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用于骨质疏松多组学生物标志物筛选与药物发现的稳健核机器回归AI 解读

Many statistical machine approaches could ultimately highlight novel features of the etiology of complex diseases by analyzing multi-omics data. However, they are sensitive to some deviations in distribution when the observed samples are potentially contaminated with adversarial corrupted outliers (e.g., a fictional data distribution). Likewise, statistical advances lag in supporting comprehensive data-driven analyses of complex multi-omics data integration. We propose a…

存在干扰时的平均直接与间接因果效应AI 解读

We propose a definition for the average indirect effect of a binary treatment in the potential outcomes model for causal inference under cross-unit interference. Our definition is analogous to the standard definition of the average direct effect, and can be expressed without needing to compare outcomes across multiple randomized experiments. We show that the proposed indirect effect satisfies a decomposition theorem whereby, in a Bernoulli trial, the sum of the average…

贝叶斯非参数因果推断：方法与理由AI 解读

Spurred on by recent successes in causal inference competitions, Bayesian nonparametric (and high-dimensional) methods have recently seen increased attention in the causal inference literature. In this paper, we present a comprehensive overview of Bayesian nonparametric applications to causal inference. Our aims are to (i) introduce the fundamental Bayesian nonparametric toolkit; (ii) discuss how to determine which tool is most appropriate for a given problem; and (iii) show…

因果图模型中的高效最低成本调整集AI 解读

We study the selection of adjustment sets for estimating the interventional mean under an individualized treatment rule. We assume a non-parametric causal graphical model with, possibly, hidden variables and at least one adjustment set comprised of observable variables. Moreover, we assume that observable variables have positive costs associated with them. We define the cost of an observable adjustment set as the sum of the costs of the variables that comprise it. We show…

工具变量下的因果中介分析AI 解读

Mediation analysis is a strategy for understanding the mechanisms by which treatments or interventions affect later outcomes. Mediation analysis is frequently applied in randomized trial settings, but typically assumes: a) that randomized assignment is the exposure of interest as opposed to actual take-up of the intervention, and b) no unobserved confounding of the mediator-outcome relationship. In contrast to the rich literature on instrumental variable (IV) methods to…

两个二元中介变量下分解效应的锐利非参数界AI 解读

In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathway between the randomized treatment and the outcome. In the setting with two sequential mediators, there are a variety of decompositions of the total risk difference into mediation effects. We derive sharp and valid bounds for a number of mediation effects in the setting of two sequential mediators…

收缩与稀疏估计的贝叶斯方法AI 解读

In all areas of human knowledge, datasets are increasing in both size and complexity, creating the need for richer statistical models. This trend is also true for economic data, where high-dimensional and nonlinear/nonparametric inference is the norm in several fields of applied econometric work. The purpose of this paper is to introduce the reader to the world of Bayesian model determination, by surveying modern shrinkage and variable selection algorithms and methodologies.…

成对比较中的排序与选择：引文分析的经验贝叶斯方法AI 解读

We study the Stigler model of citation flows among journals adapting the pairwise comparison model of Bradley and Terry to do ranking and selection of journal influence based on nonparametric empirical Bayes procedures. Comparisons with several other rankings are made.

两条交叉生存曲线的非参数统计方法AI 解读

In comparative research on time-to-event data for two groups, when two survival curves cross each other, it may be difficult to use the log-rank test and hazard ratio (HR) to properly assess the treatment benefit. Our aim was to identify a method for evaluating the treatment benefits for two groups in the above situation. We quantified treatment benefits based on an intuitive measure called the area between two survival curves (ABS), which is a robust measure of treatment…

时变非线性时间序列回归的筛法同时推断AI 解读

In this paper, we consider the time-inhomogeneous nonlinear time series regression for a general class of locally stationary time series. On one hand, we propose sieve nonparametric estimators for the time-varying regression functions which can achieve the min-max optimal rate. On the other hand, we develop a unified simultaneous inferential theory which can be used to conduct both structural and exact form testings on the functions. Our proposed statistics are powerful even…

高维数据中混杂变量选择的目标化方法AI 解读

We consider the problem of selecting confounders for adjustment from a potentially large set of covariates, when estimating a causal effect. Recently, the high-dimensional Propensity Score (hdPS) method was developed for this task; hdPS ranks potential confounders by estimating an importance score for each variable and selects the top few variables. However, this ranking procedure is limited: it requires all variables to be binary. We propose an extension of the hdPS to…

合成控制方法的假设AI 解读

Synthetic control (SC) methods have been widely applied to estimate the causal effect of large-scale interventions, e.g., the state-wide effect of a change in policy. The idea of synthetic controls is to approximate one unit's counterfactual outcomes using a weighted combination of some other units' observed outcomes. The motivating question of this paper is: how does the SC strategy lead to valid causal inferences? We address this question by re-formulating the causal…

