每日简报

基于方差加权投影的高维二元协变量 Logistic 回归有效贝叶斯推断AI 解读

We address the challenge of conducting inference for a categorical treatment effect related to a binary outcome variable while taking into account high-dimensional baseline covariates. The conventional technique used to establish orthogonality for the treatment effect from nuisance variables in continuous cases is inapplicable in the context of binary treatment. To overcome this obstacle, an orthogonal score tailored specifically to this scenario is formulated which is based…

高维中介分析的贝叶斯变量选择：流行病学代谢组数据应用AI 解读

In epidemiological research, causal models incorporating potential mediators along a pathway are crucial for understanding how exposures influence health outcomes. This work is motivated by integrated epidemiological and blood biomarker studies, investigating the relationship between long-term adherence to a Mediterranean diet and cardiometabolic health, with plasma metabolomes as potential mediators. Analyzing causal mediation in such high-dimensional omics data presents…

正则化多大语言模型协作辅助基于评分的因果发现AI 解读

As the significance of understanding the cause-and-effect relationships among variables increases in the development of modern systems and algorithms, learning causality from observational data has become a preferred and efficient approach over conducting randomized control trials. However, purely observational data could be insufficient to reconstruct the true causal graph. Consequently, many researchers tried to utilise some form of prior knowledge to improve causal…

纵向中介与事件时间结局的贝叶斯半参数因果中介分析AI 解读

Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors. However, when analyzing data from a cohort study, such analyses are complicated by the longitudinal structure of the risk factors and the presence of time-varying confounders. Leveraging data from the Atherosclerosis Risk in Communities…

结局非随机缺失下的双重差分设计AI 解读

This paper addresses one of the most prevalent problems encountered by political scientists working with difference-in-differences (DID) design: missingness in panel data. A common practice for handling missing data, known as complete case analysis, is to drop cases with any missing values over time. A more principled approach involves using nonparametric bounds on causal effects or applying inverse probability weighting based on baseline covariates. Yet, these methods are…

用伪值简化事件发生时间结局的因果中介分析AI 解读

Mediation analysis for survival outcomes is challenging. Most existing methods quantify the treatment effect using the hazard ratio (HR) and attempt to decompose the HR into the direct effect of treatment plus an indirect, or mediated, effect. However, the HR is not expressible as an expectation, which complicates this decomposition, both in terms of estimation and interpretation. Here, we present an alternative approach which leverages pseudo-values to simplify estimation…

说服研究中的二元工具变量模型：刻画服从者的说服类型AI 解读

In an empirical study of persuasion, researchers often use a binary instrument to encourage individuals to consume information and take some action. We show that, with a binary Imbens-Angrist instrumental variable model and the monotone treatment response assumption, it is possible to identify the joint distribution of potential outcomes among compliers. This is necessary to identify the percentage of mobilised voters and their statistical characteristic defined by the…

摆脱截断与删失限制的学习框架及其处理效应应用AI 解读

Time-to-event outcomes are often subject to left truncation and right censoring. While many survival analysis methods have been developed to handle truncation and censoring, majority of the past works require strong independence assumptions. We relax these stringent assumptions through leveraging covariate information together with orthogonal learning, and develop a liberating framework from left truncation and right censoring so that desirable properties like double…

环境暴露对社会流动的影响：主分层的贝叶斯半参数方法AI 解读

Understanding the causal effects of air pollution exposures on social mobility is attracting increasing attention. At the same time, education is widely recognized as a key driver of social mobility. However, the causal pathways linking fine particulate matter (PM2.5) exposure, educational attainment, and social mobility remain largely unexplored. To address this, we adopt the principal stratification approach, which rigorously defines causal effects when a post-treatment…

局部化共形多分位数回归AI 解读

Standard conformal prediction methods guarantee marginal coverage but often produce inefficient intervals that fail to adapt to local heteroscedasticity, while recent localized approaches often struggle to maintain validity across distinct subpopulations with varying noise profiles. To address these challenges, we introduce Localized Conformal Multi-Quantile Regression (LCMQR), a novel framework that synergizes multi-quantile information with kernel-based localization to…

信息性与非信息性缺失未知混合下的因果效应界限AI 解读

In experimental and observational data settings, researchers often have limited knowledge of the reasons for missing outcomes. To address this uncertainty, we propose bounds on causal effects for missing outcomes, accommodating the scenario where missingness is an unobserved mixture of informative and non-informative components. Within this mixed missingness framework, we explore several assumptions to derive bounds on causal effects, including bounds expressed as a function…

