, under certain conditions the use of alternative distributions might be more appropriate. We conducted a systematic review to identify articles introducing alternative meta-analysis models assuming non-normal between-study distributions. We identified 27 eligible articles suggesting 24 alternative meta-analysis models…

替代指标在个体因果效应共形推断中的作用AI 解读

Learning the Individual Treatment Effect (ITE) is essential for personalized decision-making, yet causal inference has traditionally focused on aggregated treatment effects. While integrating conformal prediction with causal inference can provide valid uncertainty quantification for ITEs, the resulting prediction intervals are often excessively wide, limiting their practical utility. To address this limitation, we introduce \underline{S}urrogate-assisted…

仅利用目标总体汇总数据的可迁移性分析：目标聚合数据调整法AI 解读

Transportability analysis is a causal inference framework used to evaluate the external validity of randomized clinical trials (RCTs) or observational studies. Most existing transportability analysis methods require individual patient-level data (IPD) for both the source and the target population, narrowing its applicability when only target aggregate-level data (AgD) is available. Besides, accounting for censoring is essential to reduce bias in longitudinal data, yet…

熵最优（自）传输问题：正则化递减的极限分布及其在得分函数估计中的应用AI 解读

We study the statistical properties of the entropic optimal (self) transport problem for smooth probability measures. We provide an accurate description of the limit distribution for entropic (self-)potentials and plans as the regularization parameter shrinks with the sample size; this regime is largely unexplored in the prior statistical literature, where $ε$ is typically held fixed. Additionally, we show that a rescaling of the barycentric projection of the empirical…

生存结局下异质性处理效应的变量重要性度量AI 解读

Treatment effect heterogeneity plays an important role in many areas of causal inference and within recent years, estimation of the conditional average treatment effect (CATE) has received much attention in the statistical community. While accurate estimation of the CATE-function through flexible machine learning procedures provides a tool for prediction of the individual treatment effect, it does not provide further insight into the driving features of potential treatment…

目标估计量框架与因果推断：相互补充的范式AI 解读

The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical trials. However, it is unclear how the new framework relates to causal inference, as both approaches appear to define what is being estimated and have a quantity labelled an estimand. Using illustrative examples, we show that both approaches can be used to define a population-based summary of an…

估计纵向替代结局治疗效应的半参数联合模型：慢性肾病试验应用AI 解读

In clinical trials where long follow-up is required to measure the primary outcome of interest, there is substantial interest in using an accepted surrogate outcome that can be measured earlier in time or with less cost to estimate a treatment effect. For example, in clinical trials of chronic kidney disease (CKD), the effect of a treatment is often demonstrated on a surrogate outcome, the longitudinal trajectory of glomerular filtration rate (GFR). However, estimating the…

以无模型方法评估删失中间结局对总生存期的替代作用AI 解读

Clinical trials or studies oftentimes require long-term and/or costly follow-up of participants to evaluate a novel treatment/drug/vaccine. There has been increasing interest in the past few decades in using short-term surrogate outcomes as a replacement of the primary outcome i.e., in using the surrogate outcome, which can potentially be observed sooner, to make inference about the treatment effect on the long-term primary outcome. Very few of the available statistical…

贝叶斯因果发现的元学习方法AI 解读

Discovering a unique causal structure is difficult due to both inherent identifiability issues, and the consequences of finite data. As such, uncertainty over causal structures, such as those obtained from a Bayesian posterior, are often necessary for downstream tasks. Finding an accurate approximation to this posterior is challenging, due to the large number of possible causal graphs, as well as the difficulty in the subproblem of finding posteriors over the functional…

利用工具增强的大语言模型智能体开展多模态因果发现AI 解读

Causal discovery is an imperative foundation for decision-making across domains, such as smart health, AI for drug discovery and AIOps. Traditional statistical causal discovery methods, while well-established, predominantly rely on observational data and often overlook the semantic cues inherent in cause-and-effect relationships. The advent of Large Language Models (LLMs) has ushered in an affordable way of leveraging the semantic cues for knowledge-driven causal discovery,…