R 包 knnwtsim：使用定制相似度的非参数预测AI 解读

The R package knnwtsim provides functions to implement k nearest neighbors (KNN) forecasting using a similarity metric tailored to the forecasting problem of predicting future observations of a response series where recent observations, seasonal or periodic patterns, and the values of one or more exogenous predictors all have predictive value in forecasting new response points. This paper will introduce the similarity measure of interest, and the functions in knnwtsim used…

群组层面处理效应异质性下的时变因果效应调节评估AI 解读

The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands of decision points. MRTs have motivated a new class of causal estimands, termed "causal excursion effects", for which semiparametric inference can be conducted via a weighted, centered least squares criterion (Boruvka et al., 2018). Existing methods assume…

半参数离散选择模型的高效反事实估计：一则方法补充AI 解读

I suggest an enhancement of the procedure of Chiong, Hsieh, and Shum (2017) for calculating bounds on counterfactual demand in semiparametric discrete choice models. Their algorithm relies on a system of inequalities indexed by cycles of a large number $M$ of observed markets and hence seems to require computationally infeasible enumeration of all such cycles. I show that such enumeration is unnecessary because solving the "fully efficient" inequality system exploiting…

反事实情景中因果人群分布的非参数估计AI 解读

In causality, estimating the effect of a treatment without confounding inference remains a major issue because requires to assess the outcome in both case with and without treatment. Not being able to observe simultaneously both of them, the estimation of potential outcome remains a challenging task. We propose an innovative approach where the problem is reformulated as a missing data model. The aim is to estimate the hidden distribution of \emph{causal populations}, defined…

通过敏感性曲线实现再中心化影响函数回归AI 解读

This paper proposes an empirical method to implement the recentered influence function (RIF) regression of Firpo, Fortin and Lemieux (2009), a relevant method to study the effect of covariates on many statistics beyond the mean. In empirically relevant situations where the influence function is not available or difficult to compute, we suggest to use the \emph{sensitivity curve} (Tukey, 1977) as a feasible alternative. This may be computationally cumbersome when the sample…

理解基于有效影响函数的统计学习AI 解读

Evaluation of treatment effects and more general estimands is typically achieved via parametric modelling, which is unsatisfactory since model misspecification is likely. Data-adaptive model building (e.g. statistical/machine learning) is commonly employed to reduce the risk of misspecification. Naive use of such methods, however, delivers estimators whose bias may shrink too slowly with sample size for inferential methods to perform well, including those based on the…

利用机器学习分析和分类交通事故伤害严重程度AI 解读

Causal analysis and classification of injury severity applying non-parametric methods for traffic crashes has received limited attention. This study presents a methodological framework for causal inference, using Granger causality analysis, and injury severity classification of traffic crashes, occurring on interstates, with different machine learning techniques including decision trees (DT), random forest (RF), extreme gradient boosting (XGBoost), and deep neural network…

倾向得分分析中的选择后推断AI 解读

Selective inference (post-selection inference) is a methodology that has attracted much attention in recent years in the fields of statistics and machine learning. Naive inference based on data that are also used for model selection tends to show an overestimation, and so the selective inference conditions the event that the model was selected. In this paper, we develop selective inference in propensity score analysis with a semiparametric approach, which has become a…

天气预报精度的空间相关：函数型时间序列方法AI 解读

A functional time series approach is proposed for investigating spatial correlation in daily maximum temperature forecast errors for 111 cities spread across the U.S. The modelling of spatial correlation is most fruitful for longer forecast horizons, and becomes less relevant as the forecast horizon shrinks towards zero. For 6-day-ahead forecasts, the functional approach uncovers interpretable regional spatial effects, and captures the higher variance observed in inland…

回归折点设计中的优化推断AI 解读

We propose a method to remedy finite sample coverage problems and improve upon the efficiency of commonly employed procedures for the construction of nonparametric confidence intervals in regression kink designs. The proposed interval is centered at the half-length optimal, numerically obtained linear minimax estimator over distributions with Lipschitz constrained conditional mean function. Its construction ensures excellent finite sample coverage and length properties which…

时变参数调制的周期变星模型AI 解读

Many astrophysical phenomena are time-varying, in the sense that their brightness change over time. In the case of periodic stars, previous approaches assumed that changes in period, amplitude, and phase are well described by either parametric or piecewise-constant functions. With this paper, we introduce a new mathematical model for the description of the so-called modulated light curves, as found in periodic variable stars that exhibit smoothly time-varying parameters such…

基于连续排序概率评分的预测学习AI 解读

Combination and aggregation techniques can significantly improve forecast accuracy. This also holds for probabilistic forecasting methods where predictive distributions are combined. There are several time-varying and adaptive weighting schemes such as Bayesian model averaging (BMA). However, the quality of different forecasts may vary not only over time but also within the distribution. For example, some distribution forecasts may be more accurate in the center of the…