每日简报

数据驱动的切换实验：理论权衡与经验贝叶斯设计AI 解读

We study the design and analysis of switchback experiments conducted on a single aggregate unit. The design problem is to partition the continuous time space into intervals and switch treatments between intervals, in order to minimize the estimation error of the treatment effect. We show that the estimation error depends on four factors: carryover effects, periodicity, serially correlated outcomes, and impacts from simultaneous experiments. We derive a rigorous bias-variance…

不同非比例风险情形下处理效应评价的统计考量AI 解读

We conducted a systematic comparison of statistical methods used for the analysis of time-to-event outcomes under various proportional and nonproportional hazard (NPH) scenarios. Our study used data from recently published oncology trials to compare the Log-rank test, still by far the most widely used option, against some available alternatives, including the MaxCombo test, the Restricted Mean Survival Time Difference (dRMST) test, the Generalized Gamma Model (GGM) and the…

结合弱工具变量与观测数据估计异质性处理效应AI 解读

Accurately predicting conditional average treatment effects (CATEs) is crucial in personalized medicine and digital platform analytics. Since the treatments of interest often cannot be directly randomized, observational data is leveraged to learn CATEs, but this approach can incur significant bias from unobserved confounding. One strategy to overcome these limitations is to leverage instrumental variables (IVs) as latent quasi-experiments, such as randomized intent-to-treat…

通过协变量选择优化平衡的自适应随机化方法AI 解读

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline covariates is large. It is therefore essential to identify the influential factors associated with the outcome and ensure balance among these critical covariates. In this article, we propose a novel adaptive randomization approach that…

检测阴性设计的敏感性分析AI 解读

The test-negative design has become popular for evaluating the effectiveness of post-licensure vaccines using observational data. In addition to its logistical convenience on data collection, the design is also believed to control for the differential health-care-seeking behavior between vaccinated and unvaccinated individuals, an important while often unmeasured confounder between the vaccination and infection. Hence, the design has been employed routinely to monitor…

单人试验的因果推断AI 解读

The aim of personalized medicine is to tailor treatment decisions to individuals' characteristics. N-of-1 trials are within-person crossover trials that hold the promise of targeting individual-specific effects. While the idea behind N-of-1 trials might seem simple, analyzing and interpreting N-of-1 trials is not straightforward. Here we ground N-of-1 trials in a formal causal inference framework and formalize intuitive claims from the N-of-1 trials literature. We focus on…

基于最优传输的多元随机占优及模型基准比较AI 解读

Stochastic dominance is an important concept in probability theory, econometrics and social choice theory for robustly modeling agents' preferences between random outcomes. While many works have been dedicated to the univariate case, little has been done in the multivariate scenario, wherein an agent has to decide between different multivariate outcomes. By exploiting a characterization of multivariate first stochastic dominance in terms of couplings, we introduce a…

带阈值识别的生物标志物引导自适应富集生存试验设计AI 解读

Biomarker-guided designs are increasingly used to evaluate personalized treatments based on patients' biomarker status in Phase II and III clinical trials. With adaptive enrichment, these designs can improve the efficiency of evaluating the treatment effect in biomarker-positive patients by increasing their proportion in the randomized trial. While time-to-event outcomes are often used as the primary endpoint to measure treatment effects for a new therapy in severe diseases…

Harold Zuercher 的偏好具有时间可分性吗？AI 解读

This paper proposes an empirical model of dynamic discrete choice to allow for non-separable time preferences, generalizing the well-known Rust (1987) model. Under weak conditions, we show the existence of value functions and hence well-defined optimal choices. We construct a contraction mapping of the value function and propose an estimation method similar to Rust's nested fixed point algorithm. Finally, we apply the framework to the bus engine replacement data. We improve…

通过稳健估计处理暴露缺失的因果推断AI 解读

How to deal with missing data in observational studies is a common concern for causal inference. When the covariates are missing at random (MAR), multiple approaches have been provided to help solve the issue. However, if the exposure is MAR, few approaches are available and careful adjustments on both missingness and confounding issues are required to ensure a consistent estimate of the true causal effect on the response. In this article, a new inverse probability weighting…

法官工具变量设计中的多维聚类AI 解读

Estimates in judge designs run the risk of being biased due to the many judge identities that are implicitly or explicitly used as instrumental variables. The usual method to analyse judge designs, via a leave-out mean instrument, eliminates this many instrument bias only in case the data are clustered in at most one dimension. What is left out in the mean defines this clustering dimension. How most judge designs cluster their standard errors, however, implies that there are…

存在测量误差时的协变量平衡AI 解读

In recent years, there is a growing body of causal inference literature focusing on covariate balancing methods. These methods eliminate observed confounding by equalizing covariate moments between the treated and control groups. The validity of covariate balancing relies on an implicit assumption that all covariates are accurately measured, which is frequently violated in observational studies. Nevertheless, the impact of measurement error on covariate balancing is unclear,…

