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Restricted Mean Survival Time Estimation Using Bayesian Nonparametric Dependent Mixture Models

利用贝叶斯非参数依赖混合模型估计限制平均生存时间

Restricted mean survival time (RMST) is an intuitive summary statistic for time-to-event random variables, and can be used for measuring treatment effects. Compared to hazard ratio, its estimation procedure is robust against the non-proportional hazards assumption. We propose nonparametric Bayeisan (BNP) estimators for RMST using a dependent stick-breaking process prior mixture model that adjusts for mixed-type covariates. The proposed Bayesian estimators can yield both…

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A nonparametric doubly robust test for a continuous treatment effect

连续处理效应的非参数双重稳健检验

The vast majority of literature on evaluating the significance of a treatment effect based on observational data has been confined to discrete treatments. These methods are not applicable to drawing inference for a continuous treatment, which arises in many important applications. To adjust for confounders when evaluating a continuous treatment, existing inference methods often rely on discretizing the treatment or using (possibly misspecified) parametric models for the…

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On the estimation of locally stationary functional time series

局部平稳函数型时间序列的估计

This study develops an asymptotic theory for estimating the time-varying characteristics of locally stationary functional time series (LSFTS). We investigate a kernel-based method to estimate the time-varying covariance operator and the time-varying mean function of an LSFTS. In particular, we derive the convergence rate of the kernel estimator of the covariance operator and associated eigenvalue and eigenfunctions and establish a central limit theorem for the kernel-based…

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Identification and Estimation of Production Function with Unobserved Heterogeneity

含未观测异质性的生产函数识别与估计

This paper examines the nonparametric identifiability of production functions, considering firm heterogeneity beyond Hicks-neutral technology terms. We propose a finite mixture model to account for unobserved heterogeneity in production technology and productivity growth processes. Our analysis demonstrates that the production function for each latent type can be nonparametrically identified using four periods of panel data, relying on assumptions similar to those employed…

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Context-Dependent Heterogeneous Preferences: A Comment on Barseghyan and Molinari (2023)

依赖情境的异质性偏好:对 Barseghyan 与 Molinari(2023)的评论

Barseghyan and Molinari (2023) give sufficient conditions for semi-nonparametric point identification of parameters of interest in a mixture model of decision-making under risk, allowing for unobserved heterogeneity in utility functions and limited consideration. A key assumption in the model is that the heterogeneity of risk preferences is unobservable but context-independent. In this comment, we build on their insights and present identification results in a setting where…

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Tuning Parameter-Free Nonparametric Density Estimation from Tabulated Summary Data

基于汇总表数据的无调参非参数密度估计

Administrative data are often easier to access as tabulated summaries than in the original format due to confidentiality concerns. Motivated by this practical feature, we propose a novel nonparametric density estimation method from tabulated summary data based on maximum entropy and prove its strong uniform consistency. Unlike existing kernel-based estimators, our estimator is free from tuning parameters and admits a closed-form density that is convenient for post-estimation…

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Sharp symbolic nonparametric bounds for measures of benefit in observational and imperfect randomized studies with ordinal outcomes

有序结果下观察性研究与不完全随机试验获益指标的尖锐非参数界

The probability of benefit is a valuable and important measure of treatment effect, which has advantages over the average treatment effect. Particularly for an ordinal outcome, it has a better interpretation and can make apparent different aspects of the treatment impact. Unfortunately, this measure, and variations of it, are not identifiable even in randomized trials with perfect compliance. There is, for this reason, a long literature on nonparametric bounds for…

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A Guide to Regression Discontinuity Designs in Medical Applications

医学应用中的回归不连续设计指南

We present a practical guide for the analysis of regression discontinuity (RD) designs in biomedical contexts. We begin by introducing key concepts, assumptions, and estimands within both the continuity-based framework and the local randomization framework. We then discuss modern estimation and inference methods within both frameworks, including approaches for bandwidth or local neighborhood selection, optimal treatment effect point estimation, and robust bias-corrected…

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Grenander-type Density Estimation under Myerson Regularity

Myerson 正则性约束下的 Grenander 型密度估计

This study presents a novel approach to the density estimation of private values from second-price auctions, diverging from the conventional use of smoothing-based estimators. We introduce a Grenander-type estimator, constructed based on a shape restriction in the form of a convexity constraint. This constraint corresponds to the renowned Myerson regularity condition in auction theory, which is equivalent to the concavity of the revenue function for selling the auction item.…

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A Causal Inference Framework for Leveraging External Controls in Hybrid Trials

混合试验中利用外部对照的因果推断框架

We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE). Through the development of a formal causal inference framework, we outline sufficient causal assumptions about the exchangeability between the internal and external controls to identify the ATE and establish the connection to a novel graphical…

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Efficient Semiparametric Estimation of Average Treatment Effects Under Covariate Adaptive Randomization

协变量自适应随机化下平均处理效应的半参数有效估计

Experiments that use covariate adaptive randomization (CAR) are commonplace in applied economics and other fields. In such experiments, the experimenter first stratifies the sample according to observed baseline covariates and then assigns treatment randomly within these strata so as to achieve balance according to pre-specified stratum-specific target assignment proportions. In this paper, we compute the semiparametric efficiency bound for estimating the average treatment…

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Semiparametrically Optimal Cointegration Test

半参数最优协整检验

This paper aims to address the issue of semiparametric efficiency for cointegration rank testing in finite-order vector autoregressive models, where the innovation distribution is considered an infinite-dimensional nuisance parameter. Our asymptotic analysis relies on Le Cam's theory of limit experiment, which in this context takes the form of Locally Asymptotically Brownian Functional (LABF). By leveraging the structural version of LABF, an Ornstein-Uhlenbeck experiment, we…

