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fkbma: An R Package for Detecting Tailoring Variables with Free-Knot B-Splines and Bayesian Model Averaging

fkbma:以自由节点 B 样条和贝叶斯模型平均识别治疗定制变量的 R 包

Precision medicine aims to optimize treatment by identifying patient subgroups most likely to benefit from specific interventions. To support this goal, we introduce fkbma, an R package that implements a Bayesian model averaging approach with free-knot B-splines for identifying tailoring variables. The package employs a reversible jump Markov chain Monte Carlo algorithm to flexibly model treatment effect heterogeneity while accounting for uncertainty in both variable…

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Sequential Kernel Embedding for Mediated and Time-Varying Dose Response Curves

中介与时变剂量反应曲线的序贯核嵌入

We propose simple nonparametric estimators for mediated and time-varying dose response curves based on kernel ridge regression. By embedding Pearl's mediation formula and Robins' g-formula with kernels, we allow treatments, mediators, and covariates to be continuous in general spaces, and also allow for nonlinear treatment-confounder feedback. Our key innovation is a reproducing kernel Hilbert space technique called sequential kernel embedding, which we use to construct…

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lpcde: Estimation and Inference for Local Polynomial Conditional Density Estimators

lpcde:局部多项式条件密度估计与推断

This paper discusses the R package lpcde, which stands for local polynomial conditional density estimation. It implements the kernel-based local polynomial smoothing methods introduced in Cattaneo, Chandak, Jansson, Ma (2024) for statistical estimation and inference of conditional distributions, densities, and derivatives thereof. The package offers mean square error optimal bandwidth selection and associated point estimators, as well as uncertainty quantification based on…

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Targeted Sequential Indirect Experiment Design

面向目标因果问题的序贯间接实验设计

Scientific hypotheses typically concern specific aspects of complex, imperfectly understood or entirely unknown mechanisms, such as the effect of gene expression levels on phenotypes or how microbial communities influence environmental health. Such queries are inherently causal (rather than purely associational), but in many settings, experiments can not be conducted directly on the target variables of interest, but are indirect. Therefore, they perturb the target variable,…

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A projection based approach for interactive fixed effects panel data models

交互固定效应面板模型的投影估计方法

This paper introduces a straightforward sieve-based approach for estimating and conducting inference on regression parameters in panel data models with interactive fixed effects. The method's key assumption is that factor loadings can be decomposed into an unknown smooth function of individual characteristics plus an idiosyncratic error term. Our estimator offers advantages over existing approaches by taking a simple partial least squares form, eliminating the need for…

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Correcting invalid regression discontinuity designs with multiple time period data

利用多期数据修正失效的回归不连续设计

Regression Discontinuity (RD) designs rely on the continuity of potential outcome means at the cutoff, but this assumption often fails when other treatments or policies are implemented at this cutoff. We characterize the bias in sharp and fuzzy RD designs due to violations of continuity, and develop a general identification framework that leverages multiple time periods to estimate local effects on the (un)treated. We extend the framework to settings with carry-over effects…

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Efficient Estimation of Structural Models via Sieves

通过筛方法高效估计结构模型

We propose a class of sieve-based efficient estimators for structural models (SEES), which approximate the solution using a linear combination of basis functions and impose equilibrium conditions as a penalty to determine the best-fitting coefficients. Our estimators avoid the need to repeatedly solve the model, apply to a broad class of models, and are consistent, asymptotically normal, and asymptotically efficient. Moreover, they solve unconstrained optimization problems…

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A projected nonlinear state-space model for forecasting time series signals

用于时间序列信号预测的投影非线性状态空间模型

Learning and forecasting stochastic time series is essential in various scientific fields. However, despite the proposals of nonlinear filters and deep-learning methods, it remains challenging to capture nonlinear dynamics from a few noisy samples and predict future trajectories with uncertainty estimates while maintaining computational efficiency. Here, we propose a fast algorithm to learn and forecast nonlinear dynamics from noisy time series data. A key feature of the…

