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Hybrid Meta-learners for Estimating Heterogeneous Treatment Effects

估计异质性处理效应的混合元学习器

Estimating conditional average treatment effects (CATE) from observational data involves modeling decisions that differ from supervised learning, particularly concerning how to regularize model complexity. Previous approaches can be grouped into two primary "meta-learner" paradigms that impose distinct inductive biases. Indirect meta-learners first fit and regularize separate potential outcome (PO) models and then estimate CATE by taking their difference, whereas direct…

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Bootstrapping Lasso in Generalized Linear Models

广义线性模型中的 Lasso 自助法

Generalized linear model or GLM constitutes a large class of models and essentially extends the ordinary linear regression by connecting the mean of the response variable with the covariate through appropriate link functions. On the other hand, Lasso is a popular and easy-to-implement penalization method in regression when not all covariates are relevant. However, the asymptotic distributional properties the Lasso estimator in GLM is still unknown. In this paper, we show…

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Extending Mean-Field Variational Inference via Entropic Regularization: Theory and Computation

基于熵正则化的扩展平均场变分推断:理论与计算

Variational inference (VI) has emerged as a popular method for approximate inference for high-dimensional Bayesian models. In this paper, we propose a novel VI method that extends the naive mean field via entropic regularization, referred to as $Ξ$-variational inference ($Ξ$-VI). $Ξ$-VI has a close connection to the entropic optimal transport problem and benefits from the computationally efficient Sinkhorn algorithm. We show that $Ξ$-variational posteriors effectively…

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Information-geometry-driven graph sequential growth

信息几何驱动的高斯图模型序贯增长

We investigate the properties of a class of regularisation-free approaches for Gaussian graphical inference based on the information-geometry-driven sequential growth of initially edgeless graphs. Relating the growth of a graph to a coordinate descent process, we characterise the fully-corrective descents corresponding to information-optimal growths, and propose numerically efficient strategies for their approximation. We demonstrate the ability of the proposed procedures to…

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Comparing regularisation paths of (conjugate) gradient estimators in ridge regression

岭回归中(共轭)梯度估计量的正则化路径比较

We consider standard gradient descent, gradient flow and conjugate gradients as iterative algorithms for minimising a penalised ridge criterion in linear regression. While it is well known that conjugate gradients exhibit fast numerical convergence, the statistical properties of their iterates are more difficult to assess due to inherent non-linearities and dependencies. On the other hand, standard gradient flow is a linear method with well-known regularising properties when…

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Towards regularized learning from functional data with covariate shift

面向协变量偏移下函数型数据的正则化学习

This paper investigates a general regularization framework for unsupervised domain adaptation in vector-valued regression under the covariate shift assumption, utilizing vector-valued reproducing kernel Hilbert spaces (vRKHS). Covariate shift occurs when the input distributions of the training and test data differ, introducing significant challenges for reliable learning. By restricting the hypothesis space, we develop a practical operator learning algorithm capable of…

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Causal Inference in Biomedical Imaging via Functional Linear Structural Equation Models

通过函数型线性结构方程模型推断生物医学影像的因果效应

Understanding the causal effects of organ-specific features from medical imaging on clinical outcomes is essential for biomedical research and patient care. We propose a novel Functional Linear Structural Equation Model (FLSEM) to capture the relationships among clinical outcomes, functional imaging exposures, and scalar covariates like genetics, sex, and age. Traditional methods struggle with the infinite-dimensional nature of exposures and complex covariates. Our FLSEM…

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Robust functional PCA for relative data

面向相对数据的稳健函数型主成分分析

This paper introduces a robust approach to functional principal component analysis (FPCA) for relative data, particularly density functions. While recent papers have studied density data within the Bayes space framework, there has been limited focus on developing robust methods to effectively handle anomalous observations and large noise. To address this, we extend the Mahalanobis distance concept to Bayes spaces, proposing its regularized version that accounts for the…

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Normalized Fractional Order Entropy-Based Decision-Making Models under Risk