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Causal Inference with Unmeasured Confounding from Nonignorable Missing Outcomes

不可忽略结局缺失与未测混杂下的因果推断

Observational studies are the primary source of data for causal inference, but it is challenging when existing unmeasured confounding. Missing data problems are also common in observational studies. How to obtain the causal effects from the nonignorable missing data with unmeasured confounding is a challenge. In this paper, we consider that how to obtain complier average causal effect with unmeasured confounding from the nonignorable missing outcomes. We propose an auxiliary…

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Bayesian sensitivity analysis for a missing data model

缺失数据模型的贝叶斯敏感性分析

In causal inference, sensitivity analysis is important to assess the robustness of study conclusions to key assumptions. We perform sensitivity analysis of the assumption that missing outcomes are missing completely at random. We follow a Bayesian approach, which is nonparametric for the outcome distribution and can be combined with an informative prior on the sensitivity parameter. We give insight in the posterior and provide theoretical guarantees in the form of…

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Robust Inference for Causal Mediation Analysis of Recurrent Event Data

重复事件数据因果中介分析的稳健推断

Recurrent events, including cardiovascular events, are commonly observed in biomedical studies. Researchers must understand the effects of various treatments on recurrent events and investigate the underlying mediation mechanisms by which treatments may reduce the frequency of recurrent events are crucial. Although causal inference methods for recurrent event data have been proposed, they cannot be used to assess mediation. This study proposed a novel methodology of causal…

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Proximal Causal Learning of Conditional Average Treatment Effects

条件平均处理效应的近端因果学习

Efficiently and flexibly estimating treatment effect heterogeneity is an important task in a wide variety of settings ranging from medicine to marketing, and there are a considerable number of promising conditional average treatment effect estimators currently available. These, however, typically rely on the assumption that the measured covariates are enough to justify conditional exchangeability. We propose the P-learner, motivated by the R- and DR-learner, a tailored…

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A Bayesian Non-parametric Approach for Causal Mediation with a Post-treatment Confounder

存在处理后混杂变量时因果中介分析的贝叶斯非参数方法

We propose a new Bayesian non-parametric (BNP) method for estimating the causal effects of mediation in the presence of a post-treatment confounder. We specify an enriched Dirichlet process mixture (EDPM) to model the joint distribution of the observed data (outcome, mediator, post-treatment confounders, treatment, and baseline confounders). The proposed BNP model allows more confounder-based clusters than clusters for the outcome and mediator. For identifiability, we use…

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Bayesian Nonparametric Common Atoms Regression for Generating Synthetic Controls in Clinical Trials

用于构建临床试验合成对照组的贝叶斯非参数共同原子回归

The availability of electronic health records (EHR) has opened opportunities to supplement increasingly expensive and difficult to carry out randomized controlled trials (RCT) with evidence from readily available real world data. In this paper, we use EHR data to construct synthetic control arms for treatment-only single arm trials. We propose a novel nonparametric Bayesian common atoms mixture model that allows us to find equivalent population strata in the EHR and the…

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Signature asymptotics, empirical processes, and optimal transport

路径签名渐近理论、经验过程与最优传输

Rough path theory provides one with the notion of signature, a graded family of tensors which characterise, up to a negligible equivalence class, and ordered stream of vector-valued data. In the last few years, use of the signature has gained traction in time-series analysis, machine learning , deep learning and more recently in kernel methods. In this article, we lay down the theoretical foundations for a connection between signature asymptotics, the theory of empirical…

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Bayesian Modeling of TVP-VARs Using Regression Trees

利用回归树对时变参数向量自回归模型进行贝叶斯建模

In light of widespread evidence of parameter instability in macroeconomic models, many time-varying parameter (TVP) models have been proposed. This paper proposes a nonparametric TVP-VAR model using Bayesian additive regression trees (BART) that models the TVPs as an unknown function of effect modifiers. The novelty of this model arises from the fact that the law of motion driving the parameters is treated nonparametrically. This leads to great flexibility in the nature and…

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Simultaneous predictive bands for functional time series using minimum entropy sets

利用最小熵集合构造函数型时间序列同时预测带

Functional Time Series are sequences of dependent random elements taking values on some functional space. Most of the research on this domain is focused on producing a predictor able to forecast the value of the next function having observed a part of the sequence. For this, the Autoregresive Hilbertian process is a suitable framework. We address here the problem of constructing simultaneous predictive confidence bands for a stationary functional time series. The method is…

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Controlling for Latent Confounding with Triple Proxies

利用三重代理变量控制潜在混杂

We present new results for nonparametric identification of causal effects using noisy proxies for unobserved confounders. Our approach builds on the results of \citet{Hu2008} who tackle the problem of general measurement error. We call this the `triple proxy' approach because it requires three proxies that are jointly independent conditional on unobservables. We consider three different choices for the third proxy: it may be an outcome, a vector of treatments, or a…

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Efficient estimation of weighted cumulative treatment effects by double/debiased machine learning

用双重/去偏机器学习有效估计加权累积治疗效应

In empirical studies with time-to-event outcomes, investigators often leverage observational data to conduct causal inference on the effect of exposure when randomized controlled trial data is unavailable. Model misspecification and lack of overlap are common issues in observational studies, and they often lead to inconsistent and inefficient estimators of the average treatment effect. Estimators targeting overlap weighted effects have been proposed to address the challenge…

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On the pitfalls of Gaussian likelihood scoring for causal discovery

高斯似然评分用于因果发现的陷阱

We consider likelihood score-based methods for causal discovery in structural causal models. In particular, we focus on Gaussian scoring and analyze the effect of model misspecification in terms of non-Gaussian error distribution. We present a surprising negative result for Gaussian likelihood scoring in combination with nonparametric regression methods.

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