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Piecewise Constant Hazard Estimation with the Fused Lasso

融合套索下的分段常数风险率估计

In applied time-to-event analysis, a flexible and useful approach is to model the hazard rate as a piecewise constant function of time. However, the change points and values of the piecewise constant hazard are usually unknown and need to be estimated. In this paper, we develop a fully data-driven procedure for piecewise constant hazard estimation. We work in a general counting process framework which nests a wide range of popular models in time-to-event analysis including…

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Which Regularized Propensity-Score and Doubly Robust Methods Are Best Calibrated When Exposures or Outcomes Are Rare? A Plasmode Study of Proxy-Based Confounding Adjustment

暴露或结局罕见时哪种正则化倾向得分与双稳健方法校准最佳?基于代理混杂调整的plasmode研究

Purpose. Confounding adjustment in health-care database studies screens large proxy libraries where events per variable are low, straining standard propensity score (PS) methods, and many regularized variable-selection strategies exist (outcome-adaptive LASSO [OAL], group LASSO/GLiDeR, highly adaptive LASSO [HAL]). Yet few comparisons have varied exposure prevalence within such a selection menu, and none pairs it with doubly robust estimation, compute accounting, and a…

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Multivariate Bayesian P-spline estimation of spectral density matrices, with application to LISA TDI noise

谱密度矩阵的多元贝叶斯 P 样条估计及 LISA TDI 噪声应用

We present a Bayesian P-spline method for estimating the frequency-dependent cross-spectral density matrix of stationary multivariate time series. The inverse spectral matrix is parametrised through its frequency-varying Cholesky decomposition, which guarantees Hermitian positive definiteness at every frequency. Each real log-diagonal entry and each real and imaginary off-diagonal entry is given an independent penalised B-spline prior that controls smoothness. Inference uses…

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Doubly cross-fit debiased machine learning of heterogeneous treatment effects under principal stratification

主分层下异质性处理效应的双重交叉拟合去偏机器学习

Principal stratification provides a foundational framework for causal inference with intermediate outcomes by defining causal effects within subpopulations, yet existing work has largely focused on average effects across strata rather than treatment effect heterogeneity within strata. Such within-stratum heterogeneity informs individualized treatment decisions but the associated methods are sparse. We address this gap by studying the identification and estimation of the…

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Factor-Augmented Machine Learning Panel Regressions

因子增强的机器学习面板回归

This paper develops the asymptotic theory for high-dimensional panel data regressions in settings with cross-sectionally dependent errors driven by common shocks. We consider a factor-augmented sparse-group LASSO estimator that combines MIDAS aggregation with latent factors. The estimator can take advantage of the mixed-frequency group structure in the time-series dimension. Theory shows that it can outperform the standard LASSO estimator both for prediction and estimation…

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Approximate Risk Minimization Over Shrinking-Thresholding Rules in Normal Mean Estimation

正态均值估计中收缩阈值规则的近似风险最小化

We develop an approximate risk minimization framework for shrinkage-thresholding estimation in normal mean problems. In the canonical multivariate normal mean model, we introduce a general functional class of estimators that contains classical shrinkage and thresholding behavior, including James-Stein-type and lasso-type rules. We express quadratic risk as a functional over this class, derive optimality conditions for both oracle risk and data-driven approximate risk…

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Smooth Reduced Rank Regression with P-splines

基于P样条的平滑降秩回归

Linear regression is one of the core statistical tools used for analysis of data. In the era of statistical learning, linear regression has been expanded into two directions. The first is regularisation, where penalties are added to the loss function to obtain more stable or sparse solutions. The second direction is basis expansion, such as with spline or kernel functions, where the linearity assumption is dropped. In practice, empirical researchers often collect multiple…

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Post-Learning Inference for Combinatorial Optimizers with High-Dimensional Sparse Contextual Information via Minimal Directional Perturbation

高维稀疏情境信息下组合优化器的学习后推断:最小方向扰动方法

We study post-learning inference for structural properties of data-dependent combinatorial optimizers. The target is whether an oracle optimizer, rather than a latent parameter or smooth functional, belongs to a prescribed class, such as a category-mix, inventory, or resource-feasibility class. We focus on a high-dimensional contextual multinomial logit model with sequentially adaptive data collection, where the parameter-to-optimizer map is discontinuous and the policy…

