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元回归方法评估：地点与时间异质性的模拟研究AI 解读

In this paper, we conduct a simulation study with subject-level data to evaluate conventional meta-regression approaches (study-level random, fixed, and mixed effects) against seven methodology specifications new to meta-regressions that control joint heterogeneity in location and time (including a new one that we introduce). We systematically vary heterogeneity levels to assess statistical power, estimator bias and model robustness for each methodology specification. This…

For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed to be sparse segment-wise, which enables many existing methods to estimate the parameters locally via $\ell_1$-regularised maximum likelihood-type estimation and then contrast them for change point detection. Contrary to this common practice, we show that the exact sparsity of neither regression parameters nor their differences, a.k.a.\ differential parameters,…

高频金融数据的同步化AI 解读

Asynchronous trading in high-frequency financial markets introduces significant biases into econometric analysis, distorting risk estimates and leading to suboptimal portfolio decisions. Existing synchronization methods, such as the previous-tick approach, suffer from information loss and create artificial price staleness. We introduce a novel framework that recasts the data synchronization challenge as a constrained matrix completion problem. Our approach recovers the…

只试验一次：机器学习模型更新的持续因果验证AI 解读

Machine learning (ML) models are increasingly used as decision-support tools in high-risk domains. Evaluating the causal impact of deploying such models can be done with a randomized controlled trial (RCT) that randomizes users to ML vs. control groups and assesses the effect on relevant outcomes. However, ML models are inevitably updated over time, and we often lack evidence for the causal impact of these updates. While the causal effect could be repeatedly validated with…

生命表死亡人数年龄分布的自助预测区间AI 解读

We introduce a nonparametric bootstrap procedure based on a dynamic factor model to construct pointwise prediction intervals for period life-table death counts. The age distribution of death counts is an example of constrained data, which are nonnegative and have a constrained integral. A centered log-ratio transformation is used to remove the constraints. With a time series of unconstrained data, we introduce our bootstrap method to construct prediction intervals, thereby…

正则化 k-POD：面向高维缺失数据的稀疏 k-means 聚类AI 解读

The classical k-means clustering, based on distances computed from all data features, cannot be directly applied to incomplete data with missing values. A natural extension of k-means to missing data, namely k-POD, uses only the observed entries for clustering and is both computationally efficient and flexible. However, for high-dimensional missing data including features irrelevant to the underlying cluster structure, the presence of such irrelevant features leads to the…

事件时间结局自适应临床试验设计的一般贝叶斯方法AI 解读

Clinical trials are an integral component of medical research. Trials require careful design to, for example, maintain the safety of participants, use resources efficiently and allow clinically meaningful conclusions to be drawn. Adaptive clinical trials (i.e. trials that can be altered based on evidence that has accrued) are often more efficient, informative and ethical than standard or non-adaptive trials because they require fewer participants, target more promising…

包含新处理选项的政策学习AI 解读

I study the problem of a decision maker choosing a policy which allocates treatment to a heterogeneous population on the basis of experimental data that includes only a subset of possible treatment values. The effects of new treatments are partially identified by shape restrictions on treatment response. Policies are compared according to the minimax regret criterion, and I show that the empirical analog of the population decision problem has a tractable linear- and…

保险数据惩罚回归模型的系数区间估计AI 解读

The Tweedie exponential dispersion family is a popular choice among many to model insurance losses that consist of zero-inflated semicontinuous data. In such data, it is often important to obtain credibility (inference) of the most important features that describe the endogenous variables. Post-selection inference is the standard procedure in statistics to obtain confidence intervals of model parameters after performing a feature extraction procedure. For a linear model, the…

构造目标最小损失／最大似然估计量：建立直觉的简单示例AI 解读

Use of machine learning to estimate nuisance functions (e.g. outcomes models, propensity score models) in estimators used in causal inference is increasingly common, as it can mitigate bias due to model misspecification. However, it can be challenging to achieve valid inference (e.g., estimate valid confidence intervals). The efficient influence function (EIF) provides a recipe to go from a statistical estimand relevant to our causal question, to an estimator that can…

非线性世界中的动态因果效应：稳健解释与识别隐患AI 解读

Applied macroeconomists frequently use impulse response estimators motivated by linear models. We study whether the estimands of such procedures have a causal interpretation when the true data generating process is in fact nonlinear. We show that vector autoregressions and linear local projections onto observed shocks or proxies identify weighted averages of causal effects regardless of the extent of nonlinearities. By contrast, identification approaches that exploit…

慢性肾病分层复合终点分析中胜率比的解释难题AI 解读

Win statistics based methods have gained traction as a method for analyzing Hierarchical Composite Endpoints (HCEs) in randomized clinical trials, particularly in cardiovascular and kidney disease research. HCEs offer several key advantages, including increased statistical power, mitigation of competing risks, and hierarchical ranking of clinical outcomes. While, as summary measures, the win ratio (WR) along with the Net Benefit (NB) and the Win Odds (WO) provide a…

