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Existence of solutions to the nonlinear equations characterizing the precise error of M-estimators

刻画M估计量精确误差的非线性方程解的存在性

Major progress has been made in the previous decade to characterize the asymptotic behavior of regularized M-estimators in high-dimensional regression problems in the proportional asymptotic regime where the sample size $n$ and the number of features $p$ are increasing simultaneously such that $n/p\to δ\in(0,\infty)$, using powerful tools such as Approximate Message Passing or the Convex Gaussian Min-Max Theorem (CGMT). The asymptotic error and behavior of the regularized…

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Large Scale Longitudinal Experiments: Estimation and Inference

大规模纵向实验:估计与推断

Large-scale randomized experiments are seldom analyzed using panel regression methods because of computational challenges arising from the presence of millions of nuisance parameters. We leverage Mundlak's insight that unit intercepts can be eliminated by using carefully chosen averages of the regressors to rewrite several common estimators in a form that is amenable to weighted-least squares estimation with frequency weights. This renders regressions involving arbitrary…

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Detecting Structural Shifts and Estimating Change-Points in Interval-Based Time Series

区间型时间序列的结构变化检测与变点估计

This paper addresses the open problem of conducting change-point analysis for interval-valued time series data using the maximum likelihood estimation (MLE) framework. Motivated by financial time series, we analyze data that includes daily opening (O), up (U), low (L), and closing (C) values, rather than just a closing value as traditionally used. To tackle this, we propose a fundamental model based on stochastic differential equations, which also serves as a transformation…

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Deflated HeteroPCA: Overcoming the curse of ill-conditioning in heteroskedastic PCA

Deflated HeteroPCA:克服异方差主成分分析的病态条件数问题

This paper is concerned with estimating the column subspace of a low-rank matrix $\boldsymbol{X}^\star \in \mathbb{R}^{n_1\times n_2}$ from contaminated data. How to obtain optimal statistical accuracy while accommodating the widest range of signal-to-noise ratios (SNRs) becomes particularly challenging in the presence of heteroskedastic noise and unbalanced dimensionality (i.e., $n_2\gg n_1$). While the state-of-the-art algorithm $\textsf{HeteroPCA}$ emerges as a powerful…

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Multivariate Tie-breaker Designs

多变量中间区间随机化设计

In a tie-breaker design (TBD), subjects with high values of a running variable are given some (usually desirable) treatment, subjects with low values are not, and subjects in the middle are randomized. TBDs are intermediate between regression discontinuity designs (RDDs) and randomized controlled trials (RCTs). TBDs allow a tradeoff between the resource allocation efficiency of an RDD and the statistical efficiency of an RCT. We study a model where the expected response is…

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Bayesian inference for partial orders from random linear extensions: power relations from 12th Century Royal Acta

由随机线性扩展推断偏序:十二世纪王室文书中的权力关系

In the eleventh and twelfth centuries in England, Wales and Normandy, Royal Acta were legal documents in which witnesses were listed in order of social status. Any bishops present were listed as a group. For our purposes, each witness-list is an ordered permutation of bishop names with a known date or date-range. Changes over time in the order bishops are listed may reflect changes in their authority. Historians would like to detect and quantify these changes. There is no…

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Model-based clustering of time-dependent observations with common structural changes

基于共同结构变化的时间序列模型聚类

We propose a novel model-based clustering approach for samples of time series. We assume as a unique commonality that two observations belong to the same group if structural changes in their behaviours happen at the same time. We resort to a latent representation of structural changes in each time series based on random orders to induce ties among different observations. Such an approach results in a general modeling strategy and can be combined with many time-dependent…

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Instrumental Variable Approach to Estimating Individual Causal Effects in N-of-1 Trials: Application to ISTOP Study

N-of-1 试验中个体因果效应的工具变量估计:ISTOP 应用

An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advancements in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different…

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Measurement Error Correction for Spatially Defined Environmental Exposures in Survival Analysis

生存分析中空间定义环境暴露的测量误差校正

Environmental exposures are often defined using buffer zones around geocoded home addresses, but these static boundaries can miss dynamic daily activity patterns, leading to biased results. This paper presents a novel measurement error correction method for spatially defined environmental exposures within a survival analysis framework using the Cox proportional hazards model. The method corrects high-dimensional surrogate exposures from geocoded residential data at multiple…

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A Generalized Difference-in-Differences Estimator for Randomized Stepped-Wedge and Observational Staggered Adoption Settings

适用于随机阶梯楔形与观察性交错采用的广义双重差分估计

Staggered treatment adoption arises in the evaluation of policy impact and implementation in many settings, including both randomized stepped-wedge trials and non-randomized quasi-experiments with panel data. In both settings, getting an interpretable, unbiased effect estimate requires careful consideration of the target estimand and possible treatment effect heterogeneities. This paper proposes a novel non-parametric approach to this estimation for either setting. By…

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Probabilistic Inversion Modeling of Gas Emissions: A Gradient-Based MCMC Estimation of Gaussian Plume Parameters

气体排放的概率反演建模:基于梯度的MCMC估计高斯烟羽参数

In response to global concerns regarding air quality and the environmental impact of greenhouse gas emissions, detecting and quantifying sources of emissions has become critical. To understand this impact and target mitigations effectively, methods for accurate quantification of greenhouse gas emissions are required. In this paper, we focus on the inversion of concentration measurements to estimate source location and emission rate. In practice, such methods often rely on…

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Multiple conditional randomization tests for lagged and spillover treatment effects

滞后与溢出处理效应的多个条件随机化检验

We consider the problem of constructing multiple independent conditional randomization tests using a single dataset. Because the tests are independent, the randomization p-values can be interpreted individually and combined using standard methods for multiple testing. We give a simple, sequential construction of such tests, and then discuss its application to three problems: Rosenbaum's evidence factors for observational studies, lagged treatment effect in stepped-wedge…

