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Estimating heterogeneous treatment effects from randomised trials: a comparison of the risk modelling and treatment effect modelling approaches

随机试验异质性处理效应估计:风险建模与效应建模比较

Introduction Risk modelling (RM) and treatment effect modelling (EM) are two approaches to build models to estimate heterogeneous treatment effects from randomized control trials (RCT). RM is a two-stage approach; it estimates a predicted baseline risk at the first stage and then includes it as the only effect modifier in a regression model in the second stage. EM is a full treatment interaction multivariable model. Both approaches have theoretical advantages and…

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A variational framework for modal estimation

众数估计的变分框架

Multivariate mode estimation arises in many statistical problems such as inverse problems, multimodal sampling, and density-based clustering, but becomes challenging in moderate to high dimensions, especially when the underlying density is not directly evaluable. We introduce GERVE (Gibbs-measure Entropy-Regularized Variational Estimation), a sample-based method for estimating multivariate modes by approximating Gibbs distributions directly from samples, without estimating…

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Summary Indices in Treatment Effect Estimation

处理效应估计中的综合指数

This paper studies the practice of combining multiple outcomes into a summary index to estimate a causal effect. For common estimators and index constructions, the estimate equals a weighted sum of the estimated effects on the components, with weights that are implicit and rarely reported. The paper derives the weights and shows that, for inverse-covariance-weighted indices, they can be negative and unrestricted in magnitude, so the index effect can have the opposite sign to…

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Robust Dual-Regularized Variable Selection under Outlier Contamination

异常值污染下的稳健双重正则化变量选择

Real data often contain unusual observations that can exert disproportionate effects on variable selection, especially in complex predictor settings. We propose a two-stage {\it sparse median outer product of gradients (smOPG)} method for variable selection in single index models with outlier contamination. We first estimate sparse local gradients via \(\ell_1\)-penalized local median regression and then recover the active predictor set from a rank-one sparse approximation…

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Asymptotic Anytime-Valid Quantile Inference under Local Differential Privacy

局部差分隐私下渐近随时有效的分位数推断

Sequential quantile inference is difficult under local differential privacy because every record is randomized before reaching the analyst and the limiting quantile variance depends on an unknown density. We develop an online procedure that combines randomized response with dynamically chained parallel stochastic gradient descent (P-SGD). The resulting Polyak--Ruppert estimator admits a strong Gaussian approximation. A cross-chain quadratic statistic, computed entirely from…

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Bias-Correction for Privacy-Protected Spatial Autoregressive Models with Application to Restaurant Network Analysis

隐私保护空间自回归模型的偏差校正与餐馆网络应用

Spatial autoregressive (SAR) models and their extensions are important tools for studying network effects. However, with an increasing emphasis on data privacy, data providers often implement protection measures that render standard SAR models inapplicable. In this study, we introduce a privacy-protected SAR model that incorporates noise into both the response and covariates to meet privacy requirements. With noise present in both components, the traditional quasi-maximum…

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Noise-adjusted turnover in estimated networks

估计网络中边更替的噪声校正

Economic networks are often estimated separately over two periods, and changes in their edge sets are interpreted as structural rewiring. Since both networks are estimated, observed turnover also reflects graph-selection error. We study the two-snapshot Hamming-turnover functional under a homogeneous edge-misclassification model. With known sensitivity and specificity and conditional independence of the estimated edge indicators across periods, latent turnover admits a…

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The Manifold Hypothesis under Unknown Gaussian Noise:Conditional Certificates and Consistent Dimension Estimation

未知高斯噪声下的流形假说:条件性证书与一致维数估计

We study what noisy data can establish about the Manifold Hypothesis under explicit identification and regularity conditions. A population residual certificate combines independent-view localization, Gaussian concentration, membership uncertainty, and population transfer. Existing rectifiability criteria then yield a covered-scale consequence. For a local smooth manifold with positive Hölder density, the actual-ball covariance limit identifies the spectral crossing with…

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Bridging Local and Population Causal Effects: A Proximal Instrumental Variable Approach