INAR模型系数与创新分布的联合半参数自助推断AI 解读

For modeling the serial dependence in time series of counts, various approaches have been proposed in the literature. In particular, models based on a recursive, autoregressive-type structure such as the well-known integer-valued autoregressive (INAR) models are very popular in practice. The distribution of such INAR models is fully determined by a vector of autoregressive binomial thinning coefficients and the discrete innovation distribution. While fully parametric…

双重差分中组别—时期条件平均处理效应的双重稳健一致置信带AI 解读

We consider a panel data analysis to examine the heterogeneity in treatment effects with respect to groups, periods, and a pre-treatment covariate of interest in the staggered difference-in-differences setting of Callaway and Sant'Anna (2021). Under standard identification conditions, a doubly robust estimand conditional on the covariate identifies the group-time conditional average treatment effect given the covariate. Focusing on the case of a continuous covariate, we…

Nullstrap：面向多样高维模型变量选择的FDR控制框架AI 解读

Balancing false discovery rate (FDR) control with high statistical power remains a central challenge in high-dimensional variable selection. While several FDR-controlling methods have been proposed, many degrade the original data -- by adding knockoff variables or splitting the data -- which often leads to substantial power loss and hampers detection of true signals. We introduce Nullstrap, a novel framework that controls FDR without altering the original data. Nullstrap…

误设定高维回归中非稀疏载荷的去偏预测推断AI 解读

High-dimensional regression models with regularized sparse estimation are widely applied. For statistical inferences, debiased methods are available about single coefficients or predictions with sparse new covariate vectors (also called loadings), in the presence of possible model misspecification. However, statistical inferences about predictions with non-sparse loadings are studied only under the assumption of correctly specified models. In this work, we develop debiased…

含互不相交反馈环的线性非高斯模型因果发现AI 解读

The paradigm of linear structural equation modeling readily allows one to incorporate causal feedback loops in the model specification. These appear as directed cycles in the common graphical representation of the models. However, the presence of cycles entails difficulties such as the fact that models need no longer be characterized by conditional independence relations. As a result, learning cyclic causal structures remains a challenging problem. In this paper, we offer…

高维多研究、多模态协变量增强广义因子模型AI 解读

Latent factor models that integrate data from multiple sources/studies or modalities have garnered considerable attention across various disciplines. However, existing methods predominantly focus either on multi-study integration or multi-modality integration, rendering them insufficient for analyzing the diverse modalities measured across multiple studies. To address this limitation and cater to practical needs, we introduce a high-dimensional generalized factor model that…

允许未知异方差或工具变量的高维二元选择模型AI 解读

This paper proposes a new method for estimating high-dimensional binary choice models. We consider a semiparametric model that places no distributional assumptions on the error term, allows for heteroskedastic errors, and permits endogenous regressors. Our approaches extend the special regressor estimator originally proposed by Lewbel (2000). This estimator becomes impractical in high-dimensional settings due to the curse of dimensionality associated with high-dimensional…

利用修正向量值处理政策分析机械通气参数的效应AI 解读

Mechanical ventilation is critical for managing respiratory failure, but inappropriate ventilator settings can lead to ventilator-induced lung injury (VILI), increasing patient morbidity and mortality. Evaluating the causal impact of ventilator settings is challenging due to the complex interplay of multiple treatment variables and strong confounding due to ventilator guidelines. In this paper, we propose a modified vector-valued treatment policy (MVTP) framework coupled…

连接结构因果推断与机器学习：异质性处理效应的 S-DIDML 估计量AI 解读

In response to the increasing complexity of policy environments and the proliferation of high-dimensional data, this paper introduces the S-DIDML estimator a framework grounded in structure and semiparametrically flexible for causal inference. By embedding Difference-in-Differences (DID) logic within a Double Machine Learning (DML) architecture, the S-DIDML approach combines the strengths of temporal identification, machine learning-based nuisance adjustment, and…

识别处理效应较高且可解释的子群体的算法AI 解读

We introduce an algorithm for identifying interpretable subgroups with elevated treatment effects, given an estimate of individual or conditional average treatment effects (CATE). Subgroups are characterized by ``rule sets'' -- easy-to-understand statements of the form (Condition A AND Condition B) OR (Condition C) -- which can capture high-order interactions while retaining interpretability. Our method complements existing approaches for estimating the CATE, which often…

带自适应异常值检测的稳健时空流行病建模AI 解读

In epidemic modeling, outliers can distort parameter estimation and ultimately lead to misguided public health decisions. Although there are existing robust methods that can mitigate this distortion, the ability to simultaneously detect outliers is equally vital for identifying potential disease hotspots. In this work, we introduce a robust spatiotemporal generalized additive model (RST-GAM) to address this need. We accomplish this with a mean-shift parameter to quantify and…

两级 SLOPE 在高维推断中的尖锐权衡AI 解读

Among techniques for high-dimensional linear regression, Sorted L-One Penalized Estimation (SLOPE) generalizes the LASSO via an adaptive $l_1$ regularization that applies heavier penalties to larger coefficients in the model. To achieve such adaptivity, SLOPE requires the specification of a complex hierarchy of penalties, i.e., a monotone penalty sequence in $R^p$, in contrast to a single penalty scalar for LASSO. Tuning this sequence when $p$ is large poses a challenge, as…