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Bayesian Semiparametric Causal Inference: Targeted Doubly Robust Estimation of Treatment Effects

贝叶斯半参数因果推断:处理效应的目标化双重稳健估计

We propose a semiparametric Bayesian methodology for estimating the average treatment effect (ATE) within the potential outcomes framework using observational data with high-dimensional nuisance parameters. Our method introduces a Bayesian debiasing procedure that corrects for bias arising from nuisance estimation and employs a targeted modeling strategy based on summary statistics rather than the full data. These summary statistics are identified in a debiased manner,…

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Cross-Balancing for Data-Informed Design and Efficient Analysis of Observational Studies

交叉平衡:利用数据设计并高效分析观察研究

Causal inference starts with a simple idea: compare groups that differ by treatment, not much else. Traditionally, similar groups are constructed using only observed covariates; however, it remains a long-standing challenge to incorporate available outcome data into the study design while preserving valid inference. In this paper, we study the general problem of covariate adjustment, effect estimation, and statistical inference when balancing features are constructed or…

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Causal Inference on Sequential Treatments via Tensor Completion

通过张量补全推断序贯处理的因果效应

Marginal Structural Models (MSMs) are popular for causal inference of sequential treatments in longitudinal observational studies, which however are sensitive to model misspecification. To achieve flexible modeling, we envision the potential outcomes to form a three-dimensional tensor indexed by subject, time, and treatment regime and propose a tensorized history-restricted MSM (HRMSM). The semi-parametric tensor factor model allows us to leverage the underlying low-rank…

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On robust Bayesian causal inference

稳健贝叶斯因果推断

This paper develops a Bayesian framework for robust causal inference from longitudinal observational data. Many contemporary methods rely on structural assumptions, such as factor models, to adjust for unobserved confounding, but they can lead to biased causal estimands when mis-specified. We focus on directly estimating time--unit--specific causal effects and use generalised Bayesian inference to quantify model mis-specification and adjust for it, while retaining…

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Exponential Lasso: robust sparse penalization under heavy-tailed noise and outliers with exponential-type loss

指数 Lasso:重尾噪声与离群点下的稳健稀疏惩罚

In high-dimensional statistics, the Lasso is a cornerstone method for simultaneous variable selection and parameter estimation. However, its reliance on the squared loss function renders it highly sensitive to outliers and heavy-tailed noise, potentially leading to unreliable model selection and biased estimates. To address this limitation, we introduce the Exponential Lasso, a novel robust method that integrates an exponential-type loss function within the Lasso framework.…

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BaGGLS: A Bayesian Shrinkage Framework for Interpretable Modeling of Interactions in High-Dimensional Biological Data

BaGGLS:高维生物数据交互可解释建模的贝叶斯收缩框架

Biological data sets are often high-dimensional, noisy, and governed by complex interactions among sparse signals. This poses major challenges for interpretability and reliable feature selection. Tasks such as identifying motif interactions in genomics exemplify these difficulties, as only a small subset of biologically relevant features (e.g., motifs) are typically active, and their effects are often non-linear and context-dependent. While statistical approaches often…

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Consistent Group selection using Global-local prior in High dimensional setup

高维分组模型选择中的全局-局部先验一致性方法

We consider the problem of model selection when grouping structure is inherent within the regressors. Using a Bayesian approach, we model the mean vector by a one-group global-local shrinkage prior belonging to a broad class of such priors that includes the horseshoe prior. In the context of variable selection, this class of priors was studied by Tang et al. (2018). A modified form of the usual class of global-local shrinkage priors with polynomial tail on the group…

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Testing relevant difference in high-dimensional linear regression with applications to detect transferability

高维线性回归中相关差异检验及其在迁移性检测中的应用

Most of researchers on testing a significance of coefficient $\ubeta$ in high-dimensional linear regression models consider the classical hypothesis testing problem $H_0^{c}: \ubeta=\uzero \mbox{ versus } H_1^{c}: \ubeta \neq \uzero$. We take a different perspective and study the testing problem with the null hypothesis of no relevant difference between $\ubeta$ and $\uzero$, that is, $H_0: \|\ubeta\|\leq δ_0 \mbox{ versus } H_1: \|\ubeta\|> δ_0$, where $δ_0$ is a…

