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Bayesian Inference for Confounding Variables and Limited Information

混杂变量与有限信息下的贝叶斯推断

A central challenge in statistical inference is the presence of confounding variables that may distort observed associations between treatment and outcome. Conventional "causal" methods, grounded in assumptions such as ignorability, exclude the possibility of unobserved confounders, leading to posterior inferences that overstate certainty. We develop a Bayesian framework that relaxes these assumptions by introducing entropy-favoring priors over hypothesis spaces that…

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Robust Functional Data Analysis for Stochastic Evolution Equations in Infinite Dimensions

无限维随机演化方程的稳健函数型数据分析

We develop an asymptotic theory for the jump robust measurement of covariations in the context of stochastic evolution equation in infinite dimensions. Namely, we identify scaling limits for realized covariations of solution processes with the quadratic covariation of the latent random process that drives the evolution equation which is assumed to be a Hilbert space-valued semimartingale. We discuss applications to dynamically consistent and outlier-robust dimension…

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Optimal Shrinkage Estimation of Fixed Effects in Linear Panel Data Models

线性面板数据模型中固定效应的最优收缩估计

Shrinkage methods are frequently used to improve the precision of least squares estimators of fixed effects. However, widely used shrinkage estimators guarantee improved precision only under strong distributional assumptions. I develop an estimator for the fixed effects that obtains the best possible mean squared error within a class of shrinkage estimators. This class includes conventional shrinkage estimators and the optimality does not require distributional assumptions.…

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Inferring Change Points in High-Dimensional Regression via Approximate Message Passing

高维回归中变点的近似消息传递推断

We consider the problem of localizing change points in a generalized linear model (GLM), a model that covers many widely studied problems in statistical learning including linear, logistic, and rectified linear regression. We propose a novel and computationally efficient Approximate Message Passing (AMP) algorithm for estimating both the signals and the change point locations, and rigorously characterize its performance in the high-dimensional limit where the number of…

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Nonparametric estimation of the Patient Weighted While-Alive Estimand

患者加权存活期间估计目标的非参数估计

In clinical trials with recurrent events, such as repeated hospitalizations terminating with death, it is important to consider the patient events overall history for a thorough assessment of treatment effects. The occurrence of fewer events due to early deaths can lead to misinterpretation, emphasizing the importance of a while-alive strategy as suggested in Schmidli et al. (2023). In this study, we focus on the patient weighted while-alive estimand, represented as the…

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Treatment Effects of Multi-Valued Treatments in Hyper-Rectangle Model

超矩形模型中多值处理的处理效应

This study investigates the identification of marginal treatment responses within multi-valued treatment models. Extending the hyper-rectangle model introduced by Lee and Salanie (2018), this paper relaxes restrictive assumptions, including the requirement of known treatment selection thresholds and the dependence of treatments on all unobserved heterogeneity. By incorporating an additional ranked treatment assumption, this study demonstrates that the marginal treatment…

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Tail-robust factor modelling of vector and tensor time series in high dimensions

高维向量与张量时间序列的重尾稳健因子建模

We study the problem of factor modelling vector- and tensor-valued time series in the presence of heavy tails in the data, which produce extreme observations with non-negligible probability. We propose to combine a two-step procedure for tensor decomposition with data truncation, which is easy to implement and does not require an iterative search for a numerical solution. Departing away from the light-tail assumptions often adopted in the time series factor modelling…

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Semi-supervised inference for treatment heterogeneity

处理效应异质性的半监督推断

In causal inference, measuring treatment heterogeneity is crucial as it provides scientific insights into how treatments influence outcomes and guides personalized decision-making. In this work, we study semi-supervised settings where a labeled dataset is accompanied by a large unlabeled dataset, and develop semi-supervised estimators for two measures of treatment heterogeneity: the total treatment heterogeneity (TTH) and the explained treatment heterogeneity (ETH) of a…

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Optimal Estimation for General Gaussian Processes

