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靶向深度生存对比：神经网络下处理特定生存收益的有效推断AI 解读

Neural survival models are increasingly asked to support counterfactual claims---how much a treatment would change survival in a population---rather than only prognostic risk scores. Answering such questions from observational data requires valid inference for treatment-specific survival contrasts under confounding and covariate-dependent censoring, targets for which standard deep survival estimators are biased and provide no honest uncertainty. We propose Targeted Deep…

无序对空间上的协方差核：理论与网络数据应用AI 解读

Many scientific problems are relational: the quantity of interest is a connection between two objects, while information about similarity is available for the objects themselves. We develop a covariance framework for unordered relationships that transfers object-level geometry to the relations they form while preserving endpoint identity and invariance to ordering. Building on symmetric pairwise-kernel representations, we develop theory for the loop-free domains used in…

一般平滑模型中选择平滑参数的结构化割线方法AI 解读

General smooth models replace parameters of a regular likelihood with additive models. The models can include parametric terms, Gaussian random effects, and smooth functions of covariates. The latter are parameterized via a reduced-rank spline basis and regularized via weighted quadratic penalties placed on the basis coefficients. Estimates for these weights (i.e., smoothing parameters) can be obtained by optimizing the Laplace-approximate Bayesian marginal likelihood.…

分类处理下个体化处理规则的部分识别学习AI 解读

We develop a partial identification learning framework for individualized treatment rules (ITRs) with categorical treatments, outcomes, and instrumental variables. Rather than relying on strong causal assumptions required for point identification, our framework leverages causal bounds to characterize the optimal treatment decision. Existing methods for ITR optimization under partial identification are largely restricted to binary treatment settings and the bounds derived by…

鞅 R 学习器：事件时间结果的时变异质性治疗效应估计AI 解读

Biological research and clinical evidence suggest that treatment response may vary substantially along characteristics, such as comorbidities, genetic variants, environmental, or socio-economic factors. Future precision medicine requires accurate assessment of heterogeneous treatment effects (HTE) to guide optimal clinical decisions at the individual level. We introduce a functional score framework that extends the traditional estimating equations for survival data to…

静态支付意愿何时产生误导？动态特征价值评估框架AI 解读

Many policy counterfactuals depend on how consumers value product attributes such as sugar, caffeine, alcohol, or emissions. Standard hedonic and differentiated-products models typically impose time-separable preferences. But when attributes are habit forming, current consumption can shift future marginal valuations, so static willingness-to-pay may be insufficient for policy counterfactuals. I develop a nonparametric revealed-preference framework for dynamic hedonic…

诊断测试与人工智能医疗器械的因果评估：效应修饰与信息增强决策AI 解读

Diagnostic medical tests and devices provide useful information for evaluating the potential benefits and risks of therapeutic treatments. However, unlike treatments, their impact on health outcomes is generally indirect because measuring diagnostic information typically does not itself affect patient outcomes, which complicates evaluation of their effectiveness. In this work, we develop a causal inference approach for evaluating diagnostic tests by distinguishing…

协变量分布迁移下连续处理效应的因果推广AI 解读

Average dose-response functions are widely used to summarize causal effects of continuous treatments, but most existing methods assume that the observed sample represents the target population. We study a covariate-shift setting in which covariates, treatment, and outcome are observed in a labelled source sample, while only covariates are observed in the target sample. We develop a two-sample local polynomial regression framework based on pseudo-outcomes that use source…

删失选择模型的分布回归方法AI 解读

We develop a distribution regression model with a censored selection rule, offering a semi-parametric generalization of the Heckman selection model. Our approach applies to the entire distribution, extending beyond the mean or median, accommodates non-Gaussian error structures, and allows for heterogeneous effects of covariates on both the selection and outcome distributions. By employing a censored selection rule, our model can uncover richer selection patterns according to…

Lasso选择后Cox模型的模型化自助法推断AI 解读

Inference after variable selection in Cox regression is difficult because simple Wald-type intervals after selection can have poor finite-sample conditional coverage. We study a model-based bootstrap for inference after Cox-Lasso variable selection. The Cox-Lasso is fitted once to the original data to select a set of variables, after which an unpenalized Cox model is fitted using only those variables. Bootstrap samples are generated from a semiparametric plug-in Cox model…

个体化治疗效应预测校准的非参数评估AI 解读

An important aspect of the performance of algorithms that predict individualized treatment effects (ITE) is moderate calibration, i.e., the average treatment effect among individuals with predicted treatment effect of z being equal to z. The assessment of moderate calibration is challenging on two fronts: counterfactual responses are unobserved, and quantifying the conditional response function for models that generate continuous predicted values requires regularization.…

实验设计的极限：超越低维的协变量平衡AI 解读

We study how fast experimental designs can approach the semiparametric efficiency bound in finite samples, as measured by the excess variance of unadjusted treatment effect estimation. We prove an impossibility theorem: under weak conditions, no design can approach the variance bound uniformly over smooth outcome models unless covariate dimension $d \ll \log n$. Even in experiments with thousands of units, this permits only a handful of covariates. Motivated by this, we…

