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Weighting methods for truncation by death in cluster-randomized trials

整群随机试验中处理死亡截断的加权方法

Patient-centered outcomes, such as quality of life and length of hospital stay, are the focus in a wide array of clinical studies. However, participants in randomized trials for elderly or critically and severely ill patient populations may have truncated or undefined non-mortality outcomes if they do not survive through the measurement time point. To address truncation by death, the survivor average causal effect (SACE) has been proposed as a causally interpretable subgroup…

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Covariate Ordered Systematic Sampling as an Improvement to Randomized Controlled Trials

协变量排序系统抽样:改进随机对照试验的分配方法

The Randomized Controlled Trial (RCT) or A/B testing is considered the gold standard method for estimating causal effects. Fisher famously advocated randomly allocating experiment units into treatment and control groups to preclude systematic biases. We propose a variant of systematic sampling called Covariate Ordered Systematic Sampling (COSS). In COSS, we order experimental units using a pre-experiment covariate and allocate them alternately into treatment and control…

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Multiply Robust Difference-in-Differences Estimation of Causal Effect Curves for Continuous Exposures

连续暴露因果效应曲线的多重稳健双重差分估计

Researchers commonly use difference-in-differences (DiD) designs to evaluate public policy interventions. While methods exist for estimating effects in the context of binary interventions, policies often result in varied exposures across regions implementing the policy. Yet, existing approaches for incorporating continuous exposures face substantial limitations in addressing confounding variables associated with intervention status, exposure levels, and outcome trends. These…

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Adjusting for bias due to measurement error in functional quantile regression models with error-prone functional and scalar covariates

函数型分位数回归中函数型与标量协变量测量误差的偏误校正

Wearable devices enable the continuous monitoring of physical activity (PA) but generate complex functional data with poorly characterized errors. Most work on functional data views the data as smooth, latent curves obtained at discrete time intervals with some random noise with mean zero and constant variance. Viewing this noise as homoscedastic and independent ignores potential serial correlations. Our preliminary studies indicate that failing to account for these serial…

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A Combinatorial Central Limit Theorem for Stratified Randomization

分层随机化的组合中心极限定理

This paper establishes a combinatorial central limit theorem for stratified randomization, which holds under a Lindeberg-type condition. The theorem allows for an arbitrary number or sizes of strata, with the sole requirement being that each stratum contains at least two units. This flexibility accommodates both a growing number of large and small strata simultaneously, while imposing minimal conditions. We then apply this result to derive the asymptotic distributions of two…

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A General Identification Algorithm For Data Fusion Problems Under Systematic Selection

系统性选择下数据融合问题的一般识别算法

Causal inference is made challenging by confounding, selection bias, and other complications. A common approach to addressing these difficulties is the inclusion of auxiliary data on the superpopulation of interest. Such data may measure a different set of variables, or be obtained under different experimental conditions than the primary dataset. Analysis based on multiple datasets must carefully account for similarities between datasets, while appropriately accounting for…

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Safe subspace screening for the adaptive nuclear norm regularized trace regression

自适应核范数正则化迹回归的安全子空间筛选

Matrix form data sets arise in many areas, so there are lots of works about the matrix regression models. One special model of these models is the adaptive nuclear norm regularized trace regression, which has been proven have good statistical performances. In order to accelerate the computation of this model, we consider the technique called screening rule. According to matrix decomposition and optimal condition of the model, we develop a safe subspace screening rule that…

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Temporal Aggregation for the Synthetic Control Method

合成控制法中的时间聚合

The synthetic control method (SCM) is a popular approach for estimating the impact of a treatment on a single unit with panel data. Two challenges arise with higher frequency data (e.g., monthly versus yearly): (1) achieving excellent pre-treatment fit is typically more challenging; and (2) overfitting to noise is more likely. Aggregating data over time can mitigate these problems but can also destroy important signal. In this paper, we bound the bias for SCM with…

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Extreme quantile regression with deep learning

结合深度学习的极端分位数回归

Estimation of extreme conditional quantiles is often required for risk assessment of natural hazards in climate and geo-environmental sciences and for quantitative risk management in statistical finance, econometrics, and actuarial sciences. Interest often lies in extrapolating to quantile levels that exceed any past observations. Therefore, it is crucial to use a statistical framework that is well-adapted and especially designed for this purpose, and here extreme-value…

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Towards Characterizing Domain Counterfactuals For Invertible Latent Causal Models

可逆潜在因果模型中领域反事实的刻画

Answering counterfactual queries has important applications such as explainability, robustness, and fairness but is challenging when the causal variables are unobserved and the observations are non-linear mixtures of these latent variables, such as pixels in images. One approach is to recover the latent Structural Causal Model (SCM), which may be infeasible in practice due to requiring strong assumptions, e.g., linearity of the causal mechanisms or perfect atomic…

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Fast Variational Inference for Bayesian Factor Analysis in Single and Multi-Study Settings

单研究与多研究贝叶斯因子分析的快速变分推断

Factors models are routinely used to analyze high-dimensional data in both single-study and multi-study settings. Bayesian inference for such models relies on Markov Chain Monte Carlo (MCMC) methods which scale poorly as the number of studies, observations, or measured variables increase. To address this issue, we propose variational inference algorithms to approximate the posterior distribution of Bayesian latent factor models using the multiplicative gamma process…

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The boosted HP filter is more general than you might think

增强型 HP 滤波器的适用范围比想象中更广

The global financial crisis and Covid recession have renewed discussion concerning trend-cycle discovery in macroeconomic data, and boosting has recently upgraded the popular HP filter to a modern machine learning device suited to data-rich and rapid computational environments. This paper extends boosting's trend determination capability to higher order integrated processes and time series with roots that are local to unity. The theory is established by understanding the…