无法直接分配处理时的自适应实验AI 解读

This paper introduces the \emph{confounded pure exploration transductive linear bandit} (\texttt{CPET-LB}) problem. As a motivating example, often online services cannot directly assign users to specific control or treatment experiences either for business or practical reasons. In these settings, naively comparing treatment and control groups that may result from self-selection can lead to biased estimates of underlying treatment effects. Instead, online services can employ…

连接多个潜在世界：因果部分识别的多边际最优传输方法AI 解读

Under the prevalent potential outcome model in causal inference, each unit is associated with multiple potential outcomes but at most one of which is observed, leading to many causal quantities being only partially identified. The inherent missing data issue echoes the multi-marginal optimal transport (MOT) problem, where marginal distributions are known, but how the marginals couple to form the joint distribution is unavailable. In this paper, we cast the causal partial…

函数型因果发现的诊断工具AI 解读

Causal discovery methods aim to determine the causal direction between variables using observational data. Functional causal discovery methods, such as those based on the Linear Non-Gaussian Acyclic Model (LiNGAM), rely on structural and distributional assumptions to infer the causal direction. However, approaches for assessing causal discovery methods' performance as a function of sample size or the impact of assumption violations, inevitable in real-world scenarios, are…

混合有向无环图中的干预式因果发现AI 解读

Causal interactions among a group of variables are often modeled by a single causal graph. In some domains, however, these interactions are best described by multiple co-existing causal graphs, e.g., in dynamical systems or genomics. This paper addresses the hitherto unknown role of interventions in learning causal interactions among variables governed by a mixture of causal systems, each modeled by one directed acyclic graph (DAG). Causal discovery from mixtures is…

控制基于预测集的决策支持系统中的反事实伤害AI 解读

Decision support systems based on prediction sets help humans solve multiclass classification tasks by narrowing down the set of potential label values to a subset of them, namely a prediction set, and asking them to always predict label values from the prediction sets. While this type of systems have been proven to be effective at improving the average accuracy of the predictions made by humans, by restricting human agency, they may cause harm$\unicode{x2014}$a human who…

通过随机位移干预与交叉验证靶向学习自适应识别效应修饰因素AI 解读

In epidemiology, identifying subpopulations that are particularly vulnerable to exposures and those who may benefit differently from exposure-reducing interventions is essential. Factors such as age, gender-specific vulnerabilities, and physiological states such as pregnancy are critical for policymakers when setting regulatory guidelines. However, current semi-parametric methods for estimating heterogeneous treatment effects are often limited to binary exposures and can…

利用因果图分区在高维结构化假设空间中发现因果关系AI 解读

The aim in many sciences is to understand the mechanisms that underlie the observed distribution of variables, starting from a set of initial hypotheses. Causal discovery allows us to infer mechanisms as sets of cause and effect relationships in a generalized way -- without necessarily tailoring to a specific domain. Causal discovery algorithms search over a structured hypothesis space, defined by the set of directed acyclic graphs, to find the graph that best explains the…

嵌入网络自回归：时间序列分析与因果同伴效应推断AI 解读

We propose an Embedding Network Autoregressive Model for multivariate networked longitudinal data. We assume the network is generated from a latent variable model, and these unobserved variables are included in a structural peer effect model or a time series network autoregressive model as additive effects. This approach takes a unified view of two related yet fundamentally different problems: (1) modeling and predicting multivariate networked time series data and (2) causal…

结局均值函数一般半参数约束下的有效估计与数据融合AI 解读

We provide a novel characterization of semiparametric efficiency in a generic supervised learning setting where the outcome mean function -- defined as the conditional expectation of the outcome of interest given the other observed variables -- is restricted to lie in some known semiparametric function class. The primary motivation is causal inference where a researcher running a randomized controlled trial often has access to an auxiliary observational dataset that is…

协变量自适应随机化与不完全依从下处理效应的识别和推断AI 解读

Randomized controlled trials (RCTs) frequently utilize covariate-adaptive randomization (CAR) (e.g., stratified block randomization) and commonly suffer from imperfect compliance. This paper studies the identification and inference for the average treatment effect (ATE) and the average treatment effect on the treated (ATT) in such RCTs with a binary treatment. We first develop characterizations of the identified sets for both estimands. Since data are generally not i.i.d.…

死亡截断与非随机缺失结局下的因果推断AI 解读

In clinical trials, principal stratification analysis is commonly employed to address the issue of truncation by death, where a subject dies before the outcome can be measured. However, in practice, many survivor outcomes may remain uncollected or be missing not at random, posing a challenge to standard principal stratification analyses. In this paper, we explore the identification, estimation, and bounds of the average treatment effect within a subpopulation of individuals…

双向聚类下的刀切法推断AI 解读

For linear regression models with cross-section or panel data, it is natural to assume that the disturbances are clustered in two dimensions. However, the finite-sample properties of two-way cluster-robust tests and confidence intervals are often poor. We discuss several ways to improve inference with two-way clustering. Two of these are existing methods for avoiding, or at least ameliorating, the problem of undefined standard errors when a cluster-robust variance matrix…