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Debiased Nonparametric Regression for Statistical Inference and Distributionally Robustness

用于统计推断与分布稳健性的去偏非参数回归

This study proposes a debiasing method for smooth nonparametric estimators. While machine learning techniques such as random forests and neural networks have demonstrated strong predictive performance, their theoretical properties remain relatively underexplored. In particular, many modern algorithms lack guarantees of pointwise and uniform risk convergence, as well as asymptotic normality. These properties are essential for statistical inference and robust estimation and…

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Tracking the Hidden Forces Behind Laos' 2022 Exchange Rate Crisis and Balance of Payments Instability

追踪老挝 2022 年汇率危机与国际收支不稳定背后的潜在因素

This working paper uses a Dynamic Factor Model ('the model') to identify underlying factors contributing to the debt-induced economic crisis in the People's Democratic Republic of Laos ('Laos'). The analysis aims to use the latent macroeconomic insights to propose ways forward for forecasting. We focus on Laos's historic structural weaknesses to identify when a balance of payments crisis with either a persistent current account imbalance or rapid capital outflows would…

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fkbma: An R Package for Detecting Tailoring Variables with Free-Knot B-Splines and Bayesian Model Averaging

fkbma:以自由节点 B 样条和贝叶斯模型平均识别治疗定制变量的 R 包

Precision medicine aims to optimize treatment by identifying patient subgroups most likely to benefit from specific interventions. To support this goal, we introduce fkbma, an R package that implements a Bayesian model averaging approach with free-knot B-splines for identifying tailoring variables. The package employs a reversible jump Markov chain Monte Carlo algorithm to flexibly model treatment effect heterogeneity while accounting for uncertainty in both variable…

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A robust score test in g-computation for covariate adjustment in randomized clinical trials leveraging different variance estimators via influence functions

随机临床试验协变量调整中基于影响函数方差的稳健 g 计算得分检验

G-computation has become a widely used robust method for estimating unconditional (marginal) treatment effects with covariate adjustment in the analysis of randomized clinical trials. Statistical inference in this context typically relies on the Wald test or Wald interval, which can be easily implemented using a consistent variance estimator. However, existing literature suggests that when sample sizes are small or when parameters of interest are near boundary values,…

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H-AddiVortes: Heteroscedastic (Bayesian) Additive Voronoi Tessellations

异方差贝叶斯加性 Voronoi 镶嵌模型

This paper introduces the Heteroscedastic AddiVortes model, a Bayesian non-parametric regression framework that simultaneously models the conditional mean and variance of a response variable using adaptive Voronoi tessellations. By employing a sum-of-tessellations approach for the mean and a product-of-tessellations approach for the variance, the model provides a flexible and interpretable means to capture complex, predictor-dependent relationships and heteroscedastic…

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Exponential Inequalities for Some Mixing Processes and Dynamic Systems

若干混合过程与动力系统的指数不等式

Many important dynamic systems, time series models or even algorithms exhibit non-strong mixing properties. In this paper, we introduce the general concept of $\mathcal{C}_{p,\mathcal{F}}$-mixing to cover such cases, where assumptions on the dependence structure become stronger with increasing $p\in [1, \infty].$ We derive a series of sharp exponential-type (or Bernstein-type) inequalities under this dependence concept for $p=1$ and $p=\infty$. More specifically, $\mathcal{C}_{\infty,\mathcal{F}}$…

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Compositional Models for Estimating Causal Effects

用于因果效应估计的组合式模型

Many real-world systems can be usefully represented as sets of interacting components. Examples include computational systems, such as query processors and compilers, natural systems, such as cells and ecosystems, and social systems, such as families and organizations. However, current approaches to estimating potential outcomes and causal effects typically treat such systems as single units, represent them with a fixed set of variables, and assume a homogeneous…

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A Doubly Robust Instrumental Variable Approach for Estimating Average Treatment Effects in Time-to-Event Data with Unmeasured Confounding: Application to Real-World Data on ICU Patients with Septic Shock