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A new non-parametric Kendall's tau for matrix-valued elliptical observations

矩阵值椭圆分布观测的新非参数 Kendall 秩相关方法

In this article, we first propose generalized row/column matrix Kendall's tau for matrix-variate observations that are ubiquitous in areas such as finance and medical imaging. For a random matrix following a matrix-variate elliptically contoured distribution, we show that the eigenspaces of the proposed row/column matrix Kendall's tau coincide with those of the row/column scatter matrix respectively, with the same descending order of the eigenvalues. We perform eigenvalue…

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Causal Inference in Financial Event Studies

金融事件研究中的因果推断

Financial event studies, ubiquitous in finance research, typically use linear factor models with known factors to estimate abnormal returns and identify causal effects of information events. This paper demonstrates that when factor models are misspecified -- an almost certain reality -- traditional event study estimators produce inconsistent estimates of treatment effects. The bias is particularly severe during volatile periods, over long horizons, and when event timing…

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Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial

利用疫苗无关感染去偏随时间变化的风险率型疫苗效应

Understanding how vaccine effectiveness (VE) changes over time can provide evidence-based guidance for public health decision making. While commonly reported by practitioners, time-varying VE estimates obtained using Cox regression are vul- nerable to hidden biases. To address these limitations, we describe how to leverage vaccine-irrelevant infections to identify hazard-based, time-varying VE in the pres- ence of unmeasured confounding and selection bias. We articulate…

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Individualized Prediction Bands in Causal Inference with Continuous Treatments

连续处理因果推断中的个体化预测带

Individualized treatments are crucial for optimal decision making and treatment allocation, specifically in personalized medicine based on the estimation of an individual's dose-response curve across a continuum of treatment levels, e.g., drug dosage. Current works focus on conditional mean and median estimates, which are useful but do not provide the full picture. We propose viewing causal inference with a continuous treatment as a covariate shift. This allows us to…

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Regression adjustment in completely randomized experiments with many covariates

多协变量完全随机实验中的回归调整

This paper investigates estimation and inference for average treatment effects in completely randomized experiments when researchers observe potentially many covariates. Within Neyman's (1923) design-based framework, allowing the number of covariates to grow more slowly than the sample size, we demonstrate that a cross-fitted regression adjustment estimator--adapted from Aronow and Middleton (2013)--exhibits more favorable asymptotic properties than existing alternatives,…

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On the Identifying Power of Generalized Monotonicity for Average Treatment Effects

广义单调性对平均处理效应的识别能力

In the context of a binary outcome, treatment, and instrument, Balke and Pearl (1993, 1997) es- tablish that the monotonicity condition of Imbens and Angrist (1994) has no identifying power beyond instrument exogeneity for average potential outcomes and average treatment effects in the sense that adding it to instrument exogeneity does not decrease the identified sets for those parameters whenever those restrictions are consistent with the distribution of the observable…

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Estimation of Latent Group Structures in Time-Varying Panel Data Models

时变面板数据模型中潜在分组结构的估计

We consider panel data models where coefficients change smoothly over time and follow a latent group structure, being homogeneous within but heterogeneous across groups. To jointly estimate the group membership and group-specific coefficient trajectories, we propose FUSE-TIME, a pairwise adaptive group fused-Lasso estimator combined with polynomial spline sieves. We establish consistency, derive the asymptotic distributions of the penalized sieve estimator and its…

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Minimax Analysis of Estimation Problems in Coherent Imaging

相干成像中估计问题的极小极大分析

Unlike conventional imaging modalities, such as magnetic resonance imaging, which are often well described by a linear regression framework, coherent imaging systems follow a significantly more complex model. In these systems, the task is to estimate the unknown image ${\boldsymbol x}_o \in \mathbb{R}^n$ from observations ${\boldsymbol y}_1, \ldots, {\boldsymbol y}_L \in \mathbb{R}^m$ of the form \[ {\boldsymbol y}_l = A_l X_o {\boldsymbol w}_l + {\boldsymbol z}_l, \quad l = 1, \ldots, L, \]…