风险下的归一化分数阶熵决策模型

Constructing efficient portfolios requires balancing expected returns with risk through optimal stock selection, while accounting for investor preferences. In a recent work by Paul and Kundu (2026), the fractional-order entropy due to Ubriaco was introduced as an uncertainty measure to capture varying investor attitudes toward risk. Building on this foundation, we introduce a novel normalized fractional order entropy aligned with investors' risk preferences that combines…

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Multi-omics network reconstruction with collaborative graphical lasso

协作图套索的多组学网络重建

Motivation: In recent years, the availability of multi-omics data has increased substantially. Multi-omics data integration methods mainly aim to leverage different molecular layers to gain a complete molecular description of biological processes. An attractive integration approach is the reconstruction of multi-omics networks. However, the development of effective multi-omics network reconstruction strategies lags behind. Results: In this study, we introduce collaborative…

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High-dimensional estimation of quadratic variation based on penalized realized variance

基于惩罚已实现方差的高维二次变差估计

In this paper, we develop a penalized realized variance (PRV) estimator of the quadratic variation (QV) of a high-dimensional continuous Itô semimartingale. We adapt the principle idea of regularization from linear regression to covariance estimation in a continuous-time high-frequency setting. We show that under a nuclear norm penalization, the PRV is computed by soft-thresholding the eigenvalues of realized variance (RV). It therefore encourages sparsity of singular values…

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A Generalized Adaptive Joint Learning Framework for High-Dimensional Time-Varying Models

高维时变模型的广义自适应联合学习框架

In modern biomedical and econometric studies, longitudinal processes are often characterized by complex time-varying associations and abrupt regime shifts that are shared across correlated outcomes. Standard functional data analysis (FDA) methods, which prioritize smoothness, often fail to capture these dynamic structural features, particularly in high-dimensional settings. This article introduces Adaptive Joint Learning (AJL), a hierarchical regularization framework…

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Maximum softly penalised likelihood in factor analysis

因子分析中的最大软惩罚似然估计

Estimation in exploratory factor analysis often yields estimates on the boundary of the parameter space. Such occurrences, known as Heywood cases, are characterised by non-positive variance estimates and can cause issues in numerical optimisation procedures or convergence failures, which, in turn, can lead to misleading inferences, particularly regarding factor scores and model selection. We derive sufficient conditions on the model and a penalty to the log-likelihood…

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BASTION: A Bayesian Framework for Trend and Seasonality Decomposition

BASTION:趋势与季节性分解的贝叶斯框架

We introduce BASTION (Bayesian Adaptive Seasonality and Trend DecompositION), a flexible Bayesian framework for decomposing time series into trend and multiple seasonality components. We cast the decomposition as a penalized nonparametric regression and establish formal conditions under which the trend and seasonal components are uniquely identifiable, an issue only treated informally in the existing literature. BASTION offers three key advantages over existing decomposition…

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ARMAr-LASSO: Mitigating the Impact of Predictor Serial Correlation on the LASSO

ARMAr-LASSO:缓解预测变量序列相关对 LASSO 的影响

We explore estimation and forecast accuracy for sparse linear models, focusing on scenarios where both predictors and errors carry serial correlations. We establish a clear link between predictor serial correlation and the performance of the LASSO, showing that even orthogonal or weakly correlated stationary AR processes can lead to significant spurious correlations due to their serial correlations. To address this challenge, we propose a novel approach named ARMAr-LASSO…

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Kernel-Based Nonparametric Tests For Shape Constraints

基于核方法的非参数形状约束检验

We propose a kernel-based nonparametric framework for mean-variance optimization that enables inference on economically motivated shape constraints in finance, including positivity, monotonicity, and convexity. Many central hypotheses in financial econometrics are naturally expressed as shape relations on latent functions (e.g., term premia, CAPM relations, and the pricing kernel), yet enforcing such constraints during estimation can mask economically meaningful violations;…

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Finite-Sample Inference for Sparsely Permuted Linear Regression