一般高斯过程的最优估计

This paper proposes a novel exact maximum likelihood (ML) estimation method for general Gaussian processes, where all parameters are estimated jointly. The exact ML estimator (MLE) is consistent and asymptotically normally distributed. We prove the local asymptotic normality (LAN) property of the sequence of statistical experiments for general Gaussian processes in the sense of Le Cam, thereby enabling optimal estimation and facilitating statistical inference. The results…

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A Bayesian Gaussian Process Dynamic Factor Model

贝叶斯高斯过程动态因子模型

We propose a dynamic factor model (DFM) where the latent factors are linked to observed variables with unknown and potentially nonlinear functions. The key novelty and source of flexibility of our approach is a nonparametric observation equation, specified via Gaussian Process (GP) priors for each series. Factor dynamics are modeled with a standard vector autoregression (VAR), which facilitates computation and interpretation. We discuss a computationally efficient estimation…

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A Latent Class Bayesian Model for Multivariate Longitudinal Outcomes with Excess Zeros

含超额零值的多变量纵向结果的潜类别贝叶斯模型

Latent class models have been successfully used to handle complex datasets in different disciplines. For longitudinal outcomes, we often get a trajectory of the outcome for each individual, and on that basis, we cluster them for a powerful statistical inference. Latent class models have been used to handle multivariate longitudinal outcomes coming from biology, health sciences, and economics. In this paper, we propose a Bayesian latent class model for multivariate outcomes…

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Strong Consistency of the SIMEX Estimator in Linear Regression with a Conditionally Poisson Covariate

条件泊松协变量线性回归中 SIMEX 估计量的强相合性

This paper considers estimation for linear regression analysis with covariate measurement error arising from Poisson surrogates. We consider cases where covariates follow a conditional Poisson distribution, capturing non-Gaussian and heteroscedastic error structures. To address this, we extend the simulation extrapolation (SIMEX) algorithm to the conditional Poisson setting (POI-SIMEX), enabling robust adjustment in the absence of internal validation data. Theoretical…

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Applying non-negative matrix factorization with covariates to multivariate time series data as a vector autoregression model

将含协变量的非负矩阵分解与向量自回归结合分析多变量时间序列

We propose a novel framework for analyzing multivariate time series (MTS) data by integrating non-negative matrix factorization (NMF) with vector autoregression (VAR). Termed NMF-VAR, this method models the coefficient matrix of NMF as a VAR process, enabling simultaneous extraction of latent components and temporal dependencies. Unlike standard VAR, which struggles with high dimensionality and lacks clarity, our method introduces a low-rank latent structure that reduces the…

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Precision Mental Health: Predicting Heterogeneous Treatment Effects for Depression through Data Integration

精准精神健康:通过数据整合预测抑郁症的异质性处理效应

When treating depression, clinicians are interested in determining the optimal treatment for a given patient, which is challenging given the amount of treatments available. To advance individualized treatment allocation, integrating data across multiple randomized controlled trials (RCTs) can enhance our understanding of treatment effect heterogeneity by increasing available information. However, extending these inferences to individuals outside of the original RCTs remains…

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An Interpretable Ensemble Framework for Multi-Omics Dementia Biomarker Discovery Under HDLSS Conditions

HDLSS条件下多组学痴呆生物标志物发现的可解释集成框架

Biomarker discovery in neurodegenerative diseases requires robust, interpretable frameworks capable of integrating high-dimensional multi-omics data under low-sample conditions. We propose a novel ensemble approach combining Graph Attention Networks (GAT), MultiOmics Variational AutoEncoder (MOVE), Elastic-net sparse regression, and Storey's False Discovery Rate (FDR). This framework is benchmarked against state-of-the-art methods including DIABLO, MOCAT, AMOGEL, and MOMLIN.…

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Consumer Welfare Under Individual Heterogeneity

个体异质性下的消费者福利

We propose a nonparametric method for estimating the distribution of consumer welfare from cross-sectional data with no restrictions on individual preferences. First demonstrating that moments of demand identify the curvature of the expenditure function, we use these moments to approximate money-metric welfare measures. Our approach captures both nonhomotheticity and heterogeneity in preferences in the behavioral responses to price changes. We apply our method to US…

