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A tutorial on panel data analysis using partially observed Markov processes via the R package panelPomp

使用 R 包 panelPomp 分析部分可观测马尔可夫面板过程的教程

The R package panelPomp supports analysis of panel data via a general class of partially observed Markov process models (PanelPOMP). This package tutorial describes how the mathematical concept of a PanelPOMP is represented in the software and demonstrates typical use-cases of panelPomp. Monte Carlo methods used for POMP models require adaptation for PanelPOMP models due to the higher dimensionality of panel data. The package takes advantage of recent advances for PanelPOMP,…

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Multiply-Robust Causal Change Attribution

多重稳健的因果变化归因

Comparing two samples of data, we observe a change in the distribution of an outcome variable. In the presence of multiple explanatory variables, how much of the change can be explained by each possible cause? We develop a new estimation strategy that, given a causal model, combines regression and re-weighting methods to quantify the contribution of each causal mechanism. Our proposed methodology is multiply robust, meaning that it still recovers the target parameter under…

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Bias correction of posterior means using MCMC outputs

利用 MCMC 输出校正后验均值的偏差

We propose algorithms for addressing the bias of the posterior mean when used as an estimator of parameters. These algorithms build upon the recently proposed Bayesian infinitesimal jackknife approximation (Giordano and Broderick (2023)) and can be implemented using the posterior covariance and third-order combined cumulants easily calculated from MCMC outputs. Two algorithms are introduced: The first algorithm utilises the output of a single-run MCMC with the original…

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The Geometry and Well-Posedness of Sparse Regularized Linear Regression

稀疏正则化线性回归的几何与适定性

In this work, we study the well-posedness of certain sparse regularized linear regression problems, i.e., the existence, uniqueness and continuity of the solution map with respect to the data. We focus on regularization functions that are convex piecewise linear, i.e., whose epigraph is polyhedral. This includes total variation on graphs and polyhedral constraints. We provide a geometric framework for these functions based on their connection to polyhedral sets and apply…

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On the edge eigenvalues of the precision matrices of nonstationary autoregressive processes

非平稳自回归过程精度矩阵的边缘特征值

This paper investigates structural changes in the parameters of first-order autoregressive models by analyzing the edge eigenvalues of the precision matrices. Specifically, edge eigenvalues in the precision matrix are observed if and only if there is a structural change in the autoregressive coefficients. We show that these edge eigenvalues correspond to the zeros of a determinantal equation. Additionally, we propose a consistent estimator for detecting outliers within the…

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Co-Developing Causal Graphs with Domain Experts Guided by Weighted FDR-Adjusted p-values

以加权多重检验调整后的 p 值辅助领域专家共建因果图

This paper proposes an approach facilitating co-design of causal graphs between subject matter experts and statistical modellers. Modern causal analysis starting with formulation of causal graphs provides benefits for robust analysis and well-grounded decision support. Moreover, this process can enrich the discovery and planning phase of data science projects. The key premise is that plotting relevant statistical information on a causal graph structure can facilitate an…

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Penalized Subgrouping of Heterogeneous Time Series

异质性时间序列的惩罚化子群划分

Interest in the study and analysis of dynamic processes in the social, behavioral, and health sciences has burgeoned in recent years due to the increased availability of intensive longitudinal data. However, how best to model and account for the persistent heterogeneity characterizing such processes remains an open question. The multi-VAR framework, a recent methodological development built on the vector autoregressive model, accommodates heterogeneous dynamics in…

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Likelihood estimation for stochastic differential equations with mixed effects

混合效应随机微分方程的似然估计

Stochastic differential equations provide a powerful tool for modelling dynamic phenomena affected by random noise. In case of repeated observations of time series for several experimental units, it is often the case that some of the parameters vary between the individual experimental units, which has motivated a considerable interest in stochastic differential equations with mixed effects, where a subset of the parameters are random. These models enable simultaneous…