稀疏置换线性回归的有限样本推断

We study a linear observation model with an unknown permutation called \textit{permuted/shuffled linear regression}, where responses and covariates are mismatched and the permutation forms a discrete, factorial-size parameter. The permutation is a key component of the data-generating process, yet its statistical investigation remains challenging due to its discrete nature. We develop a general statistical inference framework on the permutation and regression coefficients.…

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Univariate-Guided Sparse Regression for Biobank-Scale High-Dimensional Omics Data

面向生物样本库规模高维组学数据的单变量引导稀疏回归

We present a scalable framework for computing polygenic risk scores (PRS) in high-dimensional genomic settings using the recently introduced Univariate-Guided Sparse Regression (uniLasso). UniLasso is a two-stage penalized regression procedure that leverages univariate coefficients and magnitudes to stabilize feature selection and enhance interpretability. Building on its theoretical and empirical advantages, we adapt uniLasso for application to the UK Biobank, a…

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Estimating Gaussian graphical models of multi-study data with Multi-Study Factor Analysis

多研究数据的因子分析高斯图模型估计

Network models are powerful tools for gaining new insights from complex biological data. Most lines of investigation in biology involve comparing datasets in the setting where the same predictors are measured across multiple studies or conditions (multi-study data). Consequently, the development of statistical tools for network modeling of multi-study data is a highly active area of research. Multi-study factor analysis (MSFA) is a method for estimation of latent variables…

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Uniform Consistency of Generalized Cross-Validation for Ridge Regression in High-Dimensional Misspecified Linear Models

高维误设线性模型中岭回归广义交叉验证的一致相合性

This study examines generalized cross-validation for the tuning parameter selection for ridge regression in high-dimensional misspecified linear models. The set of candidates for the tuning parameter includes not only positive values but also zero and negative values. We demonstrate that if the second moment of the specification error converges to zero, generalized cross-validation is still a uniformly consistent estimator of the out-of-sample prediction risk. This implies…

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Interpolated stochastic interventions based on propensity scores, target policies and treatment-specific costs

基于倾向得分、目标政策与处理成本的插值随机干预

We introduce two families of stochastic interventions with discrete treatments that connect causal modeling to cost-sensitive decision making. The interventions arise from a cost-penalized information projection of the independent product of the organic propensity scores and a reference policy, yielding closed-form Boltzmann-Gibbs couplings. The induced marginals define modified stochastic policies that interpolate smoothly, via a tilt parameter, from the organic law or from…

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Distribution-Free Confidence Ellipsoids for Ridge Regression with PAC Bounds

岭回归的无分布置信椭球与PAC界

Linearly parametrized models are widely used in control and signal processing, with the least-squares (LS) estimate being the archetypical solution. When the input is insufficiently exciting, the LS problem may be unsolvable or numerically unstable. This issue can be resolved through regularization, typically with ridge regression. Although regularized estimators reduce the variance error, it remains important to quantify their estimation uncertainty. A possible approach for…

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Spectral Dynamics and Regularization for High-Dimensional Copulas

高维 Copula 的谱动态与正则化

We introduce a novel model for time-varying, asymmetric, tail-dependent copulas in high dimensions that incorporates both spectral dynamics and regularization. The dynamics of the dependence matrix' eigenvalues are modeled in a score-driven way, while biases in the unconditional eigenvalue spectrum are resolved by non-linear shrinkage. The dynamic parameterization of the copula dependence matrix ensures that it satisfies the appropriate restrictions at all times and for any…

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The distribution of Ridgeless least squares interpolators

无岭最小二乘插值估计量的分布

The Ridgeless minimum $\ell_2$-norm interpolator in overparametrized linear regression has attracted considerable attention in recent years in both machine learning and statistics communities. While it seems to defy conventional wisdom that overfitting leads to poor prediction, recent theoretical research on its $\ell_2$-type risks reveals that its norm minimizing property induces an `implicit regularization' that helps prediction in spite of interpolation. This paper takes…

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