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The Fundamental Limits of Structure-Agnostic Functional Estimation

不依赖结构的泛函估计之基本极限

Many recent developments in causal inference, and functional estimation problems more generally, have been motivated by the fact that classical one-step (first-order) debiasing methods, or their more recent sample-split double machine-learning avatars, can outperform plugin estimators under surprisingly weak conditions. These first-order corrections improve on plugin estimators in a black-box fashion, and consequently are often used in conjunction with powerful off-the-shelf…

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Practically significant differences between conditional distribution functions

条件分布函数之间具有实际意义的差异

In the framework of semiparametric distribution regression, we consider the problem of comparing the conditional distribution functions corresponding to two samples. In contrast to testing for exact equality, we are interested in the (null) hypothesis that the $L^2$ distance between the conditional distribution functions does not exceed a certain threshold in absolute value. The consideration of these hypotheses is motivated by the observation that in applications, it is…

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Bayesian variable selection in a Cox proportional hazards model with the "Sum of Single Effects" prior

采用单效应之和先验的 Cox 比例风险模型贝叶斯变量选择

Motivated by genetic fine-mapping applications, we introduce a new approach to Bayesian variable selection regression (BVSR) for time-to-event (TTE) outcomes. This new approach is designed to deal with the specific challenges that arise in genetic fine-mapping, including: the presence of very strong correlations among the covariates, often exceeding 0.99; very large data sets containing potentially thousands of covariates and hundreds of thousands of samples. We accomplish…

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Marchenko-Pastur laws for Daniell smoothed periodograms

Daniell 平滑周期图的 Marchenko–Pastur 定律

Given a sample $X_0,...,X_{n-1}$ from a $d$-dimensional stationary time series $(X_t)_{t \in \mathbb{Z}}$, the most commonly used estimator for the spectral density matrix $F(θ)$ at a given frequency $θ\in [0,2π)$ is the Daniell smoothed periodogram $$S(θ) = \frac{1}{2m+1} \sum\limits_{j=-m}^m I\Big( θ+ \frac{2πj}{n} \Big) \ ,$$ which is an average over $2m+1$ many periodograms at slightly perturbed frequencies. We prove that the Marchenko-Pastur law holds for the…

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Ab Initio Nonparametric Variable Selection for Scalable Symbolic Regression with Large $p$

面向大规模符号回归的从头非参数变量选择

Symbolic regression (SR) is a powerful technique for discovering symbolic expressions that characterize nonlinear relationships in data, gaining increasing attention for its interpretability, compactness, and robustness. However, existing SR methods do not scale to datasets with a large number of input variables (referred to as extreme-scale SR), which is common in modern scientific applications. This ``large $p$'' setting, often accompanied by measurement error, leads to…

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Permutation-Free High-Order Interaction Tests

无需置换的高阶交互检验

Kernel-based hypothesis tests offer a flexible, non-parametric tool to detect high-order interactions in multivariate data, beyond pairwise relationships. Yet the scalability of such tests is limited by the computationally demanding permutation schemes used to generate null approximations. Here we introduce a family of permutation-free high-order tests for joint independence and partial factorisations of $d$ variables. Our tests eliminate the need for permutation-based…

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On Efficient Estimation of Distributional Treatment Effects under Covariate-Adaptive Randomization

协变量自适应随机化下分布治疗效应的有效估计

This paper focuses on the estimation of distributional treatment effects in randomized experiments that use covariate-adaptive randomization (CAR). These include designs such as Efron's biased-coin design and stratified block randomization, where participants are first grouped into strata based on baseline covariates and assigned treatments within each stratum to ensure balance across groups. In practice, datasets often contain additional covariates beyond the strata…

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Causal Effect Identification in lvLiNGAM from Higher-Order Cumulants

