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Enhancing the Merger Simulation Toolkit with ML/AI

用机器学习与人工智能扩展并购模拟工具

This paper develops a flexible approach to predict the price effects of horizontal mergers using ML/AI methods. While standard merger simulation techniques rely on restrictive assumptions about firm conduct, we propose a data-driven framework that relaxes these constraints when rich market data are available. We develop and identify a flexible nonparametric model of supply that nests a broad range of conduct models and cost functions. To overcome the curse of dimensionality,…

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At the edge of Donsker's Theorem: Asymptotics of multiscale scan statistics

Donsker 定理的边界:多尺度扫描统计量的渐近理论

For nonparametric inference about a function, multiscale testing procedures resolve the need for bandwidth selection and achieve asymptotically optimal detection performance against a broad range of alternatives. However, critical values strongly depend on the noise distribution, and we argue that existing methods are either statistically infeasible, or asymptotically sub-optimal. To address this methodological challenge, we show how to develop a feasible multiscale test via…

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Distributed lag non-linear models with Laplacian-P-splines for analysis of spatially structured time series

用于空间结构时间序列的拉普拉斯 P 样条分布滞后非线性模型

Distributed lag non-linear models (DLNM) have gained popularity for modeling nonlinear lagged relationships between exposures and outcomes. When applied to spatially referenced data, these models must account for spatial dependence, a challenge that has yet to be thoroughly explored within the penalized DLNM framework. This gap is mainly due to the complex model structure and high computational demands, particularly when dealing with large spatio-temporal datasets. To…

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Kernel-based estimators for functional causal effects

函数型因果效应的核估计方法

We propose causal effect estimators based on empirical Fréchet means and operator-valued kernels, tailored to functional data spaces. These methods address the challenges of high-dimensionality, sequential ordering, and model complexity while preserving robustness to treatment misspecification. Using structural assumptions, we obtain compact representations of potential outcomes, enabling scalable estimation of causal effects over time and across covariates. We provide both…

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Variable Selection in Functional Linear Cox Model

函数线性Cox模型中的变量选择

Modern biomedical studies frequently collect complex, high-dimensional physiological signals using wearables and sensors along with time-to-event outcomes, making efficient variable selection methods crucial for interpretation and improving the accuracy of survival models. We propose a novel variable selection method for a functional linear Cox model with multiple functional and scalar covariates measured at baseline. We utilize a spline-based semiparametric estimation…

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Function-on-function Differential Regression

函数对函数微分回归

Function-on-function regression has been a topic of substantial interest due to its broad applicability, where the relation between functional predictor and response is concerned. In this article, we propose a new framework for modeling the regression mapping that extends beyond integral type, motivated by the prevalence of physical phenomena governed by differential relations, which is referred to as function-on-function differential regression. However, a key challenge…

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Semiparametric Weighted Spline Regression (SWSR) in Confirmatory Clinical Trials with Time-Varying Placebo Effects

时变安慰剂效应确证性临床试验中的半参数加权样条回归

In confirmatory Phase 3 clinical trials with recruitment over the years, the underlying placebo effect may follow an unknown temporal trend. Taking a clinical trial on Hidradenitis Suppurativa (HS) as an example, fluctuations or variabilities are common in HS-related endpoints, mainly due to the natural disease characteristics, variations of evaluation from different physicians, and standard of care evolvement. The adjustment of time-varying placebo effects receives some…

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Kernel $ε$-Greedy for Multi-Armed Bandits with Covariates

带协变量的多臂老虎机核 ε-贪心策略

We consider the $ε$-greedy strategy for the multi-arm bandit with covariates (MABC) problem, where the mean reward functions are assumed to lie in a reproducing kernel Hilbert space (RKHS). We propose to estimate the unknown mean reward functions using an online weighted kernel ridge regression estimator, and show the resultant estimator to be consistent under appropriate decay rates of the exploration probability sequence, $\{ε_t\}_t$, and regularization parameter, $\{λ_t\}_t$…

