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Bayesian identification of early warning signals for long-range dependent climatic time series

长程相依气候时间序列早期预警信号的贝叶斯识别

Detecting early warning signals in climatic time series is essential for anticipating critical transitions and tipping points. Common statistical indicators include increased variance and lag-one autocorrelation prior to bifurcation points. However, these indicators are sensitive to observational noise, long-term mean trends, and long-memory dependence, all of which are prevalent in climatic time series. Such effects can easily obscure genuine signals or generate spurious…

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Variational autoencoder for inference of nonlinear mixed effect models based on ordinary differential equations

基于常微分方程的非线性混合效应模型的变分自编码器推断

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions, likelihood-based inference via the stochastic approximation EM algorithm (SAEM) is widely used, but it relies on Markov Chain Monte-Carlo (MCMC) to approximate subject-specific posteriors. As model complexity increases or observations per…

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Estimating Interventional Distributions with Uncertain Causal Graphs through Meta-Learning

通过元学习估计因果图不确定时的干预分布

In scientific domains -- from biology to the social sciences -- many questions boil down to \textit{What effect will we observe if we intervene on a particular variable?} If the causal relationships (e.g.~a causal graph) are known, it is possible to estimate the intervention distributions. In the absence of this domain knowledge, the causal structure must be discovered from the available observational data. However, observational data are often compatible with multiple…

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A joint QoL-Survival framework with debiased estimation under truncation by death

死亡截断下生活质量与生存的联合框架及去偏估计

Evaluating quality-of-life (QoL) outcomes in populations with high mortality risk is complicated by truncation by death, since QoL is undefined for individuals who do not survive to the planned measurement time. We propose a framework that jointly models the distribution of QoL and survival without extrapolating QoL beyond death. Inspired by multistate formulations, we extend the joint characterization of binary health states and mortality to continuous QoL outcomes. Because…

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Asymptotic Inference for Rank Correlations

秩相关系数的渐近推断

Kendall's tau and Spearman's rho are widely used tools for measuring dependence. Surprisingly, when it comes to asymptotic inference for these rank correlations, some fundamental results and methods have not yet been developed, in particular for discrete random variables and in the time series case, and concerning variance estimation in general. Consequently, asymptotic confidence intervals are not available. We provide a comprehensive treatment of asymptotic inference for…

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Holistic Multi-Scale Inference of the Leverage Effect: Efficiency under Dependent Microstructure Noise

杠杆效应的整体多尺度推断:相依微观结构噪声下的效率

This paper addresses the long-standing challenge of estimating the leverage effect from high-frequency data contaminated by dependent, non-Gaussian microstructure noise. We depart from the conventional reliance on pre-averaging or volatility "plug-in" methods by introducing a holistic multi-scale framework that operates directly on the leverage effect. We propose two novel estimators: the Subsampling-and-Averaging Leverage Effect (SALE) and the Multi-Scale Leverage Effect…

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Mapping Drivers of Greenness: Spatial Variable Selection for MODIS Vegetation Indices

植被绿度驱动因素的空间变量选择:面向 MODIS 植被指数

Understanding how environmental drivers relate to vegetation condition motivates spatially varying regression models, but estimating a separate coefficient surface for every predictor can yield noisy patterns and poor interpretability when many predictors are irrelevant. Motivated by MODIS vegetation index studies, we examine predictors from spectral bands, productivity and energy fluxes, observation geometry, and land surface characteristics. Because these relationships…

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Triply Robust Panel Estimators

三重稳健面板估计量

This paper studies estimation of causal effects in a panel data setting. We introduce a new estimator, the Triply RObust Panel (TROP) estimator, that combines (i) a flexible model for the potential outcomes based on a low-rank factor structure on top of a two-way-fixed effect specification, with (ii) unit weights intended to upweight units similar to the treated units and (iii) time weights intended to upweight time periods close to the treated time periods. We study the…

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Estimating causal effects of functional treatments with modified functional treatment policies