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Causal Inference under Interference: Regression Adjustment and Optimality

网络干扰下的因果推断:回归调整与最优性

In randomized controlled trials without interference, regression adjustment is widely used to enhance the efficiency of treatment effect estimation. This paper extends this efficiency principle to settings with network interference, where a unit's response may depend on the treatments assigned to its neighbors in a network. We make three key contributions: (1) we establish a central limit theorem for a linear regression-adjusted estimator and prove its optimality in…

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A Response to Recent Critiques of Hainmueller, Mummolo and Xu (2019) on Estimating Conditional Relationships

回应关于估计条件关系的近期批评:对 Hainmueller、Mummolo 与 Xu(2019)的澄清

Simonsohn (2024a) and Simonsohn (2024b) critique Hainmueller, Mummolo and Xu (2019, HMX), arguing that failing to model nonlinear relationships between the treatment and moderator leads to biased marginal effect estimates and uncontrolled Type-I error rates. While these critiques highlight the issue of under-modeling nonlinearity in applied research, they are fundamentally flawed in several key ways. First, the causal estimand for interaction effects and the necessary…

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Scale-Insensitive Neural Network Significance Tests

尺度不敏感的神经网络显著性检验

This paper develops a scale-insensitive framework for neural network significance testing, substantially generalizing existing approaches through three key innovations. First, we replace metric entropy calculations with Rademacher complexity bounds, enabling the analysis of neural networks without requiring bounded weights or specific architectural constraints. Second, we weaken the regularity conditions on the target function to require only Sobolev space membership $H^s([-1,1]^d)$…

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A Bivariate Transformation Model for Time-to-Event Data Affected by Unobserved Confounding: Revisiting the Illinois Reemployment Bonus Experiment

未观测混杂下事件时间数据的二元变换模型:重访伊利诺伊再就业奖励实验

Motivated by empirical studies investigating treatment effects in survival analysis, we propose a bivariate transformation model to quantify the impact of a binary treatment on a time-to-event outcome. The model equations are connected through a bivariate Gaussian distribution, with the dependence parameter capturing unobserved confounding, and are specified as functions of additive predictors to flexibly account for the impacts of observed confounders. Moreover, the…

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Semiparametric Localized Principal Stratification Analysis with Continuous Strata

连续主分层的半参数局部化分析

Principal stratification is essential for revealing causal mechanisms involving post-treatment intermediate variables, in real-world applications like surrogate marker evaluation. Principal stratification analysis with continuous intermediate variables is increasingly common but challenging due to the infinite principal strata and the nonidentifiability and nonregularity of principal causal effects. Inspired by recent research, we resolve these challenges by first using a…

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A Note on Doubly Robust Estimator in Regression Discontinuity Designs

关于回归不连续设计中双重稳健估计量的说明

This note introduces a doubly robust (DR) estimator for regression discontinuity (RD) designs. RD designs provide a quasi-experimental framework for estimating treatment effects, where treatment assignment depends on whether a running variable surpasses a predefined cutoff. A common approach in RD estimation is the use of nonparametric regression methods, such as local linear regression. However, the validity of these methods still relies on the consistency of the…

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Optimizing Financial Data Analysis: A Comparative Study of Preprocessing Techniques for Regression Modeling of Apple Inc.'s Net Income and Stock Prices

苹果公司净利润与股价回归中的金融数据预处理比较

This article presents a comprehensive methodology for processing financial datasets of Apple Inc., encompassing quarterly income and daily stock prices, spanning from March 31, 2009, to December 31, 2023. Leveraging 60 observations for quarterly income and 3774 observations for daily stock prices, sourced from Macrotrends and Yahoo Finance respectively, the study outlines five distinct datasets crafted through varied preprocessing techniques. Through detailed explanations of…

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Kernel methods for long term dose response curves