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Interpretable discriminant analysis for functional data supported on random nonlinear domains with an application to Alzheimer's disease

面向随机非线性域函数数据的可解释判别分析及其在阿尔茨海默病中的应用

We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their cortical surface geometry and associated cortical thickness map. The proposed model is based upon a reformulation of the classification problem as a regularized multivariate functional linear regression model. This allows us to adopt a direct…

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A Latent Factor Model for High-Dimensional Binary Data

高维二元数据的潜在因子模型

In this study, we develop a latent factor model for analysing high-dimensional binary data. Specifically, a standard probit model is used to describe the regression relationship between the observed binary data and the continuous latent variables. Our method assumes that the dependency structure of the observed binary data can be fully captured by the continuous latent factors. To estimate the model, a moment-based estimation method is developed. The proposed method is able…

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A Balanced Statistical Boosting Approach for GAMLSS via New Step Lengths

基于新步长的GAMLSS平衡统计提升方法

Component-wise gradient boosting algorithms are popular for their intrinsic variable selection and implicit regularization, which can be especially beneficial for very flexible model classes. When estimating generalized additive models for location, scale and shape (GAMLSS) by means of a component-wise gradient boosting algorithm, an important part of the estimation procedure is to determine the relative complexity of the submodels corresponding to the different distribution…

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Inference of treatment effect and its regional modifiers using restricted mean survival time in multi-regional clinical trials

多区域临床试验中基于限制平均生存时间的处理效应及区域修饰因素推断

Multi-regional clinical trials (MRCTs) play an increasingly crucial role in global pharmaceutical development by expediting data gathering and regulatory approval across diverse patient populations. However, differences in recruitment practices and regional demographics often lead to variations in study participant characteristics, potentially biasing treatment effect estimates and undermining treatment effect consistency assessment across regions. To address this challenge,…

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CAVIAR: Categorical-Variable Embeddings for Accurate and Robust Inference

CAVIAR:用于准确与稳健推断的类别变量嵌入

Social science research often hinges on the relationship between categorical variables and outcomes. We introduce CAVIAR, a novel method for embedding categorical variables that assume values in a high-dimensional ambient space but are sampled from an underlying manifold. Our theoretical and numerical analyses outline challenges posed by such categorical variables in causal inference. Specifically, dynamically varying and sparse levels can lead to violations of the Donsker…

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An Overview of Diffusion Models: Applications, Guided Generation, Statistical Rates and Optimization

扩散模型概览:应用、引导生成、统计速率与优化

Diffusion models, a powerful and universal generative AI technology, have achieved tremendous success in computer vision, audio, reinforcement learning, and computational biology. In these applications, diffusion models provide flexible high-dimensional data modeling, and act as a sampler for generating new samples under active guidance towards task-desired properties. Despite the significant empirical success, theory of diffusion models is very limited, potentially slowing…

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Joint mixed-effects models for causal inference in clustered network-based observational studies

聚类网络观察研究中用于因果推断的联合混合效应模型

Causal inference on populations embedded in social networks poses technical challenges, since the typical no interference assumption frequently does not hold. Existing methods developed in the context of network interference rely upon the assumption of no unmeasured confounding. However, when faced with multilevel network data, there may be a latent factor influencing both the exposure and the outcome at the cluster level. We propose a Bayesian inference approach that…

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Debiasing Welch's Method for Spectral Density Estimation

Welch 谱密度估计方法的去偏

Welch's method provides an estimator of the power spectral density that is statistically consistent. This is achieved by averaging over periodograms calculated from overlapping segments of a time series. For a finite length time series, while the variance of the estimator decreases as the number of segments increase, the magnitude of the estimator's bias increases: a bias-variance trade-off ensues when setting the segment number. We address this issue by providing a novel…

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Local Causal Discovery for Estimating Causal Effects

用于估计因果效应的局部因果发现

Even when the causal graph underlying our data is unknown, we can use observational data to narrow down the possible values that an average treatment effect (ATE) can take by (1) identifying the graph up to a Markov equivalence class; and (2) estimating that ATE for each graph in the class. While the PC algorithm can identify this class under strong faithfulness assumptions, it can be computationally prohibitive. Fortunately, only the local graph structure around the…

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A New Statistic for Testing Covariance Equality in High-Dimensional Gaussian Low-Rank Models

高维高斯低秩模型中检验协方差相等的新统计量

In this paper, we consider the problem of testing equality of the covariance matrices of L complex Gaussian multivariate time series of dimension $M$ . We study the special case where each of the L covariance matrices is modeled as a rank K perturbation of the identity matrix, corresponding to a signal plus noise model. A new test statistic based on the estimates of the eigenvalues of the different covariance matrices is proposed. In particular, we show that this statistic…

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Permutation Testing for Monotone Trend

单调趋势的置换检验

In this paper, we consider the fundamental problem of testing for monotone trend in a time series. While the term "trend" is commonly used and has an intuitive meaning, it is first crucial to specify its exact meaning in a hypothesis testing context. A commonly used well-known test is the Mann-Kendall test, which we show does not offer Type 1 error control even in large samples. On the other hand, by an appropriate studentization of the Mann-Kendall statistic, we construct…

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Partition-Insensitive Parallel ADMM Algorithm for High-dimensional Linear Models

面向高维线性模型的分区不敏感并行 ADMM 算法

The parallel alternating direction method of multipliers (ADMM) algorithms have gained popularity in statistics and machine learning due to their efficient handling of large sample data problems. However, the parallel structure of these algorithms, based on the consensus problem, can lead to an excessive number of auxiliary variables when applied to highdimensional data, resulting in large computational burden. In this paper, we propose a partition-insensitive parallel…

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