未测混杂下生存结局平均处理效应的双重稳健工具变量方法

Motivated by conflicting conclusions regarding hydrocortisone's treatment effect on ICU patients with vasopressor-dependent septic shock, we developed a novel instrumental variable (IV) estimator to assess the average treatment effect (ATE) in time-to-event data. In real-world data, IV methods are widely used for estimating causal treatment effects in the presence of unmeasured confounding, but existing approaches for time-to-event outcomes are often constrained by strong…

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Sequential Kernel Embedding for Mediated and Time-Varying Dose Response Curves

中介与时变剂量反应曲线的序贯核嵌入

We propose simple nonparametric estimators for mediated and time-varying dose response curves based on kernel ridge regression. By embedding Pearl's mediation formula and Robins' g-formula with kernels, we allow treatments, mediators, and covariates to be continuous in general spaces, and also allow for nonlinear treatment-confounder feedback. Our key innovation is a reproducing kernel Hilbert space technique called sequential kernel embedding, which we use to construct…

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BudgetIV: Optimal Partial Identification of Causal Effects with Mostly Invalid Instruments

BudgetIV:多数工具变量无效时因果效应的最优部分识别

Instrumental variables (IVs) are widely used to estimate causal effects in the presence of unobserved confounding between exposure and outcome. An IV must affect the outcome exclusively through the exposure and be unconfounded with the outcome. We present a framework for relaxing either or both of these strong assumptions with tuneable and interpretable budget constraints. Our algorithm returns a feasible set of causal effects that can be identified exactly given relevant…

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Causal Representation Learning from Multimodal Biomedical Observations

从多模态生物医学观测中学习因果表征

Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these datasets often lack interpretability and identifiability guarantees, which are essential for biomedical research. Recent advances in causal representation learning have shown promise in identifying interpretable latent causal variables with…

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Identification and estimation of structural vector autoregressive models via LU decomposition

利用 LU 分解识别与估计结构向量自回归模型

Structural vector autoregressive (SVAR) models are widely used to analyze the simultaneous relationships between multiple time-dependent data. Various statistical inference methods have been studied to overcome the identification problems of SVAR models. However, most of these methods impose strong assumptions for innovation processes such as the uncorrelation of components. In this study, we relax the assumptions for innovation processes and propose an identification method…

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Simultaneous inference for generalized linear models with unmeasured confounders

含未测混杂因素的广义线性模型同时推断

Tens of thousands of simultaneous hypothesis tests are routinely performed in genomic studies to identify differentially expressed genes. However, due to unmeasured confounders, many standard statistical approaches may be substantially biased. This paper investigates the large-scale hypothesis testing problem for multivariate generalized linear models in the presence of confounding effects. Under arbitrary confounding mechanisms, we propose a unified statistical estimation…

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The Probability of Tiered Benefit: Partial Identification with Robust and Stable Inference

分层获益概率:部分识别与稳健、稳定的推断

We define the Probability of Tiered Benefit in scenarios with a binary exposure and an outcome that is either categorical with $K \geq 2$ ordered tiers or continuous partitioned by $K-1$ fixed thresholds into disjoint intervals. Similarly to other pure counterfactual queries, this parameter is not $g$-identifiable without additional assumptions. We demonstrate that strong monotonicity does not suffice for point identification when $K \geq 3$ and provide sharp bounds both…

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Penalized Principal Component Analysis for Large-dimension Factor Model with Group Pursuit

带群组识别的高维因子模型惩罚主成分分析

This paper investigates the intrinsic group structures within the framework of large-dimensional approximate factor models, which portrays homogeneous effects of the common factors on the individuals that fall into the same group. To this end, we propose a fusion Penalized Principal Component Analysis (PPCA) method and derive a closed-form solution for the $\ell_2$-norm optimization problem. We also show the asymptotic properties of our proposed PPCA estimates. With the PPCA…

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Longitudinal Causal Inference with Selective Eligibility

具有选择性资格的纵向因果推断

Dropout poses a significant challenge to causal inference in longitudinal studies with time-varying treatments. However, existing research does not simultaneously address dropout and time-varying treatments. We examine selective eligibility, an important yet overlooked source of non-ignorable dropout in such settings. This problem arises when a unit's prior treatment history influences its eligibility for subsequent treatments, a common scenario in medical and other…