观察研究中效应修饰的子群感知评分方法AI 解读

Effect modification means the size of a treatment effect varies with an observed covariate. Generally speaking, a larger treatment effect with more stable error terms is less sensitive to bias. Thus, we might be able to conclude that a study is less sensitive to unmeasured bias by using these subgroups experiencing larger treatment effects. Lee et al. (2018) proposed the submax method that leverages the joint distribution of test statistics from subgroups to draw a firmer…

线性模型中的最优检验及其因果推断含义AI 解读

Despite its widespread use in practice, multiple regression suffers from two important limitations due to ignoring the structure between predictors. First, reported coefficients are, in fact, direct effects in a causal context. These are often less meaningful than total effects when accounting for a factor's contribution, however, estimating the latter typically requires a causal diagram to be specified among predictors. The second limitation is multicollinearity, which…

近似邻域干扰下的辅助变量调整AI 解读

Randomized experiments are the gold standard for causal inference. However, traditional assumptions, such as the Stable Unit Treatment Value Assumption (SUTVA), often fail in real-world settings where interference between units is present. Network interference, in particular, has garnered significant attention. Structural models, like the linear-in-means model, are commonly used to describe interference; but they rely on the correct specification of the model, which can be…

存在潜变量时非参数因果效应估计的局部协变量选择AI 解读

Estimating causal effects from nonexperimental data is a fundamental problem in many fields of science. A key component of this task is selecting an appropriate set of covariates for confounding adjustment to avoid bias. Most existing methods for covariate selection often assume the absence of latent variables and rely on learning the global network structure among variables. However, identifying the global structure can be unnecessary and inefficient, especially when our…

如何选择因果推断的协变量平衡方法：模拟研究的实践启示AI 解读

Background: Inverse probability of treatment weighting (IPTW) is used for confounding adjustment in observational studies. Newer weighting methods include energy balancing (EB), kernel optimal matching (KOM), and tailored-loss covariate balancing propensity scores (TLF), but practical guidance remains limited. We evaluate their performance when implemented according to published recommendations. Methods: We conducted Monte Carlo simulations across 36 scenarios varying sample…

连续纵向中间变量下主层分层的敏感性分析：队列阶梯楔形试验应用AI 解读

Causal inference in the presence of intermediate variables is a challenging problem in many applications. Principal stratification (PS) provides a framework to estimate principal causal effects (PCE) in such settings. However, existing PS methods primarily focus on settings with binary intermediate variables. We propose a novel approach to estimate PCE with continuous intermediate variables in the context of stepped wedge cluster randomized trials (SW-CRTs). Our method…

固定簇内重复抽取不同个体以提高纵向估计精度：DISC 设计AI 解读

Background: Longitudinal studies often involve repeated cluster sampling of a population at multiple time points, such as in difference-in-differences (DID) studies. Although cohort designs typically lead to more efficient estimators relative to repeated cross-sectional (RCS) designs, they are often impractical. Methods: We describe the DISC (Different Individuals, Same Clusters) design, a sampling scheme that improves the precision of estimators in these settings. The DISC…

环境不变线性最小二乘AI 解读

This paper considers a multi-environment linear regression model in which data from multiple experimental settings are collected. The joint distribution of the response variable and covariates may vary across different environments, yet the conditional expectations of $y$ given the unknown set of important variables are invariant. Such a statistical model is related to the problem of endogeneity, causal inference, and transfer learning. The motivation behind it is…

二元随机实验中符合因果结构的先验AI 解读

We introduce the BREASE framework for the Bayesian analysis of randomized controlled trials with a binary treatment and a binary outcome. Approaching the problem from a causal inference perspective, we propose parameterizing the likelihood in terms of the baselinerisk, efficacy, and adverse side effects of the treatment, along with a flexible, yet intuitive and tractable jointly independent beta prior distribution on these parameters, which we show to be a generalization of…

含协变量的局部平均处理效应推断AI 解读

In theory, two-stage least squares (TSLS) identifies a weighted average of covariate-specific local average treatment effects (LATEs) from a saturated specification, without making parametric assumptions on how available covariates enter the model. In practice, TSLS is severely biased as saturation leads to a large number of control dummies and an equally large number of, arguably weak, instruments. This paper derives asymptotically valid tests and confidence intervals for…

形状约束函数型时间序列的状态空间建模AI 解读

Functional time series data frequently appears in econometric analyses, where the functions of interest are subject to some shape constraints, including monotonicity and convexity, as typical of the estimation of the Lorenz curve. This paper proposes a state-space model for time-varying functions to extract trends and serial dependence from functional time series while imposing the shape constraints on the estimated functions. The function of interest is modeled by a convex…