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Minimax prediction in the Functional Autoregressive Model

函数自回归模型中的极小极大预测

The Functional Autoregressive Model (FAR) generalizes the multivariate AR(1) model in Time Series Analysis to functional data. It serves as a historical foundational point in the study of functional time series and remains a fundamental and widely used model for dependent functional data. The process-the observed data-generated by the FAR model forms a Hilbert-valued Markov chain. This paper investigates the non-asymptotic prediction mean square error and derives a lower…

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Targeted Data Fusion for Region-Specific Survival Effects in the AMP HIV Prevention Trials

AMP 艾滋病预防试验中地区特异性生存效应的定向数据融合

The Antibody Mediated Prevention (AMP) trials opened a new scientific frontier by showing that passively administered monoclonal broadly neutralizing antibodies (bnAbs) could prevent HIV-1 acquisition. Conducted across multiple geographic regions, including the United States, Brazil, Peru, Switzerland, and sub-Saharan Africa, the AMP trials revealed substantial regional heterogeneity in treatment efficacy. These differences, together with privacy and regulatory limits on…

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Efficient Cross-Validation for Sparse Linear Regression

稀疏线性回归的高效交叉验证

Given a high-dimensional covariate matrix and a response vector, ridge-regularized sparse linear regression selects a subset of features that explains the relationship between covariates and the response in an interpretable manner. To choose hyperparameters that control the sparsity level and amount of regularization, practitioners commonly use k-fold cross-validation. However, cross-validation substantially increases the computational cost of sparse regression as it…

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Targeted Highly Adaptive Lasso Minimum Loss Estimation of Target Functions

目标函数的目标化高度自适应Lasso最小损失估计

We propose a Targeted Highly Adaptive Lasso for estimation of non-pathwise differentiable functional parameters such as the dose-response curve (DRC) for continuous exposure. We assume the target function lies in the $k$-th order smoothness class used to define the $k$-th order Highly Adaptive Lasso (HAL), which can be well approximated by linear spans of $k$-th order spline basis functions. We construct a projection of the true target function onto a large finite…

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Transfer Learning in High-dimensional Ising Models

高维伊辛模型中的迁移学习

In high-dimensional Ising model estimation, target sample sizes are often limited, and effectively using auxiliary binary datasets of unknown relevance remains challenging. To address this, we propose Trans-Ising, a transfer learning method that combines a loss-based source screening rule with a two-stage estimation procedure. The method first identifies informative auxiliary sources using held-out target pseudolikelihood to prevent negative transfer. It then computes an…

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Data-Driven Logistic Regression Ensembles With Applications in Genomics

数据驱动的逻辑回归集成方法及其在基因组学中的应用

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker identification. We introduce a novel approach to high-dimensional binary classification that integrates regularization with ensembling techniques. The method constructs compact ensembles of interpretable models derived by optimizing a…

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Asymptotic theory and first-order bias of the Wallace--Freeman estimator

Wallace--Freeman 估计量的渐近理论与一阶偏差

The Wallace--Freeman estimator is a classical minimum message length estimator whose relationship with likelihood-based asymptotic theory has not been fully developed. We show that, in regular parametric models, the Wallace--Freeman criterion is equivalent, up to constants, to a penalised likelihood criterion with penalty weight \(n^{-1}\). This representation places the estimator within the standard theory of penalised M-estimation and yields existence, consistency, an…

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On Regularization via Early Stopping for Least Squares Regression

最小二乘回归中早停正则化的研究

A fundamental problem in machine learning is understanding the effect of early stopping on the parameters obtained and the generalization capabilities of the model. Even for linear models, the effect is not fully understood for arbitrary learning rates and data. In this paper, we analyze the dynamics of discrete full batch gradient descent for linear regression. With minimal distributional assumptions, we characterize the trajectory of the parameters and the expected excess…

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Contaminated Multi-task Learning with Heterogeneity: Fundamental Limits and Optimal Algorithms