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Graph Topic Modeling for Documents with Spatial or Covariate Dependencies

面向具有空间或协变量依赖文档的图主题建模

We address the challenge of incorporating document-level metadata into topic modeling to improve topic mixture estimation. To overcome the computational complexity and lack of theoretical guarantees in existing Bayesian methods, we extend probabilistic latent semantic indexing (pLSI), a frequentist framework for topic modeling, by incorporating document-level covariates or known similarities between documents through a graph formalism. Modeling documents as nodes and edges…

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Estimating interaction effects with panel data

面板数据交互效应的估计

This paper analyzes how interaction effects can be consistently estimated under economically plausible assumptions in linear panel models with a fixed $T$-dimension. We advocate for a \emph{correlated interaction term estimator} (CITE) and show that it is consistent under conditions that are not sufficient for consistency of the interaction term estimator that is most common in applied econometric work. Our paper discusses the empirical content of these conditions, shows…

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Spatiotemporal clustering of GHGs emissions in Europe: exploring the role of spatial component

欧洲温室气体排放的时空聚类:空间成分的作用

In this study, we propose a novel application of spatiotemporal clustering in the environmental sciences, with a particular focus on regionalised time series of greenhouse gases (GHGs) emissions from a range of economic sectors. Utilising a hierarchical spatiotemporal clustering methodology, we analyse yearly time series of emissions by gases and sectors from 1990 to 2022 for European regions at the NUTS-2 level. While the clustering algorithm inherently incorporates spatial…

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Excess Mean Squared Error of Empirical Bayes Estimators

经验贝叶斯估计量的超额均方误差

Empirical Bayes estimators are based on minimizing the average risk with the hyper-parameters in the weighting function being estimated from observed data. The performance of an empirical Bayes estimator is typically evaluated by its mean squared error (MSE). However, the explicit expression for its MSE is generally unavailable for finite sample sizes. To address this issue, we define a high-order analytical criterion: the excess MSE. It quantifies the performance difference…

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Causal Quantile Treatment Effects with missing data by double-sampling

通过双重抽样处理缺失数据的因果分位数处理效应

Causal weighted quantile treatment effects (WQTE) are a useful complement to standard causal contrasts that focus on the mean when interest lies at the tails of the counterfactual distribution. To-date, however, methods for estimation and inference regarding causal WQTEs have assumed complete data on all relevant factors. In most practical settings, however, data will be missing or incomplete data, particularly when the data are not collected for research purposes, as is the…

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Modeling complex measurement error in microbiome experiments to estimate relative abundances and detection effects

微生物组实验中复杂测量误差的建模:相对丰度与检测效应估计

Accurate estimates of microbial species abundances are needed to advance our understanding of the role that microbiomes play in human and environmental health. However, artificially constructed microbiomes demonstrate that intuitive estimators of microbial relative abundances are biased. To address this, we propose a semiparametric method to estimate relative abundances, species detection effects, and/or cross-sample contamination in microbiome experiments. We show that…

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On the numerical approximation of minimax regret rules via fictitious play

通过虚拟博弈数值逼近极小极大遗憾规则

Finding numerical approximations to minimax regret treatment rules is of key interest. To do so when potential outcomes are in {0,1} we discretize the action space of nature and apply a variant of Robinson's (1951) algorithm for iterative solutions for finite two-person zero sum games. Our approach avoids the need to evaluate regret of each treatment rule in each iteration. When potential outcomes are in [0,1] we apply the so-called coarsening approach. We consider a…

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Generalized network autoregressive modelling of longitudinal networks with application to presidential elections in the USA

纵向网络的广义网络自回归建模及美国总统选举应用

Longitudinal networks are becoming increasingly relevant in the study of dynamic processes characterised by known or inferred community structure. Generalised Network Autoregressive (GNAR) models provide a parsimonious framework for exploiting the underlying network and multivariate time series. We introduce the community-$α$ GNAR model with interactions that exploits prior knowledge or exogenous variables for analysing interactions within and between communities, and can…

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