利用高阶累积量识别 lvLiNGAM 中的因果效应

This paper investigates causal effect identification in latent variable Linear Non-Gaussian Acyclic Models (lvLiNGAM) using higher-order cumulants, addressing two prominent setups that are challenging in the presence of latent confounding: (1) a single proxy variable that may causally influence the treatment and (2) underspecified instrumental variable cases where fewer instruments exist than treatments. We prove that causal effects are identifiable with a single proxy or…

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Distributional Matrix Completion via Nearest Neighbors in the Wasserstein Space

通过 Wasserstein 空间近邻进行分布矩阵补全

We study the problem of distributional matrix completion: Given a sparsely observed matrix of empirical distributions, we seek to impute the true distributions associated with both observed and unobserved matrix entries. This is a generalization of traditional matrix completion, where the observations per matrix entry are scalar-valued. To do so, we utilize tools from optimal transport to generalize the nearest neighbors method to the distributional setting. Under a suitable…

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Causal inference in network experiments: regression-based analysis and design-based properties

网络实验中的因果推断:回归分析与设计性质

Network experiments are powerful tools for studying spillover effects, which avoid endogeneity by randomly assigning treatments to units over networks. However, it is non-trivial to analyze network experiments properly without imposing strong modeling assumptions. We show that regression-based point estimators and standard errors can have strong theoretical guarantees if the regression functions and robust standard errors are carefully specified to accommodate the…

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Finite sample expansions and risk bounds in high-dimensional SLS models

高维SLS模型的有限样本展开与风险界

This note extends the results of classical parametric statistics like Fisher and Wilks theorem to modern setups with a high or infinite parameter dimension, limited sample size, and possible model misspecification. We consider a special class of stochastically linear smooth (SLS) models satisfying three major conditions: the stochastic component of the log-likelihood is linear in the model parameter and the expected log-likelihood is a smooth and concave function. For the…

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Enhancing the Merger Simulation Toolkit with ML/AI

用机器学习与人工智能扩展并购模拟工具

This paper develops a flexible approach to predict the price effects of horizontal mergers using ML/AI methods. While standard merger simulation techniques rely on restrictive assumptions about firm conduct, we propose a data-driven framework that relaxes these constraints when rich market data are available. We develop and identify a flexible nonparametric model of supply that nests a broad range of conduct models and cost functions. To overcome the curse of dimensionality,…

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Nonlinear Causal Discovery for Grouped Data

分组数据的非线性因果发现

Inferring cause-effect relationships from observational data has gained significant attention in recent years, but most methods are limited to scalar random variables. In many important domains, including neuroscience, psychology, social science, and industrial manufacturing, the causal units of interest are groups of variables rather than individual scalar measurements. Motivated by these applications, we extend nonlinear additive noise models to handle random vectors,…

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At the edge of Donsker's Theorem: Asymptotics of multiscale scan statistics

Donsker 定理的边界:多尺度扫描统计量的渐近理论

For nonparametric inference about a function, multiscale testing procedures resolve the need for bandwidth selection and achieve asymptotically optimal detection performance against a broad range of alternatives. However, critical values strongly depend on the noise distribution, and we argue that existing methods are either statistically infeasible, or asymptotically sub-optimal. To address this methodological challenge, we show how to develop a feasible multiscale test via…

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Distributed lag non-linear models with Laplacian-P-splines for analysis of spatially structured time series

用于空间结构时间序列的拉普拉斯 P 样条分布滞后非线性模型

Distributed lag non-linear models (DLNM) have gained popularity for modeling nonlinear lagged relationships between exposures and outcomes. When applied to spatially referenced data, these models must account for spatial dependence, a challenge that has yet to be thoroughly explored within the penalized DLNM framework. This gap is mainly due to the complex model structure and high computational demands, particularly when dealing with large spatio-temporal datasets. To…

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The continuous-time limit of quasi score-driven volatility models