通过修正函数型处理策略估计函数型处理的因果效应

Functional data are increasingly prevalent in biomedical research. While functional data analysis has been established for decades, causal inference with functional treatments remains largely unexplored. Existing methods typically focus on estimating the causal average dose response functional (ADRF), which requires strong positivity assumptions and offers limited interpretability. In this work, we target a new causal estimand, the modified functional treatment policy…

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Bias-Targeted Nonparametric Balancing for Stable Causal Mediation Analysis

面向稳定因果中介分析的偏差针对性非参数平衡

Influence function (IF)-based estimators are widely used in mediation analysis due to their modeling flexibility, but standard implementations require direct estimation of the distribution functions of the mediator and treatment variables. Since these functions appear in the denominator of IF-based estimators, they can induce significant instability, particularly with continuous mediators. In this work, we propose an alternative implementation of IF-based estimators for both…

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Fixed Effects as Generated Regressors

作为生成回归变量的固定效应

Many economic models feature moment conditions that involve latent variables. When the latent variables are individual fixed effects in an auxiliary panel data regression, we construct orthogonal moments that eliminate first-order bias induced by estimating the fixed effects. Machine Learning methods and Empirical Bayes methods can be used to improve the estimate of the nuisance parameters in the orthogonal moments. We establish a central limit theorem based on the…

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Two-Stage Data Synthesization: A Statistics-Driven Restricted Trade-off between Privacy and Prediction

两阶段数据合成:隐私与预测之间由统计驱动的受限权衡

Synthetic data have gained increasing attention across various domains, with a growing emphasis on their performance in downstream prediction tasks. However, most existing synthesis strategies focus on maintaining statistical information. Although some studies address prediction performance guarantees, their single-stage synthesis designs make it challenging to balance the privacy requirements that necessitate significant perturbations and the prediction performance that is…

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Measures for Assessing Causal Effect Heterogeneity Unexplained by Covariates

评估协变量无法解释的因果效应异质性

There has been considerable interest in estimating heterogeneous causal effects across individuals or subpopulations. Researchers often assess causal effect heterogeneity based on the subjects' covariates using the conditional average causal effect (CACE). However, substantial heterogeneity may persist even after accounting for the covariates. Existing work on causal effect heterogeneity unexplained by covariates mainly focused on binary treatment and outcome. In this paper,…

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Empirical Bayes Variable Selection with Lasso Statistics in the AMP Framework

AMP框架下基于Lasso统计量的经验贝叶斯变量选择

The Lasso is one of the most ubiquitous methods for variable selection in high-dimensional linear regression and has been studied extensively under different regimes. In a particular asymptotic setup entailing $n/p\to \text{constant}$, an i.i.d.~Gaussian $X$ matrix and linear sparsity, \citet{su2017false} analyzed the Lasso selection path and presented negative results, showing that maintaining small levels of the false discovery proportion comes at a substantial cost in…

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Estimating the Value of Evidence-Based Decision Making

循证决策价值的估计

In an era of data abundance, statistical evidence is increasingly critical for business and policy decisions. Yet, organizations lack empirical tools to assess the value of evidence-based decision making (EBDM), optimize statistical precision, and balance the costs of evidence-gathering strategies against their benefits. To tackle these challenges, this article introduces an empirical framework to estimate the value of EBDM and evaluate the return on investment in…

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A Causal Machine Learning Framework for Treatment Personalization in Clinical Trials: Application to Ulcerative Colitis

临床试验治疗个性化的因果机器学习框架:溃疡性结肠炎应用

Randomized controlled trials estimate average treatment effects, but treatment response heterogeneity motivates personalized approaches. A critical question is whether statistically detectable heterogeneity translates into improved treatment decisions -- these are distinct questions that can yield contradictory answers. We present a modular causal machine learning framework that evaluates each question separately: permutation importance identifies which features predict…

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Sparsified-Learning for High-Dimensional Heavy-Tailed Locally Stationary Time Series, Concentration and Oracle Inequalities

