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A joint QoL-Survival framework with debiased estimation under truncation by death

死亡截断下生活质量与生存的联合框架及去偏估计

Evaluating quality-of-life (QoL) outcomes in populations with high mortality risk is complicated by truncation by death, since QoL is undefined for individuals who do not survive to the planned measurement time. We propose a framework that jointly models the distribution of QoL and survival without extrapolating QoL beyond death. Inspired by multistate formulations, we extend the joint characterization of binary health states and mortality to continuous QoL outcomes. Because…

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Identification and Estimation of Seller Risk Aversion in Ascending Auctions

升价拍卖中卖方风险厌恶的识别与估计

This paper shows how to identify and estimate the seller's risk parameter in an ascending auction. We consider a semiparametric model where the seller has a parametric utility function (such as CARA or CRRA) and the distribution of bidder valuations is modeled flexibly. We provide primitive conditions under which the risk parameter is identified and show that it can be consistently estimated with an asymptotically normal limiting distribution under standard regularity…

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Identification and Debiased Learning of Causal Effects with General Instrumental Variables

一般工具变量下因果效应的识别与去偏学习

Instrumental variable methods are fundamental to causal inference when treatment assignment is confounded by unobserved variables. In this article, we develop a general nonparametric causal framework for identification and learning with multi-categorical or continuous instrumental variables. Specifically, the mean potential outcomes and the average treatment effect can be identified via a regular weighting function derived from the proposed framework. Leveraging…

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Nonparametric Inference with an Instrumental Variable under a Separable Binary Treatment Choice Model

可分二元治疗选择模型下的工具变量非参数推断

Instrumental variable (IV) methods are widely used to infer treatment effects in the presence of unmeasured confounding. In this paper, we study nonparametric inference with an IV under a separable binary treatment choice model, which posits that the odds of the probability of taking the treatment, conditional on the instrument and the treatment-free potential outcome, factor into separable components for each variable. While nonparametric identification of smooth…

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Causal Inference for Preprocessed Outcomes with an Application to Functional Connectivity

预处理结局的因果推断及其在功能连接中的应用

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific outcomes that are not directly observable. Although intra-subject processing is widely used, its impact on inter-subject statistical inference has not been systematically studied, and a principled framework for causal analysis in this setting is…

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Powering RCTs for marginal effects with GLMs using prognostic score adjustment

用预后评分调整提升广义线性模型随机试验边际效应分析的功效

In randomized clinical trials (RCTs), the accurate estimation of marginal treatment effects is crucial for determining the efficacy of interventions. Enhancing the statistical power of these analyses is a key objective for statisticians. The increasing availability of historical data from registries, prior trials, and health records presents an opportunity to improve trial efficiency. However, many methods for historical borrowing compromise strict type-I error rate control.…

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Incremental effects for continuous exposures

连续暴露的增量效应

Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the exposure (i.e., positivity). To avoid this assumption, we consider stochastic interventions based on exponentially tilting the treatment distribution by some parameter $δ$ (an incremental effect); this increases or decreases the likelihood…

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Semiparametric Efficient Empirical Higher Order Influence Function Estimators

半参数有效的经验高阶影响函数估计量

Robins et al. (2008, 2017) applied the theory of higher order influence functions (HOIFs) to derive an estimator of the mean $ψ$ of an outcome Y in a missing data model with Y missing at random conditional on a vector X of continuous covariates; their estimator, in contrast to previous estimators, is semiparametric efficient under the minimal conditions of Robins et al. (2009b), together with an additional (non-minimal) smoothness condition on the density g of X, because the…

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Efficient Difference-in-Differences Estimation when Outcomes are Missing at Random

结果随机缺失时的有效双重差分估计

The Difference-in-Differences (DiD) method is a fundamental tool for causal inference, yet its application is often complicated by missing data. Although recent work has developed robust DiD estimators for complex settings like staggered treatment adoption, these methods typically assume complete data and fail to address the critical challenge of outcomes that are missing at random (MAR) -- a common problem that invalidates standard estimators. We develop a rigorous…

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Parameterising the effect of a continuous treatment using average derivative effects

用平均导数效应参数化连续处理的影响

The average treatment effect (ATE) is commonly used to quantify the main effect of a binary treatment on an outcome. Extensions to continuous treatments are usually based on the dose-response curve or shift interventions, but both require strong overlap conditions and the resulting curves may be difficult to summarise. We focus instead on average derivative effects (ADEs) that are scalar estimands related to infinitesimal shift interventions requiring only local overlap…

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Optimal estimation of generalized causal effects in cluster-randomized trials with multiple outcomes

多结局整群随机试验中广义因果效应的最优估计

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of treatment effect, yet existing methods largely focus on single-outcome estimands or rely on model-based procedures with unclear causal interpretation or limited robustness. We develop a unified potential outcomes framework for generalized…

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Interpolated stochastic interventions based on propensity scores, target policies and treatment-specific costs

基于倾向得分、目标政策与处理成本的插值随机干预

We introduce two families of stochastic interventions with discrete treatments that connect causal modeling to cost-sensitive decision making. The interventions arise from a cost-penalized information projection of the independent product of the organic propensity scores and a reference policy, yielding closed-form Boltzmann-Gibbs couplings. The induced marginals define modified stochastic policies that interpolate smoothly, via a tilt parameter, from the organic law or from…

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Semiparametric inference for inequality measures under nonignorable nonresponse using callback data