存在内生性时的高维切片逆回归AI 解读

Sliced inverse regression (SIR) is a popular sufficient dimension reduction method that identifies a few linear transformations of the covariates without losing regression information with the response. In high-dimensional settings, SIR can be combined with sparsity penalties to achieve sufficient dimension reduction and variable selection simultaneously. Nevertheless, both classical and sparse estimators assume the covariates are exogenous. However, endogeneity can arise in…

通过高效非凸优化学习因果不变性AI 解读

Identifying the causal relationship among variables from observational data is an important yet challenging task. This work focuses on identifying the direct causes of an outcome and estimating their magnitude, i.e., learning the causal outcome model. Data from multiple environments provide valuable opportunities to uncover causality by exploiting the invariance principle that the causal outcome model holds across heterogeneous environments. Based on the invariance…

结合 BART 与主分层估计避孕使用对就业的影响：尼日利亚与塞内加尔AI 解读

There is interest in learning about the causal effects of modern contraceptive use on empowerment outcomes. Data on this question often come from family planning (FP) programs that increase access to FP and facilitate contraceptive use among some women, rather than directly assigning use. Women whose contraceptive behavior changes because of these programs ("compliers") may differ from target populations in ways that alter the consequences of contraceptive use for…

计数反向响应者：实验设计模型提供超越平均效应的证据AI 解读

Using only a binary intervention and outcome and the design of the randomization within an experiment, we construct a design-based likelihood of the joint distribution of potential outcomes in the sample -- the numbers of always takers, compliers, defiers, and never takers. We develop a visualization to show that samples with defiers can sometimes generate the data in more ways than samples without, yielding a higher likelihood. This likelihood can vary within the Frechet…

Ramsey 式空间交互函数线性检验AI 解读

We propose a computationally straightforward test for the linearity of a spatial interaction function. Such functions arise commonly, either as practitioner imposed specifications or due to optimizing behaviour by agents. Our conditional heteroskedasticity robust test is nonparametric, but based on the Lagrange Multiplier principle and reminiscent of the Ramsey RESET approach. This entails estimation only under the null hypothesis, which yields an easy to estimate linear…

时空因果推断中的异质性处理效应估计AI 解读

Scholars from diverse fields increasingly rely on high-frequency spatio-temporal data. Yet, causal inference with these data remains challenging due to spatial spillover and temporal carryover effects. We develop methods to estimate heterogeneous treatment effects by allowing for arbitrary spatial and temporal causal dependencies. We focus on common settings where the treatment and outcomes are time-varying spatial point patterns and where moderators are either spatial or…

匹配型平均处理效应估计量的高斯与 Bootstrap 近似AI 解读

We establish Gaussian approximation bounds for covariate and rank-matching-based Average Treatment Effect (ATE) estimators. By analyzing these estimators through the lens of stabilization theory, we employ the Malliavin-Stein method to derive our results. Our bounds precisely quantify the impact of key problem parameters, including the number of matches and treatment balance, on the accuracy of the Gaussian approximation. Additionally, we develop multiplier bootstrap…

短面板固定效应 Logit 模型中平均因果效应的识别与估计AI 解读

This paper studies identification and estimation of average causal effects, such as average marginal or treatment effects, in fixed effects logit models with short panels. Relating the identified set of these effects to an extremal moment problem, we first show how to obtain sharp bounds on such effects simply, without any optimization. We also consider even simpler outer bounds, which, contrary to the sharp bounds, do not require any first-step nonparametric estimators. We…

结合模型平均与匹配估计异方差下的条件平均处理效应AI 解读

We propose a model averaging approach, combined with a partition and matching method to estimate the conditional average treatment effects under heteroskedastic error settings. The proposed approach has asymptotic optimality and consistency of weights and estimator. Numerical studies show that our method has good finite-sample performances.

GLACIAL：面向纵向影像研究的格兰杰与学习式因果分析AI 解读

The Granger framework is useful for discovering causal relations in time-varying signals. However, most Granger causality (GC) methods are developed for densely sampled timeseries data. A substantially different setting, particularly common in medical imaging, is the longitudinal study design, where multiple subjects are followed and sparsely observed over time. Longitudinal studies commonly track several biomarkers, which are likely governed by nonlinear dynamics that might…