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Projection Pursuit Density Ratio Estimation

投影寻踪密度比估计

Density ratio estimation (DRE) is a paramount task in machine learning, for its broad applications across multiple domains, such as covariate shift adaptation, causal inference, independence tests and beyond. Parametric methods for estimating the density ratio possibly lead to biased results if models are misspecified, while conventional non-parametric methods suffer from the curse of dimensionality when the dimension of data is large. To address these challenges, in this…

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Nested Nonparametric Instrumental Variable Regression

嵌套非参数工具变量回归

Several causal parameters in short panel data models are functionals of a nested nonparametric instrumental variable regression (nested NPIV). Recent examples include mediated, time varying, and long term treatment effects identified using proxy variables. In econometrics, examples arise in triangular simultaneous equations and hedonic price systems. However, it appears that explicit mean square convergence rates for nested NPIV are unknown, preventing inference on some of…

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Propensity weighting plus adjustment in proportional hazards model is not doubly robust

比例风险模型中的倾向加权加回归调整不具一般双重稳健性

Recently, it has become common for applied works to combine commonly used survival analysis modeling methods, such as the multivariable Cox model and propensity score weighting, with the intention of forming a doubly robust estimator of an exposure effect hazard ratio that is unbiased in large samples when either the Cox model or the propensity score model is correctly specified. This combination does not, in general, produce a doubly robust estimator, even after regression…

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Improve the Precision of Area Under the Curve Estimation for Recurrent Events Through Covariate Adjustment

通过协变量调整提高复发事件曲线下面积估计精度

The area under the curve (AUC) of the mean cumulative function (MCF) has recently been introduced as a novel estimand for evaluating treatment effects in recurrent event settings, offering an alternative to the commonly used Lin-Wei-Yang-Ying (LWYY) model. The AUC of the MCF provides a clinically interpretable summary measure that captures the overall burden of disease progression, regardless of whether the proportionality assumption holds. To improve the precision of the…

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PUATE: Efficient Average Treatment Effect Estimation from Treated (Positive) and Unlabeled Units

PUATE:处理组与未标记个体的高效平均处理效应估计

The estimation of average treatment effects (ATEs), defined as the difference in expected outcomes between treatment and control groups, is a central topic in causal inference. This study develops semiparametric efficient estimators for ATE in a setting where only a treatment group and an unlabeled group, consisting of units whose treatment status is unknown, are observed. This scenario constitutes a variant of learning from positive and unlabeled data (PU learning) and can…

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Adaptive Block-Based Change-Point Detection for Sparse Spatially Clustered Data with Applications in Remote Sensing Imaging

稀疏空间聚集数据的自适应分块变点检测及遥感应用

We present a non-parametric change-point detection approach to detect potentially sparse changes in a time series of high-dimensional observations or non-Euclidean data objects. We target a change in distribution that occurs in a small, unknown subset of dimensions, where these dimensions may be correlated. Our work is motivated by a remote sensing application, where changes occur in small, spatially clustered regions over time. An adaptive block-based change-point detection…

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Debiased Ill-Posed Regression

去偏的病态回归估计

In various statistical settings, the goal is to estimate a function which is restricted by the statistical model only through a conditional moment restriction. Prominent examples include the nonparametric instrumental variable framework for estimating the structural function of the outcome variable, and the proximal causal inference framework for estimating the bridge functions. A common strategy in the literature is to find the minimizer of the projected mean squared error.…

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hmmTMB: hidden Markov models with flexible covariate effects in R

hmmTMB:在 R 中实现灵活协变量效应的隐马尔可夫模型

Hidden Markov models (HMMs) are widely applied in studies where a discrete-valued process of interest is observed indirectly. They have for example been used to model behaviour from human and animal tracking data, disease status from medical data, and financial market volatility from stock prices. The model has two main sets of parameters: transition probabilities, which drive the latent state process, and observation parameters, which characterise the state-dependent…

