Assessing mediation in cross-sectional stepped wedge cluster randomized trials
横截面阶梯楔形整群随机试验中的中介分析
Mediation analysis has been comprehensively studied for independent data but relatively little work has been done for correlated data, especially for the increasingly adopted stepped wedge cluster randomized trials (SW-CRTs). Motivated by challenges in underlying the effect mechanisms in pragmatic and implementation science clinical trials, we develop new methods for mediation analysis in SW-CRTs. Specifically, based on a linear and generalized linear mixed models, we…