长期剂量反应曲线的核方法

A core challenge in causal inference is how to extrapolate long term effects, of possibly continuous actions, from short term experimental data. It arises in artificial intelligence: the long term consequences of continuous actions may be of interest, yet only short term rewards may be collected in exploration. For this estimand, called the long term dose response curve, we propose a simple nonparametric estimator based on kernel ridge regression. By embedding the…

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From sparse to dense functional time series: phase transitions of detecting structural breaks and beyond

从稀疏到稠密的函数型时间序列:结构突变检测的相变及拓展

We develop a novel methodology for detecting abrupt break points in mean functions of functional time series, adaptable to arbitrary sampling schemes. By employing B-spline smoothing, we introduce $\mathcal L_{\infty}$ and $\mathcal L_2$ test statistics statistics based on a smoothed cumulative summation (CUMSUM) process, and derive the corresponding asymptotic distributions under the null and local alternative hypothesis, as well as the phase transition boundary from sparse…

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Nonparametric Regression under Cluster Sampling

聚类抽样下的非参数回归

This paper develops a general asymptotic theory for nonparametric kernel regression in the presence of cluster dependence. We examine nonparametric density estimation, Nadaraya-Watson kernel regression, and local linear estimation. Our theory accommodates growing and heterogeneous cluster sizes. We derive asymptotic conditional bias and variance, establish uniform consistency, and prove asymptotic normality. Our findings reveal that under heterogeneous cluster sizes, the…

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Semiparametric Inference for Regression-Discontinuity Designs

回归不连续设计的半参数推断

Treatment effects in regression discontinuity designs (RDDs) are often estimated using local regression methods. \cite{Hahn:01} demonstrated that the identification of the average treatment effect at the cutoff in RDDs relies on the unconfoundedness assumption and that, without this assumption, only the local average treatment effect at the cutoff can be identified. In this paper, we propose a semiparametric framework tailored for identifying the average treatment effect in…

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Dual Interpretation of Machine Learning Forecasts

机器学习预测的对偶解释

Machine learning predictions are typically interpreted as the sum of contributions of predictors. Yet, each out-of-sample prediction can also be expressed as a linear combination of in-sample values of the predicted variable, with weights corresponding to pairwise proximity scores between current and past economic events. While this dual route leads nowhere in some contexts (e.g., large cross-sectional datasets), it provides sparser interpretations in settings with many…

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Semiparametric Discrete Choice Models for Bundles

组合商品选择的半参数离散选择模型

We propose two approaches to estimate semiparametric discrete choice models for bundles. Our first approach is a kernel-weighted rank estimator based on a matching-based identification strategy. We establish its complete asymptotic properties and prove the validity of the nonparametric bootstrap for inference. We then introduce a new multi-index least absolute deviations (LAD) estimator as an alternative, of which the main advantage is its capacity to estimate preference…

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One-step smoothing splines instrumental regression

一步平滑样条工具变量回归

We extend nonparametric regression smoothing splines to a context where there is endogeneity and instrumental variables are available. Unlike popular existing estimators, the resulting estimator is one-step and relies on a unique regularization parameter. We derive rates of the convergence for the estimator and its first derivative, which are uniform in the support of the endogenous variable. We also address the issue of imposing monotonicity in estimation and extend the…

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Convolution Mode Regression

卷积众数回归

For highly skewed or fat-tailed distributions, mean or median-based methods often fail to capture the central tendencies in the data. Despite being a viable alternative, estimating the conditional mode given certain covariates (or mode regression) presents significant challenges. Nonparametric approaches suffer from the "curse of dimensionality", while semiparametric strategies often lead to non-convex optimization problems. In order to avoid these issues, we propose a novel…

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Debiased Regression for Root-N-Consistent Conditional Mean Estimation

用于条件均值根号样本量一致估计的去偏回归

This study introduces a debiasing method for regression estimators, including high-dimensional and nonparametric regression estimators. For example, nonparametric regression methods allow for the estimation of regression functions in a data-driven manner with minimal assumptions; however, these methods typically fail to achieve $\sqrt{n}$-consistency in their convergence rates, and many, including those in machine learning, lack guarantees that their estimators…

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