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Reduce-Rank Matrix Integer-Valued Autoregressive Model

降秩矩阵整数值自回归模型

Integer-valued time series are widely present in many fields, such as finance, economics, disease transmission, and traffic flow. With data dimensions surging, the traditional multivariate generalized integer autoregressive (MGINAR) model faces parameter overload, poor interpretability, and structural information loss. Matrix integer-valued autoregression (MINAR) model captures row-column cross-correlations and reduces the number of parameters to be estimated. However,…

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Estimation of High-Dimensional Markov-Switching VAR Models with an Approximate EM Algorithm

利用近似EM算法估计高维马尔可夫切换VAR模型

Regime shifts in high-dimensional time series arise naturally in many applications, from neuroimaging to finance. This problem has received considerable attention in low-dimensional settings, with both Bayesian and frequentist methods used extensively for parameter estimation. The EM algorithm is a particularly popular strategy for parameter estimation in low-dimensional settings, although the statistical properties of the resulting estimates have not been well understood.…

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An integrated method for clustering and association network inference

聚类与关联网络推断的整合方法

High dimensional Gaussian graphical models provide a rigorous framework to describe a network of statistical dependencies between entities, such as genes in genomic regulation studies or species in ecology. Penalized methods, including the standard Graphical-Lasso, are well-known approaches to infer the parameters of these models. As the number of variables in the model (of entities in the network) grow, the network inference and interpretation become more complex. The…

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Evaluation of Stress Detection as Time Series Events -- A Novel Window-Based F1-Metric

将压力检测视为时间序列事件:一种窗口式F1指标

Accurate evaluation of event detection in time series is essential for applications such as stress monitoring with wearable devices, where ground truth is typically annotated as single-point events, even though the underlying phenomena are gradual and temporally diffused. Standard metrics like F1 and point-adjusted F1 (F1$_{pa}$) often misrepresent model performance in such real-world, imbalanced datasets. We introduce a window-based F1 metric (F1$_w$) that incorporates…

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Data driven modeling of multiple interest rates with generalized Vasicek-type models

广义Vasicek型模型下多利率的数据驱动建模

The Vasicek model is a commonly used interest rate model, and there exist many extensions and generalizations of it. However, most generalizations of the model are either univariate or assume the noise process to be Gaussian, or both. In this article, we study a generalized multivariate Vasicek model that allows simultaneous modeling of multiple interest rates while making minimal assumptions. In the model, we only assume that the noise process has stationary increments with…

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Bayesian Network Propensity Score to Evaluate Treatment Effects in Observational Studies

用于观察性研究处理效应评估的贝叶斯网络倾向得分

This paper focuses on the Bayesian Network Propensity Score (BNPS), a novel approach for estimating treatment effects in observational studies characterized by unknown (and likely unbalanced) designs and complex dependency structures among covariates. Traditional methods, such as logistic regression, often impose rigid parametric assumptions that may lead to misspecification errors, compromising causal inference. Recent classical and machine learning alternatives, such as…

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Learning sparse generalized linear models with binary outcomes via iterative hard thresholding

基于迭代硬阈值的学习二元结果稀疏广义线性模型

In statistics, generalized linear models (GLMs) are widely used for modeling data and can expressively capture potential nonlinear dependence of the model's outcomes on its covariates. Within the broad family of GLMs, those with binary outcomes, which include logistic and probit regressions, are motivated by common tasks such as binary classification with (possibly) non-separable data. In addition, in modern machine learning and statistics, data is often high-dimensional yet…

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Distal Causal Excursion Effects: Modeling Long-Term Effects of Time-Varying Treatments in Micro-Randomized Trials

远期因果偏离效应:微随机试验中时变处理的长期效应建模

Micro-randomized trials (MRTs) play a crucial role in optimizing digital interventions. In an MRT, each participant is sequentially randomized among treatment options hundreds of times. While the interventions tested in MRTs target short-term behavioral responses (proximal outcomes), their ultimate goal is to drive long-term behavior change (distal outcomes). However, existing causal inference methods, such as the causal excursion effect, are limited to proximal outcomes,…

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