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Cost-Effectiveness Analysis for Disease Prevention -- A Case Study on Colorectal Cancer Screening

疾病预防的成本效果分析:结直肠癌筛查案例

Cancer Screening has been widely recognized as an effective strategy for preventing the disease. Despite its effectiveness, determining when to start screening is complicated, because starting too early increases the number of screenings over lifetime and thus costs but starting too late may miss the cancer that could have been prevented. Therefore, to make an informed recommendation on the age to start screening, it is necessary to conduct cost-effectiveness analysis to…

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Ab initio uncertainty quantification in scattering analysis of microscopy

显微成像散射分析中的从源头不确定性量化

Estimating parameters from data is a fundamental problem, customarily done by minimizing a loss function between a model and observed statistics. In scattering-based analysis, researchers often employ their domain expertise to select a specific range of wave vectors for analysis, a choice that can vary depending on the specific case. We introduce another paradigm that defines a probabilistic generative model from the beginning of data processing and propagates the…

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Safe Policy Learning under Regression Discontinuity Designs with Multiple Cutoffs

多阈值断点回归设计下的安全政策学习

The regression discontinuity (RD) design is widely used for program evaluation with observational data. The primary focus of the existing literature has been the estimation of the local average treatment effect at the existing treatment cutoff. In contrast, we consider policy learning under the RD design. Because the treatment assignment mechanism is deterministic, learning better treatment cutoffs requires extrapolation. We develop a robust optimization approach to finding…

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Large-scale Multiple Testing of Cross-covariance Functions with Applications to Functional Network Models

交叉协方差函数的大规模多重检验及其在函数网络模型中的应用

The estimation of functional networks through functional covariance and graphical models have recently attracted increasing attention in settings with high dimensional functional data, where the number of functional variables p is comparable to, and maybe larger than, the number of subjects. However, the existing methods all depend on regularization techniques, which make it unclear how the involved tuning parameters are related to the number of false edges. In this paper,…

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Fitting an Equation to Data Impartially

对称地拟合数据中的方程关系

We consider the problem of fitting a relationship (e.g. a potential scientific law) to data involving multiple variables. Ordinary (least squares) regression is not suitable for this because the estimated relationship will differ according to which variable is chosen as being dependent, and the dependent variable is unrealistically assumed to be the only variable which has any measurement error (noise). We present a very general method for estimating a linear functional…

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Rank-transformed subsampling: inference for multiple data splitting and exchangeable p-values

秩变换子抽样:多重数据划分与可交换 p 值的推断

Many testing problems are readily amenable to randomised tests such as those employing data splitting. However despite their usefulness in principle, randomised tests have obvious drawbacks. Firstly, two analyses of the same dataset may lead to different results. Secondly, the test typically loses power because it does not fully utilise the entire sample. As a remedy to these drawbacks, we study how to combine the test statistics or p-values resulting from multiple random…

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A Principal Square Response Forward Regression Method for Dimension Reduction

主平方响应前向回归的降维方法

Dimension reduction techniques, such as Sufficient Dimension Reduction (SDR), are indispensable for analyzing high-dimensional datasets. This paper introduces a novel SDR method named Principal Square Response Forward Regression (PSRFR) for estimating the central subspace of the response variable Y, given the vector of predictor variables $\bm{X}$. We provide a computational algorithm for implementing PSRFR and establish its consistency and asymptotic properties. Monte Carlo…

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Double Machine Learning at Scale to Predict Causal Impact of Customer Actions

大规模双重机器学习:预测客户行为的因果影响

Causal Impact (CI) of customer actions are broadly used across the industry to inform both short- and long-term investment decisions of various types. In this paper, we apply the double machine learning (DML) methodology to estimate the CI values across 100s of customer actions of business interest and 100s of millions of customers. We operationalize DML through a causal ML library based on Spark with a flexible, JSON-driven model configuration approach to estimate CI at…

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Simulation-calibration testing for inference in Lasso regressions