连接局部与总体因果效应:近端工具变量方法

Instrumental variable (IV) methods address treatment endogeneity, but with non-compliance and heterogeneous treatment effects a binary instrument generally identifies the local average treatment effect (LATE) among compliers rather than the population average treatment effect (ATE). When treatment effects and compliance probabilities are heterogeneous and dependent through latent factors, the ATE need not be identified by IV variation alone. We develop a proximal…

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Bayesian additive regression trees for evaluating treatment benefit predictors using observational data

用贝叶斯加性回归树评估观察数据中的治疗获益预测器

A treatment benefit predictor (TBP) is an algorithm that maps a patient's characteristics to their putative benefit from a given treatment, which can be used to inform treatment decisions. However, a TBP must be evaluated in the target population before being adopted for patient care. When only observational data are available, evaluating TBPs requires standard causal identification assumptions, as treatment assignment in such settings is not random. We obtain the posterior…

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Poisson Regression under Multivariate Sample Selection

多重样本选择下的泊松回归

This paper develops a Poisson regression model with multivariate sample selection, in which the outcome is observed only when several potentially correlated selection conditions are satisfied. To the best of our knowledge, this is the first Poisson sample selection model that allows for an arbitrary number of selection equations. We derive the conditional mean of the observed outcome under joint normality of the outcome and selection errors and obtain a multivariate…

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Targeted Function Balancing: Flexible balancing weights that leverage strategic imbalance to estimate causal effects

目标函数平衡:利用策略性不平衡估计因果效应

When estimating the average treatment effect of a binary intervention with weights, investigators are often burdened with how best to leave imbalance in the distributions of observed covariates. This requires that investigators proceed cautiously, as imbalance in key (nonlinear transformations of) covariates potentially introduces bias into the ultimate estimated effect. This paper introduces Targeted Function Balancing (TFB), a flexible covariate balancing weights approach…

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Comparing multilevel and fixed effect approaches in the generalized linear model setting

广义线性模型中多层模型与固定效应方法的比较

We extend prior work comparing linear multilevel models (MLM) and fixed effect (FE) models to the generalized linear model (GLM) setting, where the coefficient on a treatment variable is of primary interest. This leads to three insights. (i) First, as in the linear setting, MLM can be thought of as a regularized form of FE (RegFE). This explains why group-level confounding can greatly bias MLM's treatment coefficient estimates. However, unlike the linear setting, there is…

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A Smoothed Discrepancy Principle for Random Feature Methods and Neural Networks

随机特征方法与神经网络的平滑差异原则

We study data-driven early stopping for spectral regularisation methods in the classical non-parametric regression setting. Building on the discrepancy principle, we propose a multi-scale stopping rule that applies to general kernel estimators and show that, unlike previous approaches, it achieves full adaptivity over all smoothness levels in the well-specified case. A key contribution of our work is an extension based on random feature approximations, which reduces…

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Conditional Independence Testing in Time Series

时间序列中的条件独立检验

We consider the problem of testing Granger causality in time series, specifically, whether the future outcome $Y_{t+1}$ and the exposure history $\bar X_t$ are conditionally independent given the history of $\bar Y_t$ and a set of confounding variables $\bar Z_t$ up to time $t$. This testing procedure distinguishes true causal effects from associations driven by common external processes, supporting reliable decision-makings in applications such as finance, neuroscience, and…

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History-Conditioned Inference of Memory and Stochastic Forcing in Generalized Langevin Equations under Lévy Noise

Lévy 噪声下广义朗之万方程的历史条件化记忆与随机驱动推断

We consider the identification of memory and stochastic forcing in a one-dimensional generalized Langevin equation with state-dependent Brownian noise and optional additive symmetric $α$-stable jumps. A finite-dimensional Markov embedding provides Kramers--Moyal conditional moment relations that separate memory drift, Brownian diffusion, and jump contributions. From increment ensembles conditioned on the observed velocity history, truncated statistics estimate the stable…