拟得分驱动波动率模型的连续时间极限

This paper explores the continuous-time limit of a class of Quasi Score-Driven (QSD) models that characterize volatility. As the sampling frequency increases and the time interval tends to zero, the model weakly converges to a continuous-time stochastic volatility model where the two Brownian motions are correlated, thereby capturing the leverage effect in the market. Subsequently, we identify that a necessary condition for non-degenerate correlation is that the distribution…

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Proximal indirect comparison

近端间接比较

We consider the problem of indirect comparison, where a treatment arm of interest is absent by design in one randomized controlled trial but available in the other. The former is the target trial, and the latter is the source trial. The identifiability of the target population average treatment effect often relies on conditional transportability assumptions. However, it is a common concern whether all relevant effect modifiers are measured and controlled for. We give a new…

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Isolated Causal Effects of Natural Language

自然语言的孤立因果效应

As language technologies become widespread, it is important to understand how changes in language affect reader perceptions and behaviors. These relationships may be formalized as the isolated causal effect of some focal language-encoded intervention (e.g., factual inaccuracies) on an external outcome (e.g., readers' beliefs). In this paper, we introduce a formal estimation framework for isolated causal effects of language. We show that a core challenge of estimating…

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Recover Experimental Data with Selection Bias using Counterfactual Logic

用反事实逻辑恢复存在选择偏差的实验数据

Selection bias, arising from the systematic inclusion or exclusion of certain samples, poses a significant challenge to the validity of causal inference. While Bareinboim et al. introduced methods for recovering unbiased observational and interventional distributions from biased data using partial external information, the complexity of the backdoor adjustment and the method's strong reliance on observational data limit its applicability in many practical settings. In this…

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Leveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials

利用外部数据检验随机临床试验中的生物标志物交互效应

In oncology the efficacy of novel therapeutics often differs across patient subgroups, and these variations are difficult to predict during the initial phases of the drug development process. The relation between the power of randomized clinical trials and heterogeneous treatment effects has been discussed by several authors. In particular, false negative results are likely to occur when the treatment effects concentrate in a subpopulation but the study design did not…

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Robust and Agnostic Learning of Conditional Distributional Treatment Effects

条件分布处理效应的稳健与模型无关学习

The conditional average treatment effect (CATE) is the best measure of individual causal effects given baseline covariates. However, the CATE only captures the (conditional) average, and can overlook risks and tail events, which are important to treatment choice. In aggregate analyses, this is usually addressed by measuring the distributional treatment effect (DTE), such as differences in quantiles or tail expectations between treatment groups. Hypothetically, one can…

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Conventional and Fuzzy Data Envelopment Analysis with deaR

使用 deaR 进行常规与模糊数据包络分析

deaR is a recently developed R package for data envelopment analysis (DEA) that implements a large number of conventional and fuzzy models, along with super-efficiency models, cross-efficiency analysis, Malmquist index, bootstrapping, and metafrontier analysis. It should be noted that deaR is the only package to date that incorporates Kao-Liu, Guo-Tanaka and possibilistic fuzzy models. The versatility of the package allows the user to work with different returns to scale and…

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Mosaic inference on panel data

面板数据的马赛克推断

Analysis of panel data via linear regression is widespread across disciplines. To perform statistical inference, such analyses typically assume that clusters of observations are jointly independent. For example, one might assume that observations in New York are independent of observations in New Jersey. Are such assumptions plausible? Might there be hidden dependencies between nearby clusters? This paper introduces a mosaic permutation test that can (i) test the…

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Jointly modeling multiple endpoints for efficient treatment effect estimation in randomized controlled trials

联合建模多个终点以提高随机试验处理效应估计效率

Randomized controlled trials are the gold standard for evaluating the efficacy of an intervention. However, there is often a trade-off between selecting the most scientifically relevant primary endpoint versus a less relevant, but more powerful, endpoint. For example, in the context of tobacco regulatory science many trials evaluate cigarettes per day as the primary endpoint instead of abstinence from smoking due to limited power. Additionally, it is often of interest to…

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