高维重尾局部平稳时间序列的稀疏学习:集中与预言不等式

Sparse learning is ubiquitous in many machine learning tasks. It aims to regularize the goodness-of-fit objective by adding a penalty term to encode structural constraints on the model parameters. In this paper, we develop a flexible sparse learning framework tailored to high-dimensional heavy-tailed locally stationary time series (LSTS). The data-generating mechanism incorporates a regression function that changes smoothly over time and is observed under noise belonging to…

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Multivariate Causal Effects: a Bayesian Causal Regression Factor Model

多元因果效应:贝叶斯因果回归因子模型

The impact of wildfire smoke on air quality is a growing concern, contributing to air pollution through a complex mixture of chemical species with important implications for public health. While previous studies have primarily focused on its association with total particulate matter (PM2.5), the causal relationship between wildfire smoke and the chemical composition of PM2.5 remains largely unexplored. Exposure to these chemical mixtures plays a critical role in shaping…

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Identification and Estimation of Seller Risk Aversion in Ascending Auctions

升价拍卖中卖方风险厌恶的识别与估计

This paper shows how to identify and estimate the seller's risk parameter in an ascending auction. We consider a semiparametric model where the seller has a parametric utility function (such as CARA or CRRA) and the distribution of bidder valuations is modeled flexibly. We provide primitive conditions under which the risk parameter is identified and show that it can be consistently estimated with an asymptotically normal limiting distribution under standard regularity…

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Channel Estimation with Hierarchical Sparse Bayesian Learning for ODDM Systems

ODDM 系统中基于分层稀疏贝叶斯学习的信道估计

Orthogonal delay-Doppler division multiplexing (ODDM) is a promising modulation technique for reliable communications in high-mobility scenarios. However, the existing channel estimation frameworks for ODDM systems cannot achieve both high accuracy and low complexity simultaneously, due to the inherent coupling of delay and Doppler parameters. To address this problem, a two-dimensional (2D) hierarchical sparse Bayesian learning (HSBL) based channel estimation framework is…

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Hyperbolic statistical inference for Treatment Effects with Circular biomarker of astigmatism

圆形散光生物标志物治疗效应的双曲几何统计推断

Circular biomarkers arise naturally in many biomedical applications, particularly in ophthalmology, where angular measurements such as astigmatism are routinely recorded. Similar directional variables also occur in the study of human body rotations, including movements of the hand, waist, neck, and lower limbs. Motivated by a clinical dataset comprising angular measurements of astigmatism induced by two cataract surgery procedures, we propose a novel two-sample testing…

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Beating the Winner's Curse via Inference-Aware Policy Optimization

通过考虑推断的政策优化缓解赢家诅咒

There has been a surge of recent interest in automatically learning policies to target treatment decisions based on rich individual covariates. In addition, practitioners want confidence that the learned policy has better performance than the incumbent policy according to downstream policy evaluation. However, due to the winner's curse -- an issue where the policy optimization procedure exploits prediction errors rather than finding actual improvements -- predicted…

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Bayesian Shrinkage in High-Dimensional VAR Models: A Comparative Study

高维 VAR 模型中的贝叶斯收缩:比较研究

High-dimensional vector autoregressive (VAR) models offer a versatile framework for multivariate time series analysis, yet face critical challenges from over-parameterization and uncertain lag order. In this paper, we systematically compare three Bayesian shrinkage priors (horseshoe, lasso, and normal) and two frequentist regularization approaches (ridge and nonparametric shrinkage) under three carefully crafted simulation scenarios. These scenarios encompass (i) overfitting…

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Identification and Debiased Learning of Causal Effects with General Instrumental Variables

一般工具变量下因果效应的识别与去偏学习

Instrumental variable methods are fundamental to causal inference when treatment assignment is confounded by unobserved variables. In this article, we develop a general nonparametric causal framework for identification and learning with multi-categorical or continuous instrumental variables. Specifically, the mean potential outcomes and the average treatment effect can be identified via a regular weighting function derived from the proposed framework. Leveraging…

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