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A Bayesian INLA-SPDE Approach to Spatio-Temporal Point-Grid Fusion with Change-of-Support and Misaligned Covariates

贝叶斯 INLA-SPDE 时空点-网格数据融合:支撑变化与协变量错位

We propose a spatio-temporal data-fusion framework for point data and gridded data with variables observed on different spatial supports. A latent Gaussian field with a Matérn-SPDE prior provides a continuous space representation, while source-specific observation operators map observations to both point measurements and gridded averages, addressing change-of-support and covariate misalignment. Additionally incorporating temporal dependence enables prediction at unknown…

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Detecting practically significant dependencies in metric spaces via distance correlations

利用距离相关检测度量空间中的实际显著依赖

We take a different look at the problem of testing the independence of two metric-space-valued random variables using the distance correlation. Instead of testing if the distance correlation vanishes exactly, we are interested in the hypothesis that it does not exceed a certain threshold. Our testing problem is motivated by the observation that in many cases it is more reasonable to test for a practically significant dependency since it is rare that a hypothesis of perfect…

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Covariate Adjustment in Randomized Experiments Motivated by Higher-Order Influence Functions

受高阶影响函数启发的随机实验协变量调整

Higher-Order Influence Functions (HOIF), developed in a series of papers over the past twenty years, are a fundamental theoretical device for constructing rate-optimal causal-effect estimators from observational studies. However, the value of HOIF for analyzing well-conducted randomized controlled trials (RCT) has not been explicitly explored. In the recent U.S. Food and Drug Administration and European Medicines Agency guidelines on the practice of covariate adjustment in…

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Transfer Learning and Locally Linear Regression for Locally Stationary Time Series

局部平稳时间序列的迁移学习与局部线性回归

This paper investigates locally linear regression for locally stationary time series and develops theoretical results for locally linear smoothing and transfer learning. Existing analyses have focused on local constant estimators and given samples, leaving the principles of transferring knowledge from auxiliary sources across heterogeneous time-varying domains insufficiently established. We derive uniform convergence for multivariate locally linear estimators under strong…

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A Two-step Estimating Approach for Heavy-tailed AR Models with Non-zero Median GARCH-type Noises

非零中位数 GARCH 型噪声下厚尾 AR 模型的两步估计

This paper develops a novel two-step estimating procedure for heavy-tailed AR models with non-zero median GARCH-type noises, allowing for time-varying volatility. We first establish the self-weighted quantile regression estimator (SQE) across all quantile levels $τ\in (0,1)$ for the AR parameters $θ_{0}$. We show that the SQE, less a bias, converges weakly to a Gaussian process at a rate of $n^{-1/2}$. The bias is zero if and only if $τ$ equals $τ_{0}$, the probability that…

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Synthetic Survival Control: Extending Synthetic Controls for "When-If" Decision

合成生存控制:面向事件发生时间反事实的合成控制扩展

Estimating causal effects on time-to-event outcomes from observational data is particularly challenging due to censoring, limited sample sizes, and non-random treatment assignment. The need for answering such "when-if" questions--how the timing of an event would change under a specified intervention--commonly arises in real-world settings with heterogeneous treatment adoption and confounding. To address these challenges, we propose Synthetic Survival Control (SSC) to…

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An Instrumental Variables Framework to Unite Spatial Confounding Methods

统一空间混杂处理方法的工具变量框架

Studies investigating the causal effects of spatially varying exposures on outcomes often rely on observational and spatially indexed data. A prevalent challenge is unmeasured spatial confounding, where an unobserved spatially varying variable affects both exposure and outcome, leading to biased estimates and invalid confidence intervals. There is a very large literature on spatial statistics that attempts to address unmeasured spatial confounding bias; most of this…

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Gradient descent inference in empirical risk minimization

经验风险最小化中的梯度下降推断

Gradient descent is one of the most widely used iterative algorithms in modern statistical learning. However, its precise algorithmic dynamics in high-dimensional settings remain only partially understood, which has limited its broader potential for statistical inference applications. This paper provides a precise, non-asymptotic joint distributional characterization of gradient descent iterates and their debiased statistics in a broad class of empirical risk minimization…

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