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Adaptive Estimation of the Transition Density of Controlled Markov Chains

受控马尔可夫链转移密度的自适应估计

Estimating the transition dynamics of controlled Markov chains is crucial in fields such as time series analysis, reinforcement learning, and system exploration. Traditional non-parametric density estimation methods often assume independent samples and require oracle knowledge of smoothness parameters like the Hölder continuity coefficient. These assumptions are unrealistic in controlled Markovian settings, especially when the controls are non-Markovian, since such…

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Nonlinear Meta-Learning Can Guarantee Faster Rates

非线性元学习可保证更快收敛速率

Many recent theoretical works on \emph{meta-learning} aim to achieve guarantees in leveraging similar representational structures from related tasks towards simplifying a target task. The main aim of theoretical guarantees on the subject is to establish the extent to which convergence rates -- in learning a common representation -- \emph{may scale with the number $N$ of tasks} (as well as the number of samples per task). First steps in this setting demonstrate this property…

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Information bounds for inference in stochastic evolution equations observed under noise

噪声观测下随机演化方程推断的信息界

We consider statistics for stochastic evolution equations in Hilbert space with emphasis on stochastic partial differential equations (SPDEs). We observe a solution process under additional measurement errors and want to estimate a real or functional parameter in the drift. Main targets of estimation are the diffusivity, transport or source coefficient in a parabolic SPDE. By bounding the Hellinger distance between observation laws under different parameters we derive lower…

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Quasi-Bayesian Estimation and Inference with Control Functions

使用控制函数的准贝叶斯估计与推断

This paper introduces a quasi-Bayesian method that integrates frequentist nonparametric estimation with Bayesian inference in a two-stage process. Applied to an endogenous discrete choice model, the approach first uses kernel or sieve estimators to estimate the control function nonparametrically, followed by Bayesian methods to estimate the structural parameters. This combination leverages the advantages of both frequentist tractability for nonparametric estimation and…

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A Unified Framework for the Transportability of Population-Level Causal Measures

总体层面因果效应度量可迁移性的统一框架

Generalization methods offer a powerful solution to one of the key drawbacks of randomized controlled trials (RCTs): their limited representativeness. By enabling the transport of treatment effect estimates to target populations subject to distributional shifts, these methods are increasingly recognized as the future of meta-analysis, the current gold standard in evidence-based medicine. Yet most existing approaches focus on the risk difference, overlooking the diverse range…

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Targeted Learning Estimation of Sampling Variance for Improved Inference

以目标学习估计抽样方差以改进推断

For robust statistical inference it is crucial to obtain a good estimator of the variance of the proposed estimator of the statistical estimand. A commonly used estimator of the variance for an asymptotically linear estimator is the sample variance of the estimated influence function. This estimator has been shown to be anti-conservative in limited samples or in the presence of near-positivity violations, leading to elevated Type-I error rates and poor coverage. In this…

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Efficient estimation of the target population average treatment effect from multi-source data

利用多来源数据高效估计目标总体平均处理效应

We consider estimation of the target population average treatment effect (TATE) when outcome information is unavailable. Instead, we observe the outcome in multiple source populations and wish to combine the treatment effects therein to make inference on the TATE. In contrast to existing works that assume transportability on the conditional distribution of potential outcomes or conditional treatment-specific means, we work under a weaker form of effect transportability.…

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Improved Semi-Parametric Bounds for Tail Probability and Expected Loss: Theory and Applications

尾概率与期望损失的改进半参数界:理论与应用

Many management decisions involve accumulated random realizations for which only the first and second moments of their distribution are available. The sharp Chebyshev-type bound for the tail probability and Scarf bound for the expected loss are widely used in this setting. We revisit the tail behavior of such quantities with a focus on independence. Conventional primal-dual approaches from optimization are ineffective in this setting. Instead, we use probabilistic…

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