Lasso 回归推断的模拟校准检验

We propose a test of the significance of a variable appearing on the Lasso path and use it in a procedure for selecting one of the models of the Lasso path, controlling the Family-Wise Error Rate. Our null hypothesis depends on a set A of already selected variables and states that it contains all the active variables. We focus on the regularization parameter value from which a first variable outside A is selected. As the test statistic, we use this quantity's conditional…

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Estimand-based Inference in Presence of Long-Term Survivors

存在长期存活者时基于目标量的推断

In this article, we develop nonparametric inference methods for comparing survival data across two samples, which are beneficial for clinical trials of novel cancer therapies where long-term survival is a critical outcome. These therapies, including immunotherapies or other advanced treatments, aim to establish durable effects. They often exhibit distinct survival patterns such as crossing or delayed separation and potentially leveling-off at the tails of survival curves,…

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A sparse PAC-Bayesian approach for high-dimensional quantile prediction

高维分位数预测的稀疏 PAC-Bayes 方法

Quantile regression, a robust method for estimating conditional quantiles, has advanced significantly in fields such as econometrics, statistics, and machine learning. In high-dimensional settings, where the number of covariates exceeds sample size, penalized methods like lasso have been developed to address sparsity challenges. Bayesian methods, initially connected to quantile regression via the asymmetric Laplace likelihood, have also evolved, though issues with posterior…

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Inference for linear functionals of high-dimensional longitudinal proteomics data using generalized estimating equations

高维纵向蛋白质组数据中广义估计方程线性泛函的推断

Regression analysis of correlated data, where multiple correlated responses are recorded on the same unit, is ubiquitous in many scientific areas. With the advent of new technologies, in particular high-throughput omics profiling assays, such correlated data increasingly consist of large number of variables compared with the available sample size. Motivated by recent longitudinal proteomics studies of COVID-19, we propose a novel inference procedure for linear functionals of…

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Uplift Modeling Under Limited Supervision

有限监督下的增益建模

Estimating causal effects in e-commerce tends to involve costly treatment assignments which can be impractical in large-scale settings. Leveraging machine learning to predict such treatment effects without actual intervention is a standard practice to diminish the risk. However, existing methods for treatment effect prediction tend to rely on training sets of substantial size, which are built from real experiments and are thus inherently risky to create. In this work we…

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Double Machine Learning meets Panel Data -- Promises, Pitfalls, and Potential Solutions

双重机器学习与面板数据:潜力、陷阱及可能的解决方案

Estimating causal effect using machine learning (ML) algorithms can help to relax functional form assumptions if used within appropriate frameworks. However, most of these frameworks assume settings with cross-sectional data, whereas researchers often have access to panel data, which in traditional methods helps to deal with unobserved heterogeneity between units. In this paper, we explore how we can adapt double/debiased machine learning (DML) (Chernozhukov et al., 2018)…

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Bayesian nonparametric mixtures of categorical directed graphs for heterogeneous causal inference

用于异质性因果推断的分类变量有向图贝叶斯非参数混合模型

Quantifying causal effects of exposures on outcomes, such as a treatment and a disease respectively, is a crucial issue in medical science for the administration of effective therapies. Importantly, any related causal analysis should account for all those variables, e.g. clinical features, that can act as risk factors involved in the occurrence of a disease. In addition, the selection of targeted strategies for therapy administration requires to quantify such treatment…

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Learning linear acyclic causal model including Gaussian noise using ancestral relationships

利用祖先关系学习含高斯噪声的线性无环因果模型

This paper discusses algorithms for learning causal DAGs. The PC algorithm makes no assumptions other than the faithfulness to the causal model and can identify only up to the Markov equivalence class. LiNGAM assumes linearity and continuous non-Gaussian disturbances for the causal model, and the causal DAG defining LiNGAM is shown to be fully identifiable. The PC-LiNGAM, a hybrid of the PC algorithm and LiNGAM, can identify up to the distribution-equivalence pattern of a…

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