异质性下的受污染多任务学习:基本极限与最优算法

Integrating information across related tasks can improve estimation and prediction in transfer, multi-task, and federated learning, but contamination and heterogeneity make robust borrowing challenging. We study a contaminated multi-task empirical risk minimization (ERM) framework in which an $ε$ fraction of $K$ tasks, each with sample size $n$, may be arbitrarily contaminated while the remaining tasks are heterogeneous. Our goal is to estimate both the global minimizer of…

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Pointwise Complexity for Gaussian Fields: Upper Envelopes, Algorithmic Lower Bounds, and Separation

高斯场的逐点复杂度:上包络、算法下界与分离

We prove a variance-aware pointwise majorizing-measure theorem for centered Gaussian processes. Classical generic chaining characterizes the scalar quantity $\mathbb E\sup_{x\in T}X_x$; the theorem here gives a simultaneous high-probability envelope for the entire field. For an ambient prior $μ$, the envelope at $x$ is governed by a pointwise Fernique-Talagrand functional \[Φ_μ(x):=\int_0^{4σ(x)}\sqrt{\log\frac{1}{μ(B_d(x,\varepsilon))}}\,d\varepsilon,\] together with the…

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Regularized Variational and Spectral Log-Density-Ratio Estimation in the Gaussian Location Model

高斯位置模型中正则化变分与谱对数密度比估计

We study ridge-regularized log-density-ratio estimation in the Gaussian location model with a common covariance matrix. By affine invariance, the model is written as q $\sim$ N(0, I), p $\sim$ N($Δ$, I), with linear features, where $Δ$ is a mean vector. The variational estimator is the empirical Kullback-Leibler (KL) log-normalized fit with a squared L2-penalty on its nonconstant coefficient, and the spectral estimator recently introduced in [1] replaces a single variational…

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A flexible wrapped Lindley-type distribution for angular data modelling

面向角度数据的柔性缠绕Lindley型分布

Flexible distributions for modelling angular data have received considerable attention in recent years, with ongoing work extending existing circular models to provide greater flexibility in capturing diverse angular behaviours. In this paper, we introduce and study the w3PL distribution, a circular model obtained by extending the wrapped Lindley distribution by incorporating two additional shape parameters. The proposed generalisation increases flexibility in modelling…

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Continuous-Time Bayesian Networks with Structured Shrinkage Priors for Modelling Multimorbidity Trajectories in Large-Scale Electronic Health Records

带结构化收缩先验的连续时间贝叶斯网络:大规模电子健康记录中的多病轨迹建模

Multiple long-term conditions (MLTCs) arise through complex, time-dependent interactions among diseases, yet existing methods often struggle to jointly model disease progression, multimorbidity networks, and high-dimensional risk factors. We propose a structured Bayesian continuous-time Bayesian network (CTBN) framework for learning directed disease-dependency networks from longitudinal electronic health records. The model allows disease transition intensities to depend on…

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Outlier detection in state-space models using mean-shift penalisation

利用均值偏移惩罚检测状态空间模型中的异常值

State-space models (SSMs) provide a flexible framework for modelling time series data, but their reliance on Gaussian error assumptions makes them highly sensitive to outliers. We propose a robust estimation method, ROAMS, that mitigates the influence of additive outliers by introducing shift parameters at each timepoint in the observation equation of the SSM. These parameters allow the model to attribute non-zero shifts to outliers while leaving clean observations…

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Sparse Tree-Based Aggregation for Time Series Regressions

时间序列回归的稀疏树状聚合

High-dimensional time series regressions are often regularized to produce sparse coefficients. We show that temporal aggregation provides a powerful alternative to reduce dimensionality in high-order autoregressions and mixed-frequency regressions. To this end, we propose StarTime (Sparse Tree-based Aggregation for Time Series), a convex penalization method that uses a temporal tree to arrange lags hierarchically from high to low frequency. StarTime then flexibly selects…

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Transfert learning and adaptive LASSO quantile

迁移学习与自适应 LASSO 分位数回归

We propose for a quantile regression an estimation method for transferring knowledge using two $L_1$ penalties based on an estimator obtained from a source database. The proposed transfer learning estimator satisfies the properties of consistency and sparsity. Its convergence rate and asymptotic behavior are studied in several scenarios. This knowledge transfer results in a shorter computation time than that of the standard adaptive LASSO estimator. Another advantage of our…

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