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A Guide to Regression Discontinuity Designs in Medical Applications

医学应用中的回归不连续设计指南

We present a practical guide for the analysis of regression discontinuity (RD) designs in biomedical contexts. We begin by introducing key concepts, assumptions, and estimands within both the continuity-based framework and the local randomization framework. We then discuss modern estimation and inference methods within both frameworks, including approaches for bandwidth or local neighborhood selection, optimal treatment effect point estimation, and robust bias-corrected…

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Efficient Semiparametric Estimation of Average Treatment Effects Under Covariate Adaptive Randomization

协变量自适应随机化下平均处理效应的半参数有效估计

Experiments that use covariate adaptive randomization (CAR) are commonplace in applied economics and other fields. In such experiments, the experimenter first stratifies the sample according to observed baseline covariates and then assigns treatment randomly within these strata so as to achieve balance according to pre-specified stratum-specific target assignment proportions. In this paper, we compute the semiparametric efficiency bound for estimating the average treatment…

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Proximal Causal Learning of Conditional Average Treatment Effects

条件平均处理效应的近端因果学习

Efficiently and flexibly estimating treatment effect heterogeneity is an important task in a wide variety of settings ranging from medicine to marketing, and there are a considerable number of promising conditional average treatment effect estimators currently available. These, however, typically rely on the assumption that the measured covariates are enough to justify conditional exchangeability. We propose the P-learner, motivated by the R- and DR-learner, a tailored…

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Signature asymptotics, empirical processes, and optimal transport

路径签名渐近理论、经验过程与最优传输

Rough path theory provides one with the notion of signature, a graded family of tensors which characterise, up to a negligible equivalence class, and ordered stream of vector-valued data. In the last few years, use of the signature has gained traction in time-series analysis, machine learning , deep learning and more recently in kernel methods. In this article, we lay down the theoretical foundations for a connection between signature asymptotics, the theory of empirical…

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Simultaneous predictive bands for functional time series using minimum entropy sets

利用最小熵集合构造函数型时间序列同时预测带

Functional Time Series are sequences of dependent random elements taking values on some functional space. Most of the research on this domain is focused on producing a predictor able to forecast the value of the next function having observed a part of the sequence. For this, the Autoregresive Hilbertian process is a suitable framework. We address here the problem of constructing simultaneous predictive confidence bands for a stationary functional time series. The method is…

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Causal Semantic Communication for Digital Twins: A Generalizable Imitation Learning Approach

数字孪生的因果语义通信:可泛化的模仿学习方法

A digital twin (DT) leverages a virtual representation of the physical world, along with communication (e.g., 6G), computing (e.g., edge computing), and artificial intelligence (AI) technologies to enable many connected intelligence services. In order to handle the large amounts of network data based on digital twins (DTs), wireless systems can exploit the paradigm of semantic communication (SC) for facilitating informed decision-making under strict communication constraints…

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Auto-Regressive Approximations to Non-stationary Time Series, with Inference and Applications

非平稳时间序列的自回归逼近:推断与应用

Understanding the time-varying structure of complex temporal systems is one of the main challenges of modern time series analysis. In this paper, we show that every uniformly-positive-definite-in-covariance and sufficiently short-range dependent non-stationary and nonlinear time series can be well approximated globally by a white-noise-driven auto-regressive (AR) process of slowly diverging order. To our best knowledge, it is the first time such a structural approximation…

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Central limit theorems for high dimensional dependent data

高维依赖数据的中心极限定理

Motivated by statistical inference problems in high-dimensional time series data analysis, we first derive non-asymptotic error bounds for Gaussian approximations of sums of high-dimensional dependent random vectors on hyper-rectangles, simple convex sets and sparsely convex sets. We investigate the quantitative effect of temporal dependence on the rates of convergence to a Gaussian random vector over three different dependency frameworks ($α$-mixing, $m$-dependent, and…

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Functional-Coefficient Quantile Regression for Panel Data with Latent Group Structure

具有潜在分组结构的面板函数系数分位数回归

This paper considers estimating functional-coefficient models in panel quantile regression with individual effects, allowing the cross-sectional and temporal dependence for large panel observations. A latent group structure is imposed on the heterogenous quantile regression models so that the number of nonparametric functional coefficients to be estimated can be reduced considerably. With the preliminary local linear quantile estimates of the subject-specific functional…

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Factor Model of Mixtures

混合分布因子模型

This paper proposes a new approach to estimating the distribution of a response variable conditioned on observing some factors. The proposed approach possesses desirable properties of flexibility, interpretability, tractability and extendability. The conditional quantile function is modeled by a mixture (weighted sum) of basis quantile functions, with the weights depending on factors. The calibration problem is formulated as a convex optimization problem. It can be viewed as…

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Estimating High Dimensional Monotone Index Models by Iterative Convex Optimization1

通过迭代凸优化估计高维单调指数模型

In this paper we propose new approaches to estimating large dimensional monotone index models. This class of models has been popular in the applied and theoretical econometrics literatures as it includes discrete choice, nonparametric transformation, and duration models. A main advantage of our approach is computational. For instance, rank estimation procedures such as those proposed in Han (1987) and Cavanagh and Sherman (1998) that optimize a nonsmooth, non convex…

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Inference on Individual Treatment Effects in Nonseparable Triangular Models

非可分三角模型中个体处理效应的统计推断

In nonseparable triangular models with a binary endogenous treatment and a binary instrumental variable, Vuong and Xu (2017) established identification results for individual treatment effects (ITEs) under the rank invariance assumption. Using their approach, Feng, Vuong, and Xu (2019) proposed a uniformly consistent kernel estimator for the density of the ITE that utilizes estimated ITEs. In this paper, we establish the asymptotic normality of the density estimator of Feng,…