后验漂移与潜在隐藏混杂下的试验证据迁移AI 解读

Randomized trials provide internally valid treatment-effect evidence, but trial participants may not represent the target population. In contrast, observational studies are often closer to the target population, but their treatment assignment may be affected by possible hidden confounding. We develop a robust posterior-drift framework for estimating the average treatment effect in an observational target population when exact conditional-effect transportability may fail. The…

森林核平衡权重：由结局引导的因果推断特征AI 解读

While balancing covariates between groups is central for observational causal inference, selecting which features to balance remains a challenging problem. Kernel balancing is a promising approach that first estimates a kernel that captures similarity across units and then balances a (possibly low-dimensional) summary of that kernel, indirectly learning important features to balance. In this paper, we propose forest kernel balancing, which leverages the underappreciated fact…

时变调节效应的选择后推断AI 解读

Causal effect moderation investigates how the effect of interventions (or treatments) on outcome variables changes based on observed characteristics of individuals, known as potential effect moderators. With advances in data collection, datasets containing many observed features as potential moderators have become increasingly common. High-dimensional analyses often lack interpretability, with important moderators masked by noise, while low-dimensional, marginal analyses…

目标点处的条件随机占优检验AI 解读

This paper introduces a test for conditional stochastic dominance between two distributions at prespecified values of a conditioning covariate, referred to as target points. The test uses a one-sided Kolmogorov--Smirnov statistic computed from induced order statistics, the outcomes attached to the conditioning observations closest to the target point, and compares it to a critical value that, given the number of neighbors, requires no resampling, kernel smoothing, or…

高维线性回归的经验贝叶斯方法：矩估计与次线性样本复杂度AI 解读

We study empirical Bayes estimation of the prior in high-dimensional linear regression $\mathbf{y}=\mathbf{X}\mathbfβ+\mathbf{\varepsilon}$, where the regression coefficients are drawn independently from an unknown sub-Gaussian prior. In contrast to the sequence model, the design matrix couples the latent coefficients, so that recovering the prior requires deconvolving it from both the noise and copies of itself. We introduce the \emph{Empirical Bayes Method of Moments}…

分位数限制、揭示排序与多项选择的边界AI 解读

This paper analyzes when choice probabilities reveal rankings of deterministic utility indices in semiparametric discrete choice models. It begins with binary choice, where quantile thresholds guarantee ranking recovery, and shows that such thresholds can arise either from behavioral departures from utility maximization (e.g., limited attention) under exchangeable unobservables, or from non-exchangeable unobservables under standard utility maximization. These behavioral and…

NP-LEAP：借用历史数据的非参数潜在可交换性先验AI 解读

Bayesian dynamic borrowing (BDB) methods leverage historical data to reduce treatment effect uncertainty, yet existing approaches rely on parametric outcome models susceptible to misspecification. We propose the nonparametric latent exchangeability prior (NP-LEAP), an outcome-agnostic, assumption-lean framework to borrow information from historical data. The NP-LEAP performs individual-level exchangeability assessment, inducing Bayesian model averaging over all possible…

生存结局治疗效应的随机化推断AI 解读

The log-rank test and Kaplan--Meier plot are standard tools for analyzing time-to-event data in randomized clinical trials, yet neither provides a summary of the magnitude of the treatment effect. Practitioners typically fill this gap by reporting a hazard ratio from a Cox proportional-hazards model or an acceleration factor from an accelerated failure time (AFT) model, but both require assumptions beyond those needed for the log-rank test or Kaplan--Meier estimator. We…

高维矩阵值时间序列的时空自回归AI 解读

Motivated by predicting intraday trading volume curves, we consider two spatio-temporal autoregressive models for matrix time series, in which each column may represent daily trading volume curve of one asset, and each row captures synchronized 5-minute volume intervals across multiple assets. While traditional matrix time series focus mainly on temporal evolution, our approach incorporates both spatial and temporal dynamics, enabling simultaneous analysis of interactions…

测量误差下的树聚合组成数据回归AI 解读

Compositional covariates in microbiome studies are often measured with error and organized by a biological hierarchy. Tree aggregation can improve multiresolution interpretation, but it also combines leaf-level errors into correlated contamination whose scale varies across the hierarchy. Existing tree aggregation and compositional measurement-error correction do not combine directly in redundant tree coordinates because a generic positive semidefinite projection can make the…

个体与整群随机试验中存活期间目标量的双重稳健估计AI 解读

Randomized trials in chronic disease settings often measure treatment benefit through recurrent non-fatal events that are truncated by death, where conventional summaries either discard recurrences, conflate the treatment effect with survival, or treat death as censoring and forfeit a causal interpretation. While-alive estimands measure event burden per unit time alive, but doubly robust estimation for the exposure-weighted while-alive rate remains undeveloped, particularly…

GFCM：面向因果发现的尾部敏感混合类型条件独立检验AI 解读

Constraint-based causal discovery like PC and FCI depends on its conditional independence test. Partial correlation and the Generalised Covariance Measure (GCM) detect only the conditional covariance of residuals, so they miss dependence in the mean's nonlinear part, the scale, and the tails. Tests that detect more are biased inside PC, not scalable, only continuous, or not aimed at the tails. Our Generalised Feature Covariance Measure (GFCM) is valid, sensitive beyond…