利用回访数据处理非可忽略无应答下不平等指标的半参数推断

This paper develops semiparametric methods for estimation and inference of widely used inequality measures when survey data are subject to nonignorable nonresponse, a challenging setting in which response probabilities depend on the unobserved outcomes. Such nonresponse mechanisms are common in household surveys and invalidate standard inference procedures due to selection bias and lack of population representativeness. We address this problem by exploiting callback data…

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Quantile Selection in the Gender Pay Gap

性别工资差距中的分位数选择校正

We propose a new approach to estimate selection-corrected quantiles of the gender wage gap. Our method employs instrumental variables that explain variation in the latent variable but, conditional on the latent process, do not directly affect selection. We provide semiparametric identification of the quantile parameters without imposing parametric restrictions on the selection probability, derive the asymptotic distribution of the proposed estimator based on constrained…

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Minimum Wasserstein distance estimator under covariate shift: closed-form, super-efficiency and irregularity

协变量漂移下的最小 Wasserstein 距离估计:闭式解、超效率与非正则性

Covariate shift arises when covariate distributions differ between source and target populations while the conditional distribution of the response remains invariant, and it underlies problems in missing data and causal inference. We propose a minimum Wasserstein distance estimation framework for inference under covariate shift that avoids explicit modeling of outcome regressions or importance weights. The resulting W-estimator admits a closed-form expression and is…

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Semiparametric Analysis of Interval-Censored Data Subject to Inaccurate Diagnoses with A Terminal Event

带终末事件与不准确诊断的区间删失数据半参数分析

Interval-censoring frequently occurs in studies of chronic diseases where disease status is inferred from intermittently collected biomarkers. Although many methods have been developed to analyze such data, they typically assume perfect disease diagnosis, which often does not hold in practice due to the inherent imperfect clinical diagnosis of cognitive functions or measurement errors of biomarkers such as cerebrospinal fluid. In this work, we introduce a semiparametric…

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Semiparametric causal mediation analysis of cluster-randomized trials for indirect and spillover effects

集群随机试验中间接效应与溢出效应的半参数因果中介分析

In cluster-randomized trials (CRTs), there is emerging interest in exploring the causal mechanism in which a cluster-level treatment affects the outcome through an intermediate outcome. The majority of existing causal mediation methods are applicable to independent data and only a few exceptions have considered assessing causal mediation in CRTs, all of which heavily depend on parametric assumptions. In this article, we develop a formal semiparametric efficiency theory to…

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Efficient Inference for Noisy LLM-as-a-Judge Evaluation

Large language models (LLMs) are increasingly used as automatic evaluators of generative AI outputs, a paradigm often referred to as "LLM-as-a-judge." In practice, LLM judges are imperfect predictions for the underlying truth and can exhibit systematic, non-random errors. Two main approaches have recently been proposed to address this issue: (i) direct measurementerror correction based on misclassification models such as Rogan-Gladen-style estimators, and (ii)…

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Ill-Conditioned Orthogonal Scores in Double Machine Learning

双重机器学习中病态正交得分的误差放大

Double Machine Learning is often justified by nuisance-rate conditions, yet finite-sample reliability also depends on the conditioning of the orthogonal-score Jacobian. This conditioning is typically assumed rather than tracked. When residualized treatment variance is small, the Jacobian is ill-conditioned and small systematic nuisance errors can be amplified, so nominal confidence intervals may look precise yet systematically under-cover. Our main result is an exact…

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Semismooth Newton Augmented Lagrangian Algorithm for Adaptive Lasso Penalized Least Squares in Semiparametric Regression

This paper is concerned with a partially linear semiparametric regression model containing an unknown regression coefficient, an unknown nonparametric function, and an unobservable Gaussian distributed random error. We focus on the case of simultaneous variable selection and estimation with a divergent number of covariates under the assumption that the regression coefficient is sparse. We consider the applications of the least squares to semiparametric regression and…

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Difference-in-Differences using Double Negative Controls and Graph Neural Networks for Unmeasured Network Confounding

结合双重负向控制与图神经网络的双重差分:处理未观测网络混杂

Estimating causal effects from observational network data faces dual challenges of network interference and unmeasured confounding. To address this, we propose a general Difference-in-Differences framework that integrates double negative controls (DNC) and graph neural networks (GNNs). Based on the modified parallel trends assumption and DNC, semiparametric identification of direct and indirect causal effects is established. We then propose doubly robust estimators.…

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Nonparametric Instrumental Variable Inference with Many Weak Instruments

多弱工具变量下的非参数工具变量推断

We study inference on linear functionals in the nonparametric instrumental variable (NPIV) problem with a discretely-valued instrument under a many-weak-instruments asymptotic regime, where the number of instrument values grows with the sample size. A key motivating example is estimating long-term causal effects in a new experiment with only short-term outcomes, using past experiments to instrument for the effect of short- on long-term outcomes. Here, the assignment to a…

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Inference on High Dimensional Selective Labeling Models

高维选择性标签模型的统计推断

A class of simultaneous equation models arise in the many domains where observed binary outcomes are themselves a consequence of the existing choices of of one of the agents in the model. These models are gaining increasing interest in the computer science and machine learning literatures where they refer the potentially endogenous sample selection as the {\em selective labels} problem. Empirical settings for such models arise in fields as diverse as criminal justice, health…

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Principal stratification with U-statistics under principal ignorability

主分层可忽略性下基于 U 统计量的主分层推断

Principal stratification is a popular framework for causal inference in the presence of an intermediate outcome. While the principal average treatment effects are the standard target of inference, they may be insufficient when interest lies in the relative ordering of potential outcomes within a principal stratum. We introduce the principal generalized causal effect estimands to accommodate nonlinear contrast functions, providing robust, probability-scale summaries suitable…

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