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Nonparametric estimation of multivariate hidden Markov models using tensor-product B-splines

基于张量积 B 样条的多元隐马尔可夫模型非参数估计

For multivariate time series driven by underlying states, hidden Markov models (HMMs) constitute a powerful framework which can be flexibly tailored to the situation at hand. However, in practice it can be challenging to choose an adequate emission distribution for multivariate observation vectors. For example, the marginal data distribution may not immediately reveal the within-state distributional form, and also the different data streams may operate on different supports,…

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On semiparametric estimation of the intercept of the sample selection model: a kernel approach

样本选择模型截距的半参数估计:核方法

This paper presents a new perspective on the identification at infinity for the intercept of the sample selection model as identification at the boundary via a transformation of the selection index. This perspective suggests generalizations of estimation at infinity to kernel regression estimation at the boundary and further to local linear estimation at the boundary. The proposed kernel-type estimators with an estimated transformation are proven to be nonparametric-rate…

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Estimating Time-Varying Networks for High-Dimensional Time Series

高维时间序列的时变网络估计

We explore time-varying networks for high-dimensional locally stationary time series, using the large VAR model framework with both the transition and (error) precision matrices evolving smoothly over time. Two types of time-varying graphs are investigated: one containing directed edges of Granger causality linkages, and the other containing undirected edges of partial correlation linkages. Under the sparse structural assumption, we propose a penalised local linear method…

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A Bayesian Gaussian Process for Estimating a Causal Exposure Response Curve in Environmental Epidemiology

环境流行病学中因果暴露反应曲线的贝叶斯高斯过程估计

Motivated by environmental policy questions, we address the challenges of estimation, change point detection, and uncertainty quantification of a causal exposure-response function (CERF). Under a potential outcome framework, the CERF describes the relationship between a continuously varying exposure (or treatment) and its causal effect on an outcome. We propose a new Bayesian approach that relies on a Gaussian process (GP) model to estimate the CERF nonparametrically. To…

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Kernel regression analysis of tie-breaker designs

混合随机化与断点设计的核回归分析

Tie-breaker experimental designs are hybrids of Randomized Controlled Trials (RCTs) and Regression Discontinuity Designs (RDDs) in which subjects with moderate scores are placed in an RCT while subjects with extreme scores are deterministically assigned to the treatment or control group. In settings where it is unfair or uneconomical to deny the treatment to the more deserving recipients, the tie-breaker design (TBD) trades off the practical advantages of the RDD with the…

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On regression-adjusted imputation estimators of the average treatment effect

平均处理效应的回归调整插补估计量

Imputing missing potential outcomes using an estimated regression function is a natural idea for estimating causal effects. In the literature, estimators that combine imputation and regression adjustments are believed to be comparable to augmented inverse probability weighting. Accordingly, people for a long time conjectured that such estimators, while avoiding directly constructing the weights, are also doubly robust (Imbens, 2004; Stuart, 2010). Generalizing an earlier…

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Neural Spline Search for Quantile Probabilistic Modeling

用于分位数概率建模的神经样条搜索

Accurate estimation of output quantiles is crucial in many use cases, where it is desired to model the range of possibility. Modeling target distribution at arbitrary quantile levels and at arbitrary input attribute levels are important to offer a comprehensive picture of the data, and requires the quantile function to be expressive enough. The quantile function describing the target distribution using quantile levels is critical for quantile regression. Although various…

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Testing separability for continuous functional data

连续函数型数据的可分离性检验

Analyzing the covariance structure of data is a fundamental task of statistics. While this task is simple for low-dimensional observations, it becomes challenging for more intricate objects, such as multivariate functions. Here, the covariance can be so complex that just saving a non-parametric estimate is impractical and structural assumptions are necessary to tame the model. One popular assumption for space-time data is separability of the covariance into purely spatial…

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Covariate-guided Bayesian mixture model for multivariate time series

协变量引导的多元时间序列贝叶斯混合模型

With rapid development of techniques to measure brain activity and structure, statistical methods for analyzing modern brain-imaging play an important role in the advancement of science. Imaging data that measure brain function are usually multivariate time series and are heterogeneous across both imaging sources and subjects, which lead to various statistical and computational challenges. In this paper, we propose a group-based method to cluster a collection of multivariate…

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Inference on Time Series Nonparametric Conditional Moment Restrictions Using General Sieves

使用一般筛法推断时间序列非参数条件矩约束

General nonlinear sieve learnings are classes of nonlinear sieves that can approximate nonlinear functions of high dimensional variables much more flexibly than various linear sieves (or series). This paper considers general nonlinear sieve quasi-likelihood ratio (GN-QLR) based inference on expectation functionals of time series data, where the functionals of interest are based on some nonparametric function that satisfy conditional moment restrictions and are learned using…

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An Adaptive Kernel Approach to Federated Learning of Heterogeneous Causal Effects

联邦学习异质性因果效应的自适应核方法

We propose a new causal inference framework to learn causal effects from multiple, decentralized data sources in a federated setting. We introduce an adaptive transfer algorithm that learns the similarities among the data sources by utilizing Random Fourier Features to disentangle the loss function into multiple components, each of which is associated with a data source. The data sources may have different distributions; the causal effects are independently and…

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The finite sample performance of instrumental variable-based estimators of the Local Average Treatment Effect when controlling for covariates

控制协变量时工具变量局部平均处理效应估计量的有限样本表现

This paper investigates the finite sample performance of a range of parametric, semi-parametric, and non-parametric instrumental variable estimators when controlling for a fixed set of covariates to evaluate the local average treatment effect. Our simulation designs are based on empirical labor market data from the US and vary in several dimensions, including effect heterogeneity, instrument selectivity, instrument strength, outcome distribution, and sample size. Among the…

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