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A primer on linear classification with missing data

缺失数据下线性分类方法入门

Supervised learning with missing data aims at building the best prediction of a target output based on partially-observed inputs. Major approaches to address this problem can be decomposed into $(i)$ impute-then-predict strategies, which first fill in the empty input components and then apply a unique predictor and $(ii)$ Pattern-by-Pattern (P-b-P) approaches, where a predictor is built on each missing pattern. In this paper, we theoretically analyze how three classical…

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Federated Offline Policy Learning

联邦离线策略学习

We consider the problem of learning personalized decision policies from observational bandit feedback data across multiple heterogeneous data sources. In our approach, we introduce a novel regret analysis that establishes finite-sample upper bounds on distinguishing notions of global regret for all data sources on aggregate and of local regret for any given data source. We characterize these regret bounds by expressions of source heterogeneity and distribution shift.…

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Robust Offline Policy Learning with Observational Data from Multiple Sources

利用多来源观察数据开展鲁棒离线策略学习

We consider the problem of using observational bandit feedback data from multiple heterogeneous data sources to learn a personalized decision policy that robustly generalizes across diverse target settings. To achieve this, we propose a minimax regret optimization objective to ensure uniformly low regret under general mixtures of the source distributions. We develop a policy learning algorithm tailored to this objective, combining doubly robust offline policy evaluation…

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A causal inference framework for spatial confounding

空间混杂的因果推断框架

Over the past few decades, addressing "spatial confounding" has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed solutions are tied to specific analysis models and do not address the issue of confounding as it is understood in causal inference. We offer an analysis-model-agnostic definition of spatial confounding as the existence of an unmeasured causal confounder variable with a spatial structure. We…

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Addressing selection bias in cluster randomized experiments via weighting

通过加权处理整群随机试验中的选择偏差

In cluster randomized experiments, individuals are often recruited after the cluster treatment assignment, and data are typically only available for the recruited sample. Post-randomization recruitment can lead to selection bias, inducing systematic differences between the overall and the recruited populations, and between the recruited intervention and control arms. In this setting, we define causal estimands for the overall and the recruited populations. We prove, under…

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General Covariance-Based Conditions for Central Limit Theorems with Dependent Triangular Arrays

依赖三角阵中心极限定理的一般协方差条件

We present a general central limit theorem with simple, easy-to-check covariance-based sufficient conditions for triangular arrays of random vectors when all variables could be interdependent. The result is constructed from Stein's method, but the conditions are distinct from related work. We show that these covariance conditions nest standard assumptions studied in the literature such as $M$-dependence, mixing random fields, non-mixing autoregressive processes, and…

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Causal Inference for Continuous Multiple Time Point Interventions

连续多时点干预的因果推断

There are limited options to estimate the treatment effects of variables which are continuous and measured at multiple time points, particularly if the true dose-response curve should be estimated as closely as possible. However, these situations may be of relevance: in pharmacology, one may be interested in how outcomes of people living with -- and treated for -- HIV, such as viral failure, would vary for time-varying interventions such as different drug concentration…

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Sparse higher order partial least squares for simultaneous variable selection, dimension reduction, and tensor denoising

稀疏高阶偏最小二乘:同时变量选择、降维与张量去噪

Partial Least Squares (PLS) regression emerged as an alternative to ordinary least squares for addressing multicollinearity in a wide range of scientific applications. As multidimensional tensor data is becoming more widespread, tensor adaptations of PLS have been developed. In this paper, we first establish the statistical behavior of Higher Order PLS (HOPLS) of Zhao et al. (2012), by showing that the consistency of the HOPLS estimator cannot be guaranteed as the tensor…

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Penalized regression with negative-unlabeled data: An approach to developing a long COVID research index

负-未标注数据下的惩罚回归:构建长新冠研究指数的方法

Moderate to severe post-acute sequelae of SARS-CoV-2 infection (PASC), also called long COVID, is estimated to impact as many as 10% of SARS-CoV-2 infected individuals, representing a chronic condition with a substantial global public health burden. An expansive literature has identified over 200 long-term and persistent symptoms associated with a history of SARS-CoV-2 infection; yet, there remains to be a clear consensus on a syndrome definition. Such a definition is a…

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Modeling Causal Mechanisms with Diffusion Models for Interventional and Counterfactual Queries

利用扩散模型刻画因果机制并回答干预与反事实问题

We consider the problem of answering observational, interventional, and counterfactual queries in a causally sufficient setting where only observational data and the causal graph are available. Utilizing the recent developments in diffusion models, we introduce diffusion-based causal models (DCM) to learn causal mechanisms, that generate unique latent encodings. These encodings enable us to directly sample under interventions and perform abduction for counterfactuals.…

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Local Effects of Continuous Instruments without Positivity

无需正值性假设的连续工具变量局部效应

Instrumental variables are a popular study design for the estimation of treatment effects in the presence of unobserved confounders. In the canonical instrumental variables design, the instrument is a binary variable. In many settings, however, the instrument is continuous. Standard estimation methods can be applied with continuous instruments, but they require strong assumptions. While recent work has introduced more flexible estimation approaches, these methods require a…

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Finitely Heterogeneous Treatment Effect in Event-study

事件研究中的有限类型异质性处理效应

A key assumption of the differences-in-differences designs is that the average evolution of untreated potential outcomes is the same across different treatment cohorts: a parallel trends assumption. In this paper, we relax the parallel trend assumption by assuming a latent type variable and developing a type-specific parallel trend assumption. With a finite support assumption on the latent type variable and long pretreatment time periods, we show that an extremum classifier…

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