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Epidemiological Causal Graph Identification: Challenges, Identifiability and Algorithms

流行病学因果图识别:挑战、可识别性与算法

Causal discovery from observational data is fundamental to statistics and machine learning, yet determining causal direction without interventions necessitates structural assumptions. Existing identifiability research primarily focuses on continuous variables under additive noise models, often neglecting mixed datasets containing ordinal scales, counts, and continuous measurements. This paper investigates causal discovery in Directed Acyclic Graphs (DAGs) where nodes follow…

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Beyond Linearity: Semiparametric Solutions to Contamination Bias with Multi-valued Treatments

超越线性:多值处理污染偏误的半参数解决方案

We examine semiparametric solutions to contamination bias for nonbinary treatments. Deepening the discussion by Goldsmith-Pinkham et al. (2024), we detail how spline functions approximate conditional expectation and propensity score functions under weak functional-form assumptions. Reanalyzing 18 regressions across 11 studies, we compare standard linear regressions against parametric and semiparametric versions of three contamination-robust estimators. We document large…

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Cosine metric as a structural economic similarity measure

作为经济结构相似性指标的余弦度量

Structural similarity, the extent to which economic mechanisms respond alike to common shocks, matters for economic forecasting, policy transfer, and other decisions that rely on evidence from comparable settings. For mechanisms approximated by linear models, this idea has a simple geometric representation: The smaller the angle between their coefficient vectors, the more similarly they respond to the same shock. This paper introduces the cosine of this angle as a measure of…

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Gaussian Boundary Inference in a Hypergeometric Heavy-Tailed Family

超几何重尾分布族中的高斯边界推断

This paper develops inference for a Gaussian-nested hypergeometric family of distribution functions. The family \[ G_c(z) = \frac12 + z\,\frac{Γ(c-1/2)}{2\sqrt2\,Γ(c)}\,{}_1F_1\!\left(\frac12;c;-\frac{z^2}{2}\right),\quad c\ge\frac32, \] contains the standard normal distribution at the boundary $c=3/2$. Away from the boundary, the density has algebraic tail behaviour $g_c(z)\sim(c-3/2)|z|^{-3}$, so the parameter $c$ indexes a directed heavy-tailed deformation of the Gaussian…

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Exponential Smoothing for Time Series of Random Objects

随机对象时间序列的指数平滑

Time series of random objects, such as covariance matrices, probability distributions, and functional data, call for forecasting methods that do not rely on standard arithmetic operations. We introduce geodesic exponential smoothing, a generalization of exponential smoothing to time series in Hadamard spaces: the forecast level moves a fixed fraction of the way along the geodesic toward each new observation. The smoothing parameter is estimated by minimizing the average…

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Nonlinear Probabilistic Forecast Reconciliation

非线性概率预测协调

Forecast reconciliation adjusts independently generated forecasts across multiple time series so that they satisfy some known constraints. While probabilistic forecast reconciliation is well established for linear constraints, some practical forecasting problems involve nonlinear relationships among time series. In this paper, we address probabilistic forecast reconciliation with nonlinear constraints for the first time. We extend both reconciliation via projection and…

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Identification and Estimation of Causal Estimands with Missing Not at Random Data

非随机缺失数据下因果目标量的识别与估计

Missing not at random (MNAR) data pose significant challenges for causal inference, particularly when both confounders and the outcome are partially observed. Without additional assumptions beyond those required for causal inference, causal estimands are generally not identifiable under MNAR mechanisms. This paper first develops identification results for the causal estimand, the average treatment effect, under several plausible MNAR mechanisms using completeness conditions,…

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A flexible approach to sequential prediction under intervention

干预下序贯预测的灵活方法

We propose a causal predictive framework for estimating risk under preventative interventions. The Unexposed Mediator Model maintains mediators that are also predictors at their unexposed level, removing double counting of intervention effects at followup visits. The Modifiable Risk Factor Model handles multiple interventions flexibly by modelling their effects via mediators that are also predictors, assuming a known causal